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Öğe Acute cholecystitis complicated by pylephlebitis(Aves, 2014) Sapmaz, Ferdane; Kalkan, Ismail Hakki; Guliter, Sefa; Bilgili, Yasemin Karadeniz…Öğe ADC evaluation of the corticospinal tract in multiple sclerosis(Springer Heidelberg, 2015) Inal, Mikail; Unal, Birsen; Kala, Ibrahim; Turkel, Yakup; Bilgili, Yasemin KaradenizApparent diffusion coefficient (ADC) values derived from diffusion-weighted MR imaging (DWI) provide important information about tissues. The goal of this study was to evaluate the ADC values in the corticospinal tract regions in multiple sclerosis (MS). The ADC values of 42 patients with multiple sclerosis and 46 healthy people were measured. The ADC values in the corticospinal tract at the capsula interna posterior crus from six points and mesencephalon from three points bilaterally in MS patients were compared with those of controls. An ANOVA post hoc test was used to analyse the differences in mean ADC values between the MS and control groups. The mean ADC values of the right (p = 0.008) and left internal capsules (p = 0.000) and right (p = 0.002) and left mesencephalons (p = 0.044) in MS patients were significantly lower than in the control group. There was no significant difference between the right and left side ADC values in MS (p = 0.313 vs. p = 0.223) and control groups (p = 0.756 vs. p = 0.105), respectively. The mean ADC values of the corticospinal tract in MS patients were significantly lower than in the control group. This decreased diffusion may be the result of cellular infiltration due to inflammation, cytotoxic oedema, demyelination or remyelination processes.Öğe ADC evaluations of the hippocampus and amygdala in multiple sclerosis(Asean Neurological Assoc, 2014) Inal, Mikail; Daphan, Birsen Unal; Bilgili, Yasemin Karadeniz; Turkel, Yakup; Kala, IbrahimBackground & Objective: Diffusion-weighted MR imaging and apparent diffusion coefficient (ADC) values provide significant structural information about tissues in multiple sclerosis (MS). The goal of this study was to evaluate the ADC values in the hippocampus and amygdala in MS. Methods: Thirty-eight patients with MS and 41 healthy individuals were included in the study. ADC values were measured bilaterally from three different points in the hippocampus and amygdala in MS patients and were compared with those of the controls. An analysis of varianceposthoc test was used to analyse the differences among mean ADC values between MS and control groups. Results: The mean ADC values of both sides of the hippocampus and the left amygdala in MS patients were lower than the control group. The mean ADC values of the right amygdala in MS patients were lower than the control group, but the difference was not statistically significant. Conclusion: We observed restricted diffusion in the hippocampus and amygdala in MS patients contrary to information in the literature.Öğe ADC evaluations of the hippocampus and amygdale in multiple sclerosis(ASEAN Neurological Association, 2014) Inal, Mikail; Daphan, Birsen Unal; Bilgili, Yasemin Karadeniz; Turkel, Yakup; Kala, IbrahimBackground & Objective:Diffusion-weighted MR imaging and apparent diffusion coefficient (ADC) values provide significant structural information about tissues in multiple sclerosis (MS).The goal of this study was to evaluate the ADC values in the hippocampus and amygdala in MS. Methods:Thirtyeightpatients with MS and 41 healthy individualswere included in the study. ADC values were measured bilaterallyfrom three different pointsin the hippocampus and amygdala in MS patients and were compared with those of the controls. An analysis of varianceposthoc test was used to analyse the differences among mean ADC values between MS and control groups.Results:The mean ADC values of both sides of thehippocampus and the left amygdala in MS patients were lower than the control group. The mean ADC values of the right amygdala in MS patients were lower than the control group, but the difference was not statistically significant.; Conclusion:We observed restricted diffusion in the hippocampus and amygdala in MS patients contrary to information in the literature. © 2014, ASEAN Neurological Association. All rights reserved.Öğe Better Visualization of Vermiform Appendix With Tissue Harmonic Imaging Compared to Conventional Sonography(Kowsar Publ, 2014) Inal, Mikail; Unal, Birsen; Bilgili, Yasemin KaradenizBackground: Surgery of appendicitis carries 7-11% negative appendectomy rates. Sonographically visualized normal appendix precludes unnecessary computed tomography (CT) examination and may reduce negative appendectomy rates. Tissue harmonic imaging (THI) has been reported to improve the overall image quality. Objective: We aimed to assess whether THI is more successful than conventional ultrasonography (US) in detecting normal and pathologic appendices. Patients and Methods: The study was performed on 185 patients who applied for routine US examinations in whom clinical findings of appendicitis were detected in 25. We searched for the appendix; applying both THI and conventional US to each patient, one before and the other after the routine US examinations. Patients were divided into two groups; one