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    Are Lipoprotein Levels and Ratios Able to Predict Mortality due to Sepsis?
    (Coll Physicians & Surgeons Pakistan, 2020) Karahan, Irfan; Cifci, Aydin
    Objective: To compare lipoprotein levels, and non-HDL to high-density lipoprotein (HDL) ratios of survivors and nonsurvivors of sepsis, and to determine the predictivity levels of specified parameters in mortality. Study Design: Descriptive study. Place and Duration of Study: Department of Internal Medicine, Kirikkale University, School of Medicine, Training and Research Hospital, Kirikkale, Turkey, from December 2017 to December 2018. Methodology: The study subjects included 37 non-survivors and 32 survivors of sepsis with similar ages, comorbidities, and disease activities. The total lipoprotein levels, and non-HDL to HDL ratios of the participants were compared retrospectively. Results: HDL and non-HDL to HDL ratios were found to be different between the two groups. The cut-off levels of these values were determined as 32 and 3.4, respectively. The cut-off levels found in the study suggest that the low HDL levels and high non-HDL to HDL ratios significantly increase the mortality risk for patients (OR=1.8 and 3.45, respectively). Conclusion: Non-HDL to HDL ratio may be used as a useful tool for predicting sepsis mortality. These values may also be included as a part of scoring systems. Further investigations are needed to clarify the role of lipoproteins in sepsis.
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    Choroidal thickness in obese women
    (Biomed Central Ltd, 2016) Yumusak, Erhan; Ornek, Kemal; Durmaz, Senay Arikan; Cifci, Aydin; Guler, Hatice Ayhan; Bacanli, Zehra
    Background: Excessive weight is a well-known risk factor for microvascular diseases. Changes in thickness in a vascular tissue, such as the choroid, can be useful to evaluate the effect of obesity on the microvascular system. The aim of this study was to evaluate the choroidal thickness (CT) changes in obese women, using optical coherence tomography (OCT). Methods: The prospective clinical study included examination of the right eyes of 72 patients. The right eyes of 68 patients were examined and served as the controls. A complete ophthalmological examination and OCT imaging were performed for each group studied. The CT in each eye was measured using OCT. Results: The obese group consisted of 72 female patients with a mean age of 37.27 +/- 1.18 years. The control group included 68 female subjects with a mean age of 37.85 +/- 7.98 years (p > 0.05). There was no statistical significant difference for the foveal retinal thickness measurements between the two groups (p > 0.5). Our study revealed significant choroidal tissue thickening subfoveally and at areas 500 mu m temporal, 500 mu m nasal, and 1500 mu m nasal to the fovea in the obese group (all p < 0.05). There was a positive correlation between body mass index (BMI) and CT changes. Conclusions: CT may increase in obese women and a positive correlation was found between BMI and CT. The trial protocol was approved by the Local Ethical Committee of the Kirikkale University, date of registration: April 27, 2015 (registration number: 10/11).
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    The comparison of pandemic H1N1 IgG levels between H1N1 influenza-vaccinated healthcare workers and unvaccinated healthcare workers
    (Tubitak Scientific & Technical Research Council Turkey, 2014) Cifci, Aydin; Erol, Ozlem; Cesur, Salih; Aksoy, Nurkan; Kisa, Ucler
    Background/aim: To compare pandemic H1N1 (pH1N1) IgG antibody levels between healthcare workers who were vaccinated with the pH1N1 influenza vaccine and the unvaccinated healthcare workers who were selected as the control group. Materials and methods: A total of 68 healthcare workers were included in this study. Of those, 53 were adults vaccinated with the H1N1 influenza vaccine and 15 were unvaccinated. Serum samples were parsed and stored at -40 degrees C until they were examined. Results: Of the total 53 vaccinated healthcare workers, 16 (30.1%) were positive for IgG antibodies (titer > 11), 17 (32.0%) were negative for IgG antibodies (titer < 9), and 20 (37.7%) were borderline (titer: 9-11). Of the 15 unvaccinated healthcare workers, 1 (6.6%) was positive for IgG antibodies, 11 (73.3%) were negative for IgG antibodies, and the remaining 3 (20.0%) had borderline values (P = 0.014, P < 0.05). In both groups, there was no statistically significant difference between IgG-negative, IgG-positive, and borderline subjects in terms of age or sex. Conclusion: The IgG antibody level was higher in the vaccinated healthcare workers than among the unvaccinated healthcare workers.
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    Effects of D3K2 With Periodontal Therapy in Diabetes Mellitus and Stage I-II Periodontitis Patients
    (Wiley, 2024) Aydogan, Tolga; Karsiyaka Hendek, Meltem; Unsal, Berrin; Cifci, Aydin; Varol, Hakan; Kisa, Ucler; Olgun, Ebru
    Background: The aim of this study is to look into the clinical and biochemical outcomes of D3K2 supplementation in addition to nonsurgical periodontal treatment (NSPT) for patients suffering from diabetes mellitus (DM) and periodontitis. Methods: Thirty-eight participants with DM and periodontitis were randomized into two different groups. The test group provided NSPT with D3K2 whereas the control group received NSPT with placebo. Clinical periodontal parameters were recorded and serum and gingival crevicular fluid (GCF) were sampled at baseline and at the third and the sixth months after treatment. Glycated hemoglobin A1c (HbA1c), fasting blood glucose (FBG), 25(OH)D-3, parathyroid hormone (PTH), calcium (Ca) and magnesium (Mg) values were determined in blood samples. GCF and serum interleukin (IL)-1 beta and IL-10 levels were analyzed using enzyme-linked immunosorbent assay. Results: All clinical periodontal parameters were importantly decreased at the third and sixth months after treatment compared to baseline in both groups. At the sixth month, 25(OH)D-3 levels in the test group were observed to be statistically significantly higher than in the control group (p = 0.02). Serum IL-1 beta showed a statistically significant decrease at the sixth month compared to baseline and the third month in control group. Conclusion: According to this study, there is limited additional benefit of D3K2 given with NSPT in individuals with DM and periodontitis.
