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Öğe Asperger sendromunda proton manyetik rezonans spektroskopi: Nöropsikolojik testlerle ilişkisi(2009) Öner, Özgür; Özgüven, Halise Devrimci; Öktem, Ferhunde; Yağmurlu, Banu; Baskak, Bora; Ölmez, Şenay; Munir, KerimAmaç: Daha önceki çalışmalarda otizm spektrum bozukluklarında zihin kuramı (ZK) sorunları olduğu gösterilmiştir, ancak bu olgularda ZK performansı ile beyin nörokimyasal bulguları arasındaki ilişki incelenmemiştir. Bu çalışmanın amacı 1H Manyetik Rezonans Spektroskopi (MRS) yöntemiyle dorsolateral prefrontal korteks (DLPFK) ve anterior singulat korteks (ASK) N-Asetil-Aspartat (NAA)/Kolin (Cho), NAA/Kreatin (Cr) ve Cho/Cr değerlerinin ZK performansı ile ilişkisinin incelenmesidir. Yöntem: Onüç sağ elini kullanan, yetişkin erkek Asperger Sendromu (AS) olgusu (yaş 17-37) ve bu olgularla yaş, cinsiyet, el kullanımı ve Weschler Yetişkinler İçin Zeka Ölçeği, Gözden Geçirilmiş Form Toplam Zeka Bölümü bakımlarından benzeştirilmiş 20 sağlıklı kontrol çalışmaya dahil edilmiştir. Bulgular: Bulgular AS olgularının ZK performansının anlamlı şekilde daha düşük olduğunu göstermiştir. DLPFK NAA/Cho düzeyi ZK puanı ile ters korelasyon göstermektedir (r=-.738, p=. 004). Öte yandan ZK performansı ile DLPFK Cho/Cr arasında düz korelasyon bulunmaktadır (r=. 656, p=. 015). ASK MRS değişkenleri ile ZK performansı arasında ise anlamlı bir ilişki bulunmamıştır. Tartışma: Sonuçlar DLPFK Cho düzeyi arttıkça AS olgularında ZK performansının arttığını düşündürmektedir.Öğe Association between serotonin 2A receptor (HTR2A), serotonin transporter (SLC6A4) and brain-derived neurotrophic factor (BDNF) gene polymorphisms and citalopram/sertraline induced sexual dysfunction in MDD patients(NATURE PUBLISHING GROUP, 2020) Oz, Merve Demirbugen; Baskak, Bora; Uckun, Zuhal; Artun, Nazan Yuce; Ozdemir, Hatice; Ozel, Tugba Kizil; Ozguven, Halise DevrimciSexual dysfunction (SD) is a troublesome adverse effect of selective serotonin reuptake inhibitors (SSRIs). A variety of mechanisms might be involved in the occurrence of SD but the exact mechanism is still not clear. Genetic variations among patients treated with SSRIs are strong determinants of intolerance and poor compliance. The present study aimed to determine the relationship between serotonin-2A receptor (HTR2A) gene -1438A/G and 102T/C polymorphisms, serotonin transporter gene (SLC6A4) 5-HTT-linked polymorphic region (5-HTTLPR) insertion/deletion variant and brain-derived neurotrophic factor (BDNF) gene Val66Met polymorphisms and the occurrence of SD adverse effect in major depressive disorder patients treated with citalopram (CIT) or sertraline (SERT). The result from this investigation revealed that the -1438A/G and 102T/C polymorphisms appear to be associated with the SD induced by CIT. It was also demonstrated that patients receiving SERT, carrying T allele of HTR2A or L allele of 5-HTTLPR more likely to experience SD. Most important overall finding of the study is the combined effects of -1438A/G, 102T/C, and 5-HTTLPR polymorphisms. In a logistic regression model, the occurrence of SD increased with the number of risky alleles. As compared with subjects receiving SERT with few risky (<= 2) alleles, those with had 5-6 alleles had an increased SD risk. After all, according to these findings, -1438A/G, 102T/C, and 5-HTTLPR polymorphisms could be considered as promising pharmacogenetic biomarkers in CIT/SERT treatment in major depressive disorder (MDD) patients to avoid the occurrence of SD.Öğe Effect of caffeine on ethanol's sedative and performance-disruptive effects(Elsevier Science Bv, 2007) Özgüven, H. D.; Öner, Özgür; Baskak, Bora; Yağmurlu, Banu; Ölmez, S.; Saka, M. C.; Münir, Kaya…Öğe Influence of CYP2B6 and CYP2C19 polymorphisms on sertraline metabolism in major depression patients(Springer, 2016) Yuce-Artun, Nazan; Baskak, Bora; Ozel-Kizil, Erguvan Tugba; Ozdemir, Hatice; Uckun, Zuhal; Devrimci-Ozguven, Halise; Suzen, Halit SinanBackground Genetic polymorphisms in CYP2B6 and CYP2C19 may cause variability in the metabolism of sertraline, a widely used antidepressant in major depressive disorder treatment. Objective This study investigates the impact of CYP2B6*4 (785A > G), CYP2B6*9 (516G > T), CYP2B6*6 (516G > T + 685G > A) CYP2C19*2 (685G > A), CYP2C19*17 (-3402C > T) polymorphisms on plasma concentrations of sertraline and N-desmethyl sertraline in major depression patients treated with sertraline [n = 50]. Setting Participants were patients who admitted to an adult psychiatry outpatient unit at a university hospital. These were DSM-IV major depression diagnosed patients with a stable sertraline medication regimen [for at least one month]. Methods CYP2B6*4 (rs 2279343; 785A > G), CYP2B6*9 (516G > T; rs 3745274), CYP2B6*6 (516G > T + 685G > A) CYP2C19*2 (rs 4244285; 685G > A), CYP2C19*17 (rs 