Tumour budding in preoperative biopsy specimens is a useful prognostic index for identifying high-risk patients in early-stage (pN0) colon cancer
Yükleniyor...
Tarih
2020
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Tubitak Scientific & Technical Research Council Turkey
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Background/aim: Tumour budding (RI)) is considered a valuable prognostic factor in colon cancer (CC), but its use in daily practice is uncertain. W investigated the prognostic effect of RI) using preoperative biopsy specimens in a fairly homogeneous population. Materials and methods: Eighty-two (pN0) CC patients vho underwent surgery after preoperative biopsy between 1997 and 2013 We re included in the study. Model A (using the 'deeply invasive blocks & hot -spot area & invasive margin) and method 1 (using the '20x objective & immunohistochemistry staining & quantitive counting') were used as standard methods. Results: High BD was significantly associated with poor prognostic factors (lymphatic invasion [P = 0.008], perineural invasion [P = 0.041], advanced pT [P = 0.015], invasive margin [P = 0.008], and margin involvement [P = 0.019]). Moreover, correlations between different BD estimates (r = 0.613-0.696), reproducibility of study (Kappa = 0.68-0.73), and usefulness of cut-off value (area of under ROC = 0.746 [0.663-0.8291) were well. In univariate analysis, 5 -year survival was poor in patients with high BD (relaps-free survival 1RfS I: 71 %, P < 0.001; overall survival I OS1: 73 %, P 0.004, local recurrence I I,R 1: 18 %, P = 0.032). Multivariate analyses confirmed that high BD is an independent worse survival parameter for RI S (1 lazard ratio [I IR]: 1.53 [1.14-2.80], P 0.015), OS (I IR: 1.44 11.17-2.751, P 0.032, and FR (I IR: 1.59 11.05-2.761, P 0.045). Conclusion: Our data show that BD provides valuable prognostic information for early-stage (pN0) CC in preoperative biopsy specimens and that adding RI) to current risk classification may contribute to better patient selection.
Açıklama
Anahtar Kelimeler
Tumour budding, colon cancer, preoperative biopsy, early-stage (pN0)
Kaynak
Turkish Journal Of Medical Sciences
WoS Q Değeri
Q4
Scopus Q Değeri
Q1
Cilt
50
Sayı
2
Künye
Zengin M., Çifci A. (2020). Tumour budding in preoperative biopsy specimens is a useful prognostic index for identifying high-risk patients in early-stage (pN0) colon cancer. Turkish Journal of Medical Sciences, 50(2), 375 - 385.