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    Non-functioning adrenal incidentalomas may increase toxic metabolites
    (Springer Wien, 2022) Karahan, Irfan; Ceylan, Senay Durmaz; Gungunes, Askin; Cifci, Aydin; Eker, Fatih; Kisa, Ucler
    Background Non-functioning adrenal incidentaloma (NFAI) is a frequent diagnosis with increasing radiological tests. The emerging shreds of evidence showed that they might have negative cardiometabolic effects. The study aimed to investigate whether the toxic metabolites, asymmetric dimethylarginine (ADMA) levels, were altered in NFAI patients. Methods We included 43 NFAI patients and 41 controls with similar ages and body mass indices in the study. We compared plasma ADMA levels of both groups and noted the radiological features of NFAIs. Results The ADMA levels were significantly higher in NFAI patients than in the control group (307.04 ng/ml, range 81.89-577.7 ng/ml vs 192.54 ng/ml, range 70.61-440.26 ng/ml, p = 0.001). Nevertheless, we could not reach a significant correlation between ADMA levels and mass size. Conclusion The ADMA is known as a toxin and is increased in NFAI patients. NFAIs may not be innocent and may be considered a potential risk for the body. Further investigations were needed for more explanations.
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    The Diagnostic Value of Soluble Triggering Receptor Expressed on Myeloid Cells for Patients with Acute Stone Pyelonephritis
    (Mdpi, 2024) Ozsoy, Metin; Ataman, Mirac; Sahin, Serhat Kazim; Senocak, Ibrahim; Varlibas, Artuner; Yuvanc, Ercan; Cifci, Aydin
    Soluble triggering receptor expressed on myeloid cells (sTREM-1) is a new biomarker that can be used for the diagnosis and monitoring of urinary system infections. This study aimed to evaluate the diagnostic performance of serum sTREM-1 in patients with a diagnosis of acute stone pyelonephritis (ASP). This prospective study included 46 patients with a diagnosis of ASP and a control group of 23 individuals without urinary system infection. Blood samples were taken from participants upon hospital admission, and basal serum sTREM-1 levels were analyzed using the ELISA method. Serum sTREM-1 concentrations were measured after treatment of ASP patients. Basal leukocyte counts, C-reactive protein (CRP) levels, procalcitonin (PCT), and sTREM-1 (98.6 vs. 68.4 pg/mL, p < 0.001) levels were higher in the ASP group compared to the control group. After treatment, the median leukocyte counts, PCT, and sTREM-1 levels decreased and were similar to those of the control group. The median CRP level also decreased after treatment, but it remained higher than that of the control group. In predicting patients with ASP, the baseline sTREM-1 exhibited a sensitivity of 74.6% and a specificity of 78.2%, while its diagnostic performance was lower than that of leukocyte counts, CRP, and PCT. Despite the findings that levels of sTREM-1 were higher upon hospital admission in patients with ASP and significantly decreased after treatment, the utility of sTREM-1 as a biomarker for predicting patients with ASP remains constrained when compared to established inflammatory markers.
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    Tumour budding in preoperative biopsy specimens is a useful prognostic index for identifying high-risk patients in early-stage (pN0) colon cancer
    (Tubitak Scientific & Technical Research Council Turkey, 2020) Zengin, Mehmet; Cifci, Aydin
    Background/aim: Tumour budding (RI)) is considered a valuable prognostic factor in colon cancer (CC), but its use in daily practice is uncertain. W investigated the prognostic effect of RI) using preoperative biopsy specimens in a fairly homogeneous population. Materials and methods: Eighty-two (pN0) CC patients vho underwent surgery after preoperative biopsy between 1997 and 2013 We re included in the study. Model A (using the 'deeply invasive blocks & hot -spot area & invasive margin) and method 1 (using the '20x objective & immunohistochemistry staining & quantitive counting') were used as standard methods. Results: High BD was significantly associated with poor prognostic factors (lymphatic invasion [P = 0.008], perineural invasion [P = 0.041], advanced pT [P = 0.015], invasive margin [P = 0.008], and margin involvement [P = 0.019]). Moreover, correlations between different BD estimates (r = 0.613-0.696), reproducibility of study (Kappa = 0.68-0.73), and usefulness of cut-off value (area of under ROC = 0.746 [0.663-0.8291) were well. In univariate analysis, 5 -year survival was poor in patients with high BD (relaps-free survival 1RfS I: 71 %, P < 0.001; overall survival I OS1: 73 %, P 0.004, local recurrence I I,R 1: 18 %, P = 0.032). Multivariate analyses confirmed that high BD is an independent worse survival parameter for RI S (1 lazard ratio [I IR]: 1.53 [1.14-2.80], P 0.015), OS (I IR: 1.44 11.17-2.751, P 0.032, and FR (I IR: 1.59 11.05-2.761, P 0.045). Conclusion: Our data show that BD provides valuable prognostic information for early-stage (pN0) CC in preoperative biopsy specimens and that adding RI) to current risk classification may contribute to better patient selection.