Development and characterization of polymeric-based nanoparticles for sustained release of amoxicillin - an antimicrobial drug
Yükleniyor...
Tarih
2018
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Taylor & Francis Ltd
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
In this study, amoxicillin (AMO)-loaded poly(vinyl alcohol)/sodium alginate (PVA/NaAlg) nanoparticles were prepared as a polymer-based controlled release system. The physicochemical properties of the obtained nanoparticles were investigated by XRD, DSC/TGA, particle size analyses and zeta potential measurements. The average particle sizes were in the range from 336.3 +/- 25.66 to 558.3 +/- 31.39 nm with negative zeta potential values from -41.86 +/- 0.55 to-47.3 +/- 2.76 mV. The influences of PVA/NaAlg ratio, span 80 concentration, exposure time to glutaraldehyde (GA) and the drug/polymer ratio on AMO release profiles were evaluated. In vitro drug release studies showed a controlled and pH dependent AMO release with an initial burst effect. XRD patterns and DSC thermograms of AMO-loaded nanoparticles revealed that the drug in the nanoparticles was in amorphous form, which was more stable than the crystalline form. The antibacterial activity of the optimal formulation was also investigated. The minimum inhibitory concentration (MIC) values of this formulation had the comparable antibacterial activity with that of pure AMO. These results indicate that the developed nanoparticles could be a promising candidate drug delivery system for AMO.
Açıklama
Bakirel, Tulay/0000-0001-5805-2178
Anahtar Kelimeler
Amoxicillin, polymeric nanocarrier, sustained release, oral drug delivery
Kaynak
Artificial Cells Nanomedicine And Biotechnology
WoS Q DeÄŸeri
Q1
Scopus Q DeÄŸeri
Q1
Cilt
46
Sayı
Künye
Enes Güncüm, Nuran Işıklan, Ceren Anlaş, Nilgün Ünal, Elif Bulut & Tülay Bakırel (2018) Development and characterization of polymeric-based nanoparticles for sustained release of amoxicillin – an antimicrobial drug, Artificial Cells, Nanomedicine, and Biotechnology, 46:sup2, 964-973.
