Proton Magnetic Resonance Spectroscopy in Asperger's Syndrome: Correlations with Neuropsychological Test Scores

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dc.contributor.authorOner, Ozgur
dc.contributor.authorOzguven, Halise Devrimci
dc.contributor.authorOktem, Ferhunde
dc.contributor.authorYagmurlu, Banu
dc.contributor.authorBaskak, Bora
dc.contributor.authorOlmez, Senay
dc.contributor.authorMunir, Kerim
dc.date.accessioned2020-06-25T17:48:37Z
dc.date.available2020-06-25T17:48:37Z
dc.date.issued2009
dc.departmentKırıkkale Üniversitesi
dc.descriptionozguven, halise/0000-0002-9355-2757; Munir, Kerim M/0000-0002-2404-1806
dc.description.abstractObjectives: It has been shown that autistic spectrum patients have impaired theory of mind (ToM) performance; however no study has investigated the relationship between ToM performance and brain neurochemistry in these patients. The present study aimed to investigate the correlations between dorsolateral prefrontal cortex (DLPFC) and anterior cingulate cortex (ACC) N-acetyl-aspartate (NAA)/choline (Cho), NAA/creatine (Cr), and Cho/Cr values based on H-1 magnetic resonance spectroscopy and ToM tests. Method: The study sample included 13 adult, right-handed, Caucasian males with Asperger's syndrome (AS) (age range: 17-37 years) and 20 controls matched by age, gender, handedness, and Wechsler Adult Intelligence Scale, Revised (WAIS-R) full-scale IQ scores. Results: AS cases had significantly lower ToM performance. DLPFC NAA/Cho levels were inversely correlated to ToM scores (r = -0.738, P = 0.004). On the other hand, ToM performance improved as DLPFC Cho/Cr increased (r = 0,655, P = 0.015). ACC MRS variables were not significantly correlated with ToM performance in the AS group. No significant correlation was observed between ACC or DLPFC MRS variables and ToM performance in the control group. Discussion: Because NAA/Cho was inversely correlated with ToM performance and Cho/Cr was correlated with ToM performance, it can be suggested that the Cho level was related to better ToM test performance in the AS group. An increase in the Cho peak was associated with an increase in membrane breakdown or turnover The Cho peak was also thought to reflect cellular density and astrocytosis. It is suggested that membrane turnover and astrocytosis might affect cognitive functioning.en_US
dc.description.sponsorshipFIC NIH HHSUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH Fogarty International Center (FIC) [D43 TW005807]en_US
dc.identifier.citationÖner, Ö., Özgüven, H. D., Öktem, F., Yağmurlu, B., Baskak, B., Ölmez, Ş., Munir, K. (2009). Asperger sendromunda proton manyetik rezonans spektroskopi: Nöropsikolojik testlerle ilişkisi. Türk Psikiyatri Dergisi, 20(1), 22 - 27.en_US
dc.identifier.endpage27en_US
dc.identifier.issn1300-2163
dc.identifier.issue1en_US
dc.identifier.pmid19306123
dc.identifier.startpage22en_US
dc.identifier.trdizinidtrdizinikyoktur
dc.identifier.urihttps://hdl.handle.net/20.500.12587/4509
dc.identifier.volume20en_US
dc.identifier.wosWOS:000264595300003
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakTR-Dizin
dc.indekslendigikaynakPubMed
dc.language.isotr
dc.publisherTurkiye Sinir Ve Ruh Sagligi Dernegien_US
dc.relation.ispartofTurk Psikiyatri Dergisi
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAsperger's syndromeen_US
dc.subjectmagnetic resonance spectroscopyen_US
dc.subjectcingulate gyrusen_US
dc.subjectprefrontal cortexen_US
dc.titleProton Magnetic Resonance Spectroscopy in Asperger's Syndrome: Correlations with Neuropsychological Test Scoresen_US
dc.typeArticle

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