11188072; -3402C > T), polymorphisms were analyzed by polymerase chain reaction and restriction fragment length polymorphism. Plasma concentrations were measured by high-performance liquid chromatography in patients treated with SERT. Main outcome measure The distribution of CYP2B6*4, *6, *9 and CYP2C19*2, *17 among patient group and the association between genotype and sertraline metabolism. Results Sertraline, N-desmethyl sertraline, N-desmethyl sertraline/sertraline and dose-adjusted plasma concentrations were statistically compared between individuals with wild-type and variant alleles both for CYP2B6 and CYP2C19 enzymes. The mean N-desmethyl sertraline/sertraline value, was significantly lower in all subgroups with *6 and *9 variant alleles (p < 0.05). Sertraline/C values were significantly higher (p < 0.05) and N-desmethyl sertraline/C values were lower in all subgroups with *6 and *9 variant alleles compared to wild-type subgroup. Conclusion CYP2B6*6 and *9 variant alleles had a significant decreasing effect on sertraline metabolism in major depression patients which might result as variations in sertraline therapy.Öğe Proton Magnetic Resonance Spectroscopy in Asperger's Syndrome: Correlations with Neuropsychological Test Scores(Turkiye Sinir Ve Ruh Sagligi Dernegi, 2009) Oner, Ozgur; Ozguven, Halise Devrimci; Oktem, Ferhunde; Yagmurlu, Banu; Baskak, Bora; Olmez, Senay; Munir, KerimObjectives: It has been shown that autistic spectrum patients have impaired theory of mind (ToM) performance; however no study has investigated the relationship between ToM performance and brain neurochemistry in these patients. The present study aimed to investigate the correlations between dorsolateral prefrontal cortex (DLPFC) and anterior cingulate cortex (ACC) N-acetyl-aspartate (NAA)/choline (Cho), NAA/creatine (Cr), and Cho/Cr values based on H-1 magnetic resonance spectroscopy and ToM tests. Method: The study sample included 13 adult, right-handed, Caucasian males with Asperger's syndrome (AS) (age range: 17-37 years) and 20 controls matched by age, gender, handedness, and Wechsler Adult Intelligence Scale, Revised (WAIS-R) full-scale IQ scores. Results: AS cases had significantly lower ToM performance. DLPFC NAA/Cho levels were inversely correlated to ToM scores (r = -0.738, P = 0.004). On the other hand, ToM performance improved as DLPFC Cho/Cr increased (r = 0,655, P = 0.015). ACC MRS variables were not significantly correlated with ToM performance in the AS group. No significant correlation was observed between ACC or DLPFC MRS variables and ToM performance in the control group. Discussion: Because NAA/Cho was inversely correlated with ToM performance and Cho/Cr was correlated with ToM performance, it can be suggested that the Cho level was related to better ToM test performance in the AS group. An increase in the Cho peak was associated with an increase in membrane breakdown or turnover The Cho peak was also thought to reflect cellular density and astrocytosis. It is suggested that membrane turnover and astrocytosis might affect cognitive functioning.Öğe The relationship between the serotonin 2A receptor gene-1438A/G and 102T/C polymorphisms and citalopram/sertraline-induced nausea in major depressed patients(Wiley, 2018) Oz, Merve Demirbugen; Uckun, Zuhal; Yuce-Artun, Nazan; Baskak, Bora; Ozdemir, Hatice; Ozel, Tugba Kizil; Suzen, H. SinanObjective: The aim of the present study was to determine the relationship between the polymorphisms of -1438A/G and 102T/C in the 5-HT2A receptor (HTR2A) gene and nausea/vomiting as a side effect induced by sertraline (SERT) or citalopram (CIT) in patients with major depressive disorder. Methods: A total of 128 patients were enrolled, 63 patients received CIT, whereas 65 patients were treated with SERT. Nausea/vomiting were assessed with the UKU Side-effects Rating Scale at baseline and at the end of the second and fourth weeks. Polymerase chain reaction-restriction fragment length polymorphism technique was employed to determine genetic differences. Results: We have found that, in the patients treated with CIT, there was a nominally significant difference in the genotypic distribution associated with -1438A/G polymorphism between patients with and without nausea (X-2 = 6.15, p = 0.041). Moreover, logistic regression analysis revealed a significant association between nausea/vomiting as a side effect and -1438A/G polymorphism. That is, patients with the G allele were at a higher risk for developing nausea/vomiting (p = 0.044, odds ratio = 2.213). The 102T/C polymorphism in the HTR2A gene had no significant effect on the nausea/vomiting as a side effect among participants treated with either CIT or SERT. Conclusion: The present study suggests the association of the HTR2A gene -1438A/G polymorphism with nausea/vomiting as a side effect related to CIT treatment.
