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Öğe Effect of ovarian activity on orthodontic tooth movement and gingival crevicular fluid levels of interleukin-1 beta and prostaglandin E-2 in cats(E H Angle Education Research Foundation, Inc, 2013) Celebi, Ahmet Arif; Demirer, Serhat; Catalbas, Bulent; Arikan, SevketObjective: To evaluate whether there is any correlation between ovarian activity and two potent bone-resorbing mediators (prostaglandin E-2 [PGE(2)], interleukin-1 beta [IL-1 beta]) secreted from the gingival crevicular fluid (GCF) during orthodontic tooth movement. Materials and Methods: Eighteen female cats were included in this study. Animals were randomly divided into three groups (estrous, anestrous, and ovariectomized groups), each having six queens. Estrous was induced by administration of 150 IU equine chorionic gonadotropin (eCG) to queens of the estrous group. A closed-coil spring, applied with 80 g of tipping force to the canine, was attached between the maxillary canine and mini-implant. GCF was collected on days 0, 6, and 12 from each cat to examine PGE(2) and IL-1 beta during orthodontic tooth movement in cats. The PGE(2) and IL-1 beta levels were determined with enzyme-linked immunosorbent assay. Results: There was no significant difference (P > .05) between anestrous and the ovariectomized groups in terms of tooth movement on days 6 and 12 of distalization. In contrast, tooth movement in the estrous group was lower (P < .05) than in the remaining two groups (anestrous and ovariectomized). The mean PGE(2) and IL-1 beta levels of the canine teeth of the estrous groups were significantly lower than the remaining two groups on days 6 and 12 (P < .05) of coil spring applications. Conclusions: These results indicate that ovarian activity can affect orthodontic tooth movement and GCF levels of IL-1 beta and PGE(2) in cats. (Angle Orthod. 2013;83:70-75.)Öğe Effects of boric acid on experimental periodontitis and alveolar bone loss in rats(Pergamon-Elsevier Science Ltd, 2012) Demirer, Serhat; Kara, M. Isa; Erciyas, Kamile; Ozdemir, Hakan; Ozer, Hatice; Ay, SinanObjective: The goal of the present study was to evaluate the histopathologic and morphometric effects of systemic boric acid in a rat periodontitis model. Design: Twenty-four Wistar rats were divided into three groups of eight animals each: non-ligated (NL), ligature only (LO), and ligature and treated with boric acid (BA) (3 mg/kg per day for 11 days). A 4/0 silk suture was placed in a subgingival position around the mandibular first molars; after 11 days the rats were sacrificed, and changes in alveolar bone levels were measured clinically and tissues were histopathologically examined to assess the differences amongst the study groups. Results: The ratio of presence of inflammatory cell infiltration (ICI) and osteoclast number in the LO group was significantly higher than that of the NL and BA groups (p < 0.05). The ratio of presence of osteoblastic activity in the LO group was significantly lower than that of the NL and BA groups (p < 0.05). Alveolar bone loss was also significantly higher in the LO group compared to the BA and NL groups (p < 005). Conclusions: This study has demonstrated that systemic administration of boric acid reduced periodontal inflammation and alveolar bone loss in periodontal disease in rats. (C) 2011 Elsevier Ltd. All rights reserved.Öğe Effects of Orthodontic Treatment on Patients' Dental Anxiety and Oral Health Knowledge(Aves Press Ltd, 2009) Ozturk, Firat; Sokucu, Oral; Demirer, Serhat; Nalcaci, Ruhi; Ozdemir, HakanThe aim of this study was to investigate effects of orthodontic treatment on both anxiety and oral health knowledge of orthodontic patients. The study was carried out in 184 patients. Four groups were formed according to the stage of orthodontic treatment. Group 1 consisted of 47 individuals selected from patients who were awaiting orthodontic treatment; groups 2 and 3, comprised 44 and 46 individuals who had been undergoing orthodontic treatment for