Tumour budding in preoperative biopsy specimens is a useful prognostic index for identifying high-risk patients in early-stage (pN0) colon cancer

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dc.contributor.authorZengin, Mehmet
dc.contributor.authorCifci, Aydin
dc.date.accessioned2020-06-25T18:35:01Z
dc.date.available2020-06-25T18:35:01Z
dc.date.issued2020
dc.departmentKırıkkale Üniversitesi
dc.description.abstractBackground/aim: Tumour budding (RI)) is considered a valuable prognostic factor in colon cancer (CC), but its use in daily practice is uncertain. W investigated the prognostic effect of RI) using preoperative biopsy specimens in a fairly homogeneous population. Materials and methods: Eighty-two (pN0) CC patients vho underwent surgery after preoperative biopsy between 1997 and 2013 We re included in the study. Model A (using the 'deeply invasive blocks & hot -spot area & invasive margin) and method 1 (using the '20x objective & immunohistochemistry staining & quantitive counting') were used as standard methods. Results: High BD was significantly associated with poor prognostic factors (lymphatic invasion [P = 0.008], perineural invasion [P = 0.041], advanced pT [P = 0.015], invasive margin [P = 0.008], and margin involvement [P = 0.019]). Moreover, correlations between different BD estimates (r = 0.613-0.696), reproducibility of study (Kappa = 0.68-0.73), and usefulness of cut-off value (area of under ROC = 0.746 [0.663-0.8291) were well. In univariate analysis, 5 -year survival was poor in patients with high BD (relaps-free survival 1RfS I: 71 %, P < 0.001; overall survival I OS1: 73 %, P 0.004, local recurrence I I,R 1: 18 %, P = 0.032). Multivariate analyses confirmed that high BD is an independent worse survival parameter for RI S (1 lazard ratio [I IR]: 1.53 [1.14-2.80], P 0.015), OS (I IR: 1.44 11.17-2.751, P 0.032, and FR (I IR: 1.59 11.05-2.761, P 0.045). Conclusion: Our data show that BD provides valuable prognostic information for early-stage (pN0) CC in preoperative biopsy specimens and that adding RI) to current risk classification may contribute to better patient selection.en_US
dc.identifier.citationZengin M., Çifci A. (2020). Tumour budding in preoperative biopsy specimens is a useful prognostic index for identifying high-risk patients in early-stage (pN0) colon cancer. Turkish Journal of Medical Sciences, 50(2), 375 - 385.en_US
dc.identifier.doi10.3906/sag-1907-142
dc.identifier.endpage385en_US
dc.identifier.issn1300-0144
dc.identifier.issn1303-6165
dc.identifier.issue2en_US
dc.identifier.pmid32011836
dc.identifier.scopus2-s2.0-85083538583
dc.identifier.scopusqualityQ1
dc.identifier.startpage375en_US
dc.identifier.trdizinid334425
dc.identifier.urihttps://doi.org/10.3906/sag-1907-142
dc.identifier.urihttps://hdl.handle.net/20.500.12587/8099
dc.identifier.volume50en_US
dc.identifier.wosWOS:000525954500014
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTubitak Scientific & Technical Research Council Turkeyen_US
dc.relation.ispartofTurkish Journal Of Medical Sciences
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectTumour buddingen_US
dc.subjectcolon canceren_US
dc.subjectpreoperative biopsyen_US
dc.subjectearly-stage (pN0)en_US
dc.titleTumour budding in preoperative biopsy specimens is a useful prognostic index for identifying high-risk patients in early-stage (pN0) colon canceren_US
dc.typeArticle

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