Yazar "Bakirel, Tulay" seçeneğine göre listele

Listeleniyor 1 - 2 / 2
  • Küçük Resim
    Öğe
    Development and characterization of polymeric-based nanoparticles for sustained release of amoxicillin - an antimicrobial drug
    (Taylor & Francis Ltd, 2018) Guncum, Enes; Isiklan, Nuran; Anlas, Ceren; Unal, Nilgun; Bulut, Elif; Bakirel, Tulay
    In this study, amoxicillin (AMO)-loaded poly(vinyl alcohol)/sodium alginate (PVA/NaAlg) nanoparticles were prepared as a polymer-based controlled release system. The physicochemical properties of the obtained nanoparticles were investigated by XRD, DSC/TGA, particle size analyses and zeta potential measurements. The average particle sizes were in the range from 336.3 +/- 25.66 to 558.3 +/- 31.39 nm with negative zeta potential values from -41.86 +/- 0.55 to-47.3 +/- 2.76 mV. The influences of PVA/NaAlg ratio, span 80 concentration, exposure time to glutaraldehyde (GA) and the drug/polymer ratio on AMO release profiles were evaluated. In vitro drug release studies showed a controlled and pH dependent AMO release with an initial burst effect. XRD patterns and DSC thermograms of AMO-loaded nanoparticles revealed that the drug in the nanoparticles was in amorphous form, which was more stable than the crystalline form. The antibacterial activity of the optimal formulation was also investigated. The minimum inhibitory concentration (MIC) values of this formulation had the comparable antibacterial activity with that of pure AMO. These results indicate that the developed nanoparticles could be a promising candidate drug delivery system for AMO.
  • [ X ]
    Öğe
    Effects of feed intake and water hardness on fluralaner pharmacokinetics in layer chickens
    (Korean Soc Veterinary Science, 2022) Sari, Ataman Bilge; Gunes, Yigit; Anlas, Ceren; Alkan, Fulya Ustun; Guncum, Enes; Ustuner, Oya; Bakirel, Tulay
    Background: Fluralaner is a novel drug belonging to the isoxazoline class that acts on external parasites of domestic animals. It is used systemically via drinking water, especially against red poultry mite in layer chickens. Fluralaner is frequently used in layers infected with D. gallinae. However, no study to date has investigated the effects of feed intake and water hardness. Objectives: This study aimed to investigate the effects of variable water hardness and feed intake on the pharmacokinetic profile of fluralaner. Methods: Layer chickens were divided into four groups (n = 8): fed + purified water (Group 1), feed restricted + purified water (Group 2), feed restricted + hard water (Group 3), and feed restricted + soft water (Group 4). After administering a single dose of the drug with drinking water, the blood samples were collected for 21 days. Fluralaner concentrations in plasma samples were determined by liquid chromatography/tandem mass spectrometry. The maximum plasma concentration ( Cmax), time to reach maximum plasma concentration ( tmax), area under the concentration-time curve values (AUC(0-21d)), half-life ( t(1/2)), and other pharmacokinetic parameters were calculated. Results: Although the highest maximum plasma concentration ( C-max) was determined in Group 1 (fed + purified water), no statistically significant difference was found in the C-max, tmax, t(1/2), MRT0- inf_obs, Vz/ F-obs, and Cl/ F-_ obs parameters between the experimental groups. Conclusions: It was concluded that the feed intake or water hardness did not change the pharmacokinetic profile of fluralaner in layer chickens. Therefore, fluralaner could be used before or after feeding with the varying water hardness in poultry industry.