Pepsin levels and oxidative stress markers in exhaled breath condensate of patients with gastroesophageal reflux disease
Yükleniyor...
Tarih
2013
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
W B Saunders Co-Elsevier Inc
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Aim: To evaluate the pepsin and oxidative stress markers in exhaled breath condensate (EBC) in patients with gastroesophageal reflux disease (GERD). Patients and Method: Patients with a presumptive diagnosis of GERD with recurrent respiratory and gastrointestinal problems aged between 2 and 14 years were included in the study. All patients underwent pH monitoring. Patients with a reflux index (RI) >= 4 were assessed as the reflux group, and those with an RO <4 were assessed as the non-reflux group. Pepsin levels and oxidative stress markers [NO metabolites (NOX) and total sulphydrile (TSH) levels] were measured in the EBC. Results: There were 24 patients in the reflux group [RI 17.6 (6.6-46.4)] [median, interquartile range] and 23 in the non-reflux group [RI 0.8 (0.5-1.9) (p < 0.001). Pepsin levels in the EBC were below the level of detection. The median levels of NOx in the EBC of children with reflux [13.7 mu mol/L (7.3-24.5)] were lower in than non-reflux group [21.0 mu mol/L (14.0-25.2)] (p = 0.034). There was a negative correlation between reflux index and NOX levels in EBC (rs: -0.331, p = 0.023). In contrast, there was no difference in TSH levels between the reflux and non-reflux groups [37.4 mu mol/L (30.2-44.6) vs 40.1 mu mol/L (37.4-44.9), respectively, (p > 0.05)]. Conclusion: Decreased levels of NOX in patients with GER disease suggest increased oxidative stress in airways of these patients. (C) 2013 Elsevier Inc. All rights reserved.
Açıklama
KISA, Ucler/0000-0002-8131-6810; Soyer, Tutku/0000-0003-1505-6042
Anahtar Kelimeler
Children, Exhaled breath condensate, Gastroesophageal reflux disease, Oxidative stress, Pepsin
Kaynak
Journal Of Pediatric Surgery
WoS Q Değeri
Q3
Scopus Q Değeri
Q1
Cilt
48
Sayı
11
Künye
closedAccess
