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    Hormone replacement therapy and prolactin levels in postmenopausal women
    (1999) Sagsoz N.; Bayram M.; Kamaci M.; Caglayan O.
    Objective: Our purpose was to investigate the effect of hormonal replacement therapy on serum prolactin (PRL) levels in postmenopausal women. Study Design: Hormone replacement therapy (HRT) was initiated to 30 postmenopausal patients. We determined the basal prolactin levels before treatment, and again at the first and third months. We used paired-t and student-t test for statistical analysis. Results: The basal PRL level of menopausal women was 9.6 ± 4.6 ng/ml, while it was 10.5 ± 4.1 ng/ml in premenopausal women (p>0,05). After initiation of HRT, the PRL levels were 9.9 ± 3.3 ng/ml and 10.1 ± 3.9 ng/ml at the first and third months, respectively. These values were not different from basal PRL levels. Conclusion: Serum prolactin determination may be used for the diagnosis of secondary amenorrhea of menopause if clinically indicated. Howover checking the serum prolactin level after the initiation of HRT has no clinical implications.
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    Monitoring the metabolic response to major surgery in neonates.
    (2000) Caglayan F.; Caglayan O.; Gunel E.; Sahin T.K.
    BACKGROUND: Visceral proteins and acute phase reactants have commonly been used as indicators of nutritional status, and metabolic response of surgical trauma. AIM: This study was undertaken to determine how some plasma proteins, alone or together reflect metabolic response in neonates recovering from major surgery. METHODS: Serum albumin, pre-albumin (PA), C-reactive protein (CRP), and alpha1-acid glycoprotein (AGP) levels were measured, and the prognostic inflammatory and nutritional index (PINI) was calculated for preoperative day 1 (-1) and postoperative (PO) days 1 (+1) and 7 (+7). RESULTS: PA, CRP, AGP and PINI were significantly different on day +1 from day -1. While AGP and PINI were still significantly higher than that of day -1, PA and CRP returned to the preoperative levels on day +7. CONCLUSION: PA, CRP and AGP measurements are superior to PINI for assessing postoperative metabolic changes in term neonates following uncomplicated major surgery on early and late phase. But this comparison must be performed in the management of more complex cases to determine which one is better to indicate morbidity and mortality.
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    Plasma antioxidant enzyme levels in smoker and non-smoker pregnant women and their correlation with uterine arterial doppler parameters
    (Scientific Publishers of India, 2018) Celikel O.O.; Noyan V.; Caglayan O.
    Introduction: Cigarettes contain many free radicals and cause oxidative stress in the body. Its contents decrease blood fluidity and blood stream by affecting the vascular endothelium; further, they directly or indirectly impair placental perfusion. Material and method: Catalase (CAT), malondialdehyde (MDA) and total sulfhydryl (SH) levels were analysed in venous blood specimens obtained from 49 smoker and 35 non-smoker pregnant women (age, 18-35 y) who were in the second trimester. Uterine arterial Doppler ultrasonography was performed to evaluate uterine perfusion. Pulsatile index (PI), resistance index (RI) and systole/diastole ratio (S/D) was measured. The smoker group was further subdivided into two groups: 1. those who smoked for <5 y and 2. Those who smoked for >5 y. Obtained data were analysed using the SPSS 11 statistical programme. Results: No significant differences were observed between the smoker and non-smoker groups in terms of demographic parameters and right–left uterine arterial Doppler parameters. The mean S/D ratio was significantly higher in the smoker group (P=0.01). The mean PI, mean RI and plasma MDA, CAT and total SH levels were similar in both groups. Although not statistically significant, the mean PI, RI and S/D ratio values of the smoker pregnant women who smoked for ? 5 y was found to be higher than of those who smoked for <5 y. Conclusion: There is no correlation between plasma antioxidant enzyme levels and uterine artery Doppler parameters; however, the duration of smoking may affect uterine perfusion. © 2018, Scientific Publishers of India. All rights reserved.
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    Serum orexin-a level and the severity of coronary artery disease: Original article
    (Cardiology Academic Press, 2014) Simsek V.; Dogru M.T.; Boyunaga H.; Caglayan O.; Yildirim N.; Tulmaç M.; Ebinc H.
    In this study, we aimed to investigate the correlations of serum Orexin-A level (SOAL) and the severity of coronary artery disease (CAD). A total of 80 participants (mean age: 55.7±12.7 years) were enrolled into the study. SOAL, electrocardiography and transthoracic echocardiography and 24 Hour Holter monitoring (24HHM) and coronary angiography were performed in all participants. Autonomic functions were assessed using the data of Heart Rate Variability measurements. Patients were categorized into three groups according to their Gensini scores as: Group 1: The patients with normal coronary angiogram, Group 2: The patients with mild CAD (Gensini <20) and Group 3: The patients with severe CAD (Gensini ?20). A total of 28 patients were Group 1 (mean age 51.8±12.0 years), 25 patients were Group 2 (mean age 57.7±11.6 years) and 27 patients were Group 3 (mean age 57.6±13.6 years). There were statistically significant differences in SOAL (p=0.004) among the groups. We found that SOAL had statistically significant associations with Gensini score and LF/HF (Sympathetic activity) values. (F= 15.299; p=0.004 and F= 15.470; p=0.004, respectively). Serum Orexin-A levels are positively correlated with severity of CAD and sympathetic activity.