was evaluated first with conventional US and the other first with THI. When the appendix was found, localization, diameter and time spent for visualization were recorded. Twelve patients were operated; all of whom had appendicitis pathologically. Two methods were compared for: 1. Success rates in all patients; female, male and child groups separately; 2. Visualization of pathologic and normal appendices; 3. Time for visualization of appendix; 4. Comparison of success rates in the adult and child population. The relationship between the rate of visualization and body mass index was evaluated. Results: The appendix was visualized better by THI in all patients, and in the female and male groups (P < 0.001). In children, both methods were more successful compared to adults (P < 0.001, compared to male group, P < 0.001, compared to female group), with no difference between the methods (P = 0.22). When only the normal appendices were concerned, there was significant difference between both methods (P < 0.000). Both methods detected pathologic appendices better than normal ones, with a higher ratio for THI (P = 0.022 for the THI group, and chi(2) = 7.22, P = 0.07 for the conventional US group). THI visualized the appendix faster. Both methods were more successful in lean patients (P = 0.004 for THI, P = 0.001 for conventional US imaging). Conclusions: THI visualizes appendix better than conventional US. It is a simple and time saving method that may eliminate further diagnostic imaging, and it may decrease negative appendectomy rates and related complications.Öğe Cerebral hemodynamics in ocular hypertension(Springer, 2005) Akarsu, Cengiz; Bilgili, Yasemin Karadeniz; Ünal, Birsen; Taner, Pelin; Ergin, Ahmet; Kara, Simay AltanPurpose: To evaluate the cerebral blood flow velocity in patients with ocular hypertension. Material and methods: Twenty-four ocular hypertensive patients and 24 age- and sex-matched healthy volunteers were recruited in a prospective comparative study. All subjects had normal findings on full-threshold visual field tests and clinically normal optic nerves. All patients with ocular hypertension had an intraocular pressure (IOP) of > 21 mmHg on three separate occasions without treatment. Systolic and diastolic blood pressure by cuff, heart rate by palpation, IOP by Goldmann applanation tonometry, central corneal thickness by ultrasound pachymetry, blood flow velocities, and pulsatility index of the ipsilateral middle cerebral artery by transcranial color Doppler were measured. Results: Systolic and diastolic blood pressures ( P= 0.40 and P= 0.45, respectively), heart rate ( P= 0.30), and central corneal thickness ( P= 0.23) were similar in each group. Peak and end-diastolic blood flow velocities in the middle cerebral artery did not differ between ocular hypertensives and controls ( P= 0.37 and P= 0.87, respectively). In addition, pulsatility index did not significantly differ between ocular hypertensives and controls ( P= 0.61). Conclusions: The results of this study suggest that ocular hypertension is not associated with reduction in blood flow velocity and elevation of resistance in the middle cerebral artery.Öğe The Diagnostic Value of sTWEAK in Acute Ischemic Stroke(GALENOS YAYINCILIK, 2020) Comertpay, Ertan; Vural, Sevilay; Eroglu, Oguz; Badem, Nermin Dindar; Bilgili, Yasemin Karadeniz; Coskun, FigenBackground: Considering the critical role of early diagnosis and management of acute ischemic stroke, biomarkers that can reliable assist in the diagnosis are still needed. These biomarkers should rapidly analyze, have high specificity for brain damage, and be available in the emergency settings for early diagnosis and exclusion of other conditions that mimic acute ischemic stroke. Soluble tumor necrosis factor-like weak inducer of apoptosis, a protein involved in the regulation of several biological functions, could be a potential acute ischemic stroke biomarker. Aims: To investigate the diagnostic value of soluble tumor necrosis factor-like weak inducer of apoptosis in patients with acute ischemic stroke and examine the relationship between ischemic area volume determined at diffusion-weighted magnetic resonance imaging and soluble tumor necrosis factor-like weak inducer of apoptosis. Study Design: A prospective, case-control study. Methods: This case-control prospective study included 36 patients with acute ischemic stroke and 36 healthy volunteers. Information on age, sex, presence of chronic disease, neurological examination findings, times of presentation to the emergency department after acute ischemic stroke, soluble tumor necrosis factor-like weak inducer of apoptosis levels, ischemic area volumes at diffusion-weighted magnetic resonance imaging, and 6-month mortality rates after stroke were recorded. The results were analyzed on SPSS 22.0 software (SPSS Inc., Chicago, IL, USA), and p<0.05 was considered statistically significant. Results: A soluble tumor necrosis factor-like weak inducer apoptosis cut-off value of 995.5 pg/mL exhibited a sensitivity of 80.5% and a positive predictive value of 82.5% with an area under the curve of 0.84 (95% confidence interval: 0.74-0.94; p<0.001). The mean soluble tumor necrosis factor-like weak inducer of apoptosis