a period of 1-12 and 12-26 months respectively, and group 4, 47 orthodontically treated individuals. The modified Dental Anxiety Scale was used to measure dental anxiety. Oral health knowledge was assessed using several questions concerning etiology, symptoms and prevention. Chi-squire test was used for statistical assessment. The anxiety level of patients in group 1 was significantly higher than the subjects in group 4. Patients in groups 2, 3 and 4 mostly knew that gum bleeding is a sign of periodontal disease (81.8, 84.7, 80.1 per cent respectively); and this was 63.8 per cent for group 1. Patients in all groups were aware how to prevent, however those who were undergoing or had completed treatment were more informed about symptoms of periodontal disease. Only 19.6 and 52.1 per cent of subjects in group 3 had the knowledge to identify dental plaque and what it can cause respectively; which was the highest ratio among the groups. Orthodontic treatment involves some degree of exposure, consequently creates a positive influence on patients' anxiety and periodontal health knowledge.Öğe Evaluation of the adjunctive effect of platelet-rich fibrin to enamel matrix derivative in the treatment of intrabony defects. Six-month results of a randomized, split-mouth, controlled clinical study(Wiley, 2016) Turkal, Humerya Aydemir; Demirer, Serhat; Dolgun, Anil; Keceli, Huseyin GencayAim: This study aimed to compare the results obtained with enamel matrix derivative (EMD) and EMD + platelet-rich fibrin (PRF) in the treatment of intrabony defects (IBDs) in chronic periodontitis patients. Materials and Methods: Using a split-mouth design, 28 paired IBDs were randomly treated either with EMD or with EMD + PRF. Clinical and radiographic measurements including clinical attachment level (CAL), probing depth (PD), gingival recession (GR), defect depth (DD), defect width (DW) and defect angle (DA) were recorded at baseline (BL) and at six months following therapy. Results: BL clinical and radiographic measurements were similar for EMD and EMD + PRF groups. Although postsurgical measurements revealed significant reduction for PD and CAL in both groups, no intergroup difference was detected. When EMD and EMD + PRF groups were compared, defect fill was not also statistically different. Conclusions: Both therapies resulted in significant clinical improvement in IBD treatment. Addition of PRF did not improve the clinical and radiographic outcomes.Öğe Ortodontik tedavinin hastaların dişsel kaygı seviyesi ve oral sağlık bilgisi üzerine etkisi(2009) Öztürk, Fırat; Sökücü, Oral; Demirer, Serhat; Nalçacı, Ruhi; Özdemir, HakanBu çalışmanın amacı, ortodontik tedavinin bireylerin diş tedavisi ile ilgili kaygı ve oral sağlık bilgisi üzerine olan etkilerini araştırmaktır. Çalışma ortodontik tedavi safhalarına gore 4 gruba ayrılmış toplam 184 birey üzerinde yürütüldü. Birinci gurup ortodontik tedavi olmak için .sırada bekleyen 47 bireyden; İkinci gurup ortodontik tedavinin ilk yılında ( I-T2 ay) bulunan 44 bireyden, Üçüncü grup ortodontik tedavisi 12-26 aydır devam etmekte olan 46 bireyden, Dördüncü gurup ise ortodontik tedavisi bitmiş 47 bireyden oluşturuldu. Dişsel kaygı düzeyi, uyarlanmış dişsel kaygı ölçeği ile saptandı. Bireylerin ağız sağlığı ile ilgili bilgi düzeyi ise koruyucu tedavi, semptom veet-yolpjiye yönelik olarak hazırlanmış bir anketle değerlendirildi. İstatistiksel değerlendirmede ki-kare testi kullanıldı. Birinci gruptaki bireylerin kaygı seviyesi dördüncü gruptaki bireylere göre belirgin bir şekilde yüksek olarak bulundu. Birinci gruptakilerin haricindeki bireylerin çoğu dişeti kanamasının periodontal hastalık belirtisi olduğunu biliyordu (sırasıyla %81.8, %84.7, %80.1), ki bu oran birinci' gruptaki bireyler için %63.8 di. Tüm grupla rdakr .bireylerin koruyucu tedavi hakkındaki bilgileri, aynı olmasına rağmen, periodontal hastalığın belirtileri hakkında ortodontik tedavisi bitmiş veya ortodontik tedavi görmekte olan bireyler daha fazla bilgili olduğu görülmüştür. Periodontal hastalığın beliıtileri hakkında en fazla, bilgiye sahip olan 3. guruptaki bireylerin %19.6 ve %52.1y i dental plağı saptayabiliyor ve buna neyin sebep olacağını da biliyordu. Ortodortlik tedavi bazı safhalarında farklı dental uygulamaları da içerdiği için dental kaygı üzerinde pozitif bir etkiye sahiptir. (Türk Ortodonti Dergisi 2009;22:228-235)Öğe Periodontal Healing of Marginal Flap Versus Paramarginal Flap in Palatally Impacted Canine Surgery: A Prospective Study(W B Saunders Co-Elsevier Inc, 2009) Kosger, Hueseyin; Polat, Hidayet B.; Demirer, Serhat; Ozdemir, Hakan; Ay, SinanPurpose: The aim of the present study was to compare the influence of 2 mucoperiosteal flaps, marginal and paramarginal, on the periodontal healing of adjacent maxillary teeth after extraction of palatally impacted canines. Patients and Methods: Marginal (15 patients) and paramarginal (16 patients) techniques were used to remove palatally impacted canines. The periodontal examination of the adjacent teeth included evaluation of the plaque index, gingival index, probing depth, and clinical crown length preoperatively and at the first, third, and sixth months postoperatively using an individual acrylic stent. Results: No significant differences between the marginal and paramarginal flaps were found with respect to plaque index, gingival index, labial and palatal probing depth, and labial and palatal clinical crown length at all follow-up points. Conclusion: The results of our study have shown that the paramarginal flap design is a good alternative to the marginal flap design. (C) 2009 American Association of Oral and Maxillofacial Surgeons J Oral Maxillofac Surg 67: 1826-1831, 2009Öğe The Relationship of Orthodontic Treatment Need with Periodontal Status, Dental Caries, and Sociodemographic Factors(Hindawi Publishing Corporation, 2012) Nalcaci, Ruhi; Demirer, Serhat; Ozturk, Firat; Altan, Burcu A.; Sokucu, Oral; Bostanci, VildanThe aim of this study was to determine the relationship of orthodontic malocclusion with periodontal status, dental caries, and sociodemographic status. Our study population consisted of a sample of 836 school children (384 male and 452 female, aged 1114 years). Four experienced orthodontists and two experienced periodontists performed the clinical examinations. The Treatment Priority Index (TPI), Community Periodontal Index of Treatment Needs (CPITN), decayed, missing, filled teeth (DMFT) scores, and a questionnaire that surveyed socio-demographic status of students were used. Spearman's rank correlation coefficients were used to measure the association between variables. TPI scores showed that 36.4% of the students had normal occlusion, while 41.2% had slight, 15.7% had definite, 4% had severe, and 2.7% had very severe malocclusion. TPI values did not show any significant differences between pupils in different age, gender, socioeconomic status groups, and CPITN scores, whereas there was a significant relationship between TPI and DMFT scores. The orthodontic treatment need was not significantly correlated with CPITN or socio-demographic status; however, the correlation coefficient showed a significant relationship between TPI and DMFT scores.Öğe The role of nickel accumulation and epithelial cell proliferation in orthodontic treatment-induced gingival overgrowth(Oxford Univ Press, 2007) Gürsoy, Ulvi Kahraman; Sokucu, Oral; Uitto, Veli-Jukka; Aydin, Ahmet; Demirer, Serhat; Toker, Hülya; Sayal, AhmetThe aim of this study was to investigate the role of nickel in orthodontic treatment-induced gingival hyperplasia. The nickel concentration in gingival tissues with and without overgrowth, histopathology of gingival overgrowths, and epithelial cell proliferation response to different nickel concentrations were analysed. Ten patients receiving orthodontic therapy (eight females and two males, mean age 15.4 years) were included in the study. Hyperplastic and healthy gingiva samples were collected from the same patients. The amount of nickel in the gingival tissue samples was analysed using the atