Pepsin levels and oxidative stress markers in exhaled breath condensate of patients with gastroesophageal reflux disease

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dc.contributor.authorSoyer, Tutku
dc.contributor.authorSoyer, Ozge Uysal
dc.contributor.authorBirben, Esra
dc.contributor.authorKisa, Ucler
dc.contributor.authorKalayci, Omer
dc.contributor.authorCakmak, Murat
dc.date.accessioned2020-06-25T18:06:59Z
dc.date.available2020-06-25T18:06:59Z
dc.date.issued2013
dc.departmentKırıkkale Üniversitesi
dc.descriptionKISA, Ucler/0000-0002-8131-6810; Soyer, Tutku/0000-0003-1505-6042
dc.description.abstractAim: To evaluate the pepsin and oxidative stress markers in exhaled breath condensate (EBC) in patients with gastroesophageal reflux disease (GERD). Patients and Method: Patients with a presumptive diagnosis of GERD with recurrent respiratory and gastrointestinal problems aged between 2 and 14 years were included in the study. All patients underwent pH monitoring. Patients with a reflux index (RI) >= 4 were assessed as the reflux group, and those with an RO <4 were assessed as the non-reflux group. Pepsin levels and oxidative stress markers [NO metabolites (NOX) and total sulphydrile (TSH) levels] were measured in the EBC. Results: There were 24 patients in the reflux group [RI 17.6 (6.6-46.4)] [median, interquartile range] and 23 in the non-reflux group [RI 0.8 (0.5-1.9) (p < 0.001). Pepsin levels in the EBC were below the level of detection. The median levels of NOx in the EBC of children with reflux [13.7 mu mol/L (7.3-24.5)] were lower in than non-reflux group [21.0 mu mol/L (14.0-25.2)] (p = 0.034). There was a negative correlation between reflux index and NOX levels in EBC (rs: -0.331, p = 0.023). In contrast, there was no difference in TSH levels between the reflux and non-reflux groups [37.4 mu mol/L (30.2-44.6) vs 40.1 mu mol/L (37.4-44.9), respectively, (p > 0.05)]. Conclusion: Decreased levels of NOX in patients with GER disease suggest increased oxidative stress in airways of these patients. (C) 2013 Elsevier Inc. All rights reserved.en_US
dc.description.sponsorshipKirikkale University Scientific Research UnitKirikkale Universityen_US
dc.description.sponsorshipThis study was supported by Kirikkale University Scientific Research Unit and presented in National Congress of Turkish Pediatric Surgeons on 30 September-3 October 2009, in Malatya, Turkey.en_US
dc.identifier.citationclosedAccessen_US
dc.identifier.doi10.1016/j.jpedsurg.2013.02.100
dc.identifier.endpage2250en_US
dc.identifier.issn0022-3468
dc.identifier.issn1531-5037
dc.identifier.issue11en_US
dc.identifier.pmid24210194
dc.identifier.scopus2-s2.0-84887604148
dc.identifier.scopusqualityQ1
dc.identifier.startpage2247en_US
dc.identifier.urihttps://doi.org/10.1016/j.jpedsurg.2013.02.100
dc.identifier.urihttps://hdl.handle.net/20.500.12587/5433
dc.identifier.volume48en_US
dc.identifier.wosWOS:000327140800012
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherW B Saunders Co-Elsevier Incen_US
dc.relation.ispartofJournal Of Pediatric Surgery
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectChildrenen_US
dc.subjectExhaled breath condensateen_US
dc.subjectGastroesophageal reflux diseaseen_US
dc.subjectOxidative stressen_US
dc.subjectPepsinen_US
dc.titlePepsin levels and oxidative stress markers in exhaled breath condensate of patients with gastroesophageal reflux diseaseen_US
dc.typeArticle

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