level - in the acute ischemic stroke group (1968.08=1441.99 mu g/L) were significantly higher than those in the control group (704.81 +/- 291.72 14,1) (p<0.001). No correlation was observed between soluble tumor necrosis factor-like weak inducer of apoptosis levels and ischemic area volume measured at diffusion-weighted magnetic resonance imaging (r=-0.008; p=0.07). The mean ischemic area volume was 505.68 +/- 381.10 and 60.96=80.89 mm(3) in the nonsurviving and surviving patients, respectively (p =.002). Conclusion: Soluble tumor necrosis factor-like weak inducer of apoptosis can be used in the diagnosis of acute ischemic stroke. However, it is inconclusive in estimating ischemic area volume and early mortality following acute ischemic stroke. Ischemic area volume measured at diffusion-weighted magnetic resonance imaging is a marker of poor prognosis and can be used in predicting early mortality.Öğe Ischemic colitis in a young woman following colonoscopy(Springer Wien, 2014) Sapmaz, Ferdane; Kalkan, Ismail Hakki; Gueliter, Sefa; Bilgili, Yasemin Karadeniz…Öğe A juxtapapillary windsock diverticulum connected with the third portion of the duodenum via a natural orifice(Aves, 2014) Sapmaz, Ferdane; Kalkan, Ismail Hakki; Bilgili, Yasemin Karadeniz; Guliter, Sefa…Öğe The diagnostic value of neurogranin in patients with carbon monoxide poisoning: Can it show early neurological damage?(W B Saunders Co-Elsevier Inc, 2021) Yesilyurt, Omer; Comertpay, Ertan; Vural, Sevilay; Eroglu, Oguz; Badem, Nermin Dindar; Cankaya, Imran; Bilgili, Yasemin KaradenizBackground and aim: Carbon monoxide poisoning is a toxicological emergency that causes neurological complications. High serum neurogranin can be detected in acute or chronic conditions where brain tissue is damaged. This study aimed to investigate the diagnostic value of serum neurogranin level and its role in demonstrating neurological damage in patients admitted to the emergency department with carbon monoxide poisoning. Materials and methods: The study was conducted prospectively on patients with carbon monoxide poisoning (patient group) and healthy volunteers (control group). Demographic characteristics and scrum neurogranin level of all participants and symptoms at admission, neurological examination findings, laboratory results, and Diffusion-Weighted Magnetic Resonance Imaging results of the patient group were recorded. We used an independent sample t-test to compare neurogranin levels and bivariate correlation analysis to compare the relationship between serum neurogranin levels and data belonging to the patient group. Results: Sixty eight participants (patient group, n- 36; control group, n- 32) were included in the study. Serum neurogranin level was significantly higher in patients with carbon monoxide poisoning (0.31 +/- 0.16 ng/ml) compared to control group (0.22 +/- 0.10 ng/ml) (p = 0.015). The mean Glasgow Coma Scale of the patients with carbon monoxide poisoning was 14.59 +/- 0.23, and of Diffusion Weighted Magnetic Resonance Imaging results were completely normal in 94.4% (n = 34). There was no correlation between serum neurogranin level and Diffusion Weighted Magnetic Resonance Imaging results (r = -0.011; p = 0.953). Conclusion: Serum neurogranin level may be a new diagnostic biomarker in patients admitted to the emergency department with carbon monoxide poisoning. The high serum neurogranin levels detected in patients with normal diffusion-weighted imaging after carbon monoxide poisoning suggest that there is neurological damage in these patients, even if imaging methods cannot detect it. (C) 2021 Elsevier Inc. All rights reserved.Öğe Unilateral isolated alar ligament rupture in an adult female patient(Kare Publ, 2021) Keskil, Semih; Yuksel, Ulas; Bilgili, Yasemin Karadeniz; Babacan, AvniOnly seven cases of isolated unilateral rupture of the alar ligament had been previously reported. The authors report the first adult female case of this rare injury. The patient in their case, a 36-year-old female presented after a trauma due to falling, and at that moment, she had fainted due to a sudden pain between the neck and head. The radiological examinations [magnetic resonance imaging (MRI) and X-rays] had been interpreted as normal. She had a positive Alar ligament test at the right side, and a thin section craniovertebral junction computed tomography was obtained which revealed an asymmetrically left-sided odontoid process and a new MRI revealed a right-sided alar ligament rupture. Th us she underwent a bilateral greater occipital nerve block together with pulse radiofrequency and trigger point injection at splenius capitis, levator scapula, and trapezius followed by the application of a halo orthosis to be worn for 3 months. The patient was found to be pain-free in the follow-up examinations. With pure unilateral alar ligament rupture, the atlantooccipital joint is not disrupted and the craniovertebral junction is not destabilized. To date, only eight cases of isolated unilateral alar ligament rupture have been reported one of which was a 25 years old male; all of whom presented with marked neck pain and treated by external immobilization for 4 weeks to 4 months and our case is the first adult female patient.
