Proton Magnetic Resonance Spectroscopy in Asperger's Syndrome: Correlations with Neuropsychological Test Scores
Yükleniyor...
Tarih
2009
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Turkiye Sinir Ve Ruh Sagligi Dernegi
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Objectives: It has been shown that autistic spectrum patients have impaired theory of mind (ToM) performance; however no study has investigated the relationship between ToM performance and brain neurochemistry in these patients. The present study aimed to investigate the correlations between dorsolateral prefrontal cortex (DLPFC) and anterior cingulate cortex (ACC) N-acetyl-aspartate (NAA)/choline (Cho), NAA/creatine (Cr), and Cho/Cr values based on H-1 magnetic resonance spectroscopy and ToM tests. Method: The study sample included 13 adult, right-handed, Caucasian males with Asperger's syndrome (AS) (age range: 17-37 years) and 20 controls matched by age, gender, handedness, and Wechsler Adult Intelligence Scale, Revised (WAIS-R) full-scale IQ scores. Results: AS cases had significantly lower ToM performance. DLPFC NAA/Cho levels were inversely correlated to ToM scores (r = -0.738, P = 0.004). On the other hand, ToM performance improved as DLPFC Cho/Cr increased (r = 0,655, P = 0.015). ACC MRS variables were not significantly correlated with ToM performance in the AS group. No significant correlation was observed between ACC or DLPFC MRS variables and ToM performance in the control group. Discussion: Because NAA/Cho was inversely correlated with ToM performance and Cho/Cr was correlated with ToM performance, it can be suggested that the Cho level was related to better ToM test performance in the AS group. An increase in the Cho peak was associated with an increase in membrane breakdown or turnover The Cho peak was also thought to reflect cellular density and astrocytosis. It is suggested that membrane turnover and astrocytosis might affect cognitive functioning.
Açıklama
ozguven, halise/0000-0002-9355-2757; Munir, Kerim M/0000-0002-2404-1806
Anahtar Kelimeler
Asperger's syndrome, magnetic resonance spectroscopy, cingulate gyrus, prefrontal cortex
Kaynak
Turk Psikiyatri Dergisi
WoS Q Değeri
Q4
Scopus Q Değeri
Cilt
20
Sayı
1
Künye
Öner, Ö., Özgüven, H. D., Öktem, F., Yağmurlu, B., Baskak, B., Ölmez, Ş., Munir, K. (2009). Asperger sendromunda proton manyetik rezonans spektroskopi: Nöropsikolojik testlerle ilişkisi. Türk Psikiyatri Dergisi, 20(1), 22 - 27.
