Yazar "Birben, Esra" seçeneğine göre listele

Listeleniyor 1 - 2 / 2
  • Küçük Resim
    Öğe
    Pepsin levels and oxidative stress markers in exhaled breath condensate of patients with gastroesophageal reflux disease
    (W B Saunders Co-Elsevier Inc, 2013) Soyer, Tutku; Soyer, Ozge Uysal; Birben, Esra; Kisa, Ucler; Kalayci, Omer; Cakmak, Murat
    Aim: To evaluate the pepsin and oxidative stress markers in exhaled breath condensate (EBC) in patients with gastroesophageal reflux disease (GERD). Patients and Method: Patients with a presumptive diagnosis of GERD with recurrent respiratory and gastrointestinal problems aged between 2 and 14 years were included in the study. All patients underwent pH monitoring. Patients with a reflux index (RI) >= 4 were assessed as the reflux group, and those with an RO <4 were assessed as the non-reflux group. Pepsin levels and oxidative stress markers [NO metabolites (NOX) and total sulphydrile (TSH) levels] were measured in the EBC. Results: There were 24 patients in the reflux group [RI 17.6 (6.6-46.4)] [median, interquartile range] and 23 in the non-reflux group [RI 0.8 (0.5-1.9) (p < 0.001). Pepsin levels in the EBC were below the level of detection. The median levels of NOx in the EBC of children with reflux [13.7 mu mol/L (7.3-24.5)] were lower in than non-reflux group [21.0 mu mol/L (14.0-25.2)] (p = 0.034). There was a negative correlation between reflux index and NOX levels in EBC (rs: -0.331, p = 0.023). In contrast, there was no difference in TSH levels between the reflux and non-reflux groups [37.4 mu mol/L (30.2-44.6) vs 40.1 mu mol/L (37.4-44.9), respectively, (p > 0.05)]. Conclusion: Decreased levels of NOX in patients with GER disease suggest increased oxidative stress in airways of these patients. (C) 2013 Elsevier Inc. All rights reserved.
  • Küçük Resim
    Öğe
    The role of CD14 gene promoter polymorphism in tuberculosis susceptibility
    (Elsevier Taiwan, 2013) Ayaslioglu, Ergin; Kalpaklioglu, Fusun; Kavut, Ayse Baccioglu; Erturk, Arzu; Capan, Nermin; Birben, Esra
    Background: CD14 is expressed principally by cells of monocyte/macrophage lineage and plays a pivotal role in the innate immunity to intracellular infections. Recent research findings have revealed an association between the CD14 gene promoter polymorphism and several major infectious diseases. Objective: The aim of the present study was to investigate the association between the CD14-159C/T polymorphism and tuberculosis in a Turkish population. Methods: For this purpose, 88 consecutive patients with tuberculosis (63 pulmonary, 25 extra-pulmonary) and 116 control subjects were enrolled into a prospective study. We determined CD14-159 genotypes by polymerase chain reaction - restriction fragment length polymorphism analysis and also measured serum concentrations of soluble CD14 (sCD14) by using a quantitative sandwich enzyme immunoassay technique. Results: There was no significant difference in terms of genotype distribution between patients with tuberculosis (CC 18.2%, CT 48.9%, TT 33.0%) and controls (CC 12.9%, CT 50.9%, TT 36.2%) or between patients with pulmonary and extrapulmonary tuberculosis. Serum levels of sCD14 were significantly increased in patients with active tuberculosis compared to those with inactive tuberculosis and healthy controls (p < 0.001). However, levels of sCD14 were not associated with any genotypes of CD14-159. Conclusion: The genotyping findings of the present study do not support a role for the CD14-159C/T polymorphism in the development of tuberculosis, at least in the geographical region of central Anatolia. Significantly elevated serum sCD14 levels in patients with active disease reflect the importance of the mononuclear phagocytic system activation in tuberculosis. Copyright (C) 2012, Taiwan Society of Microbiology. Published by Elsevier Taiwan LLC. All rights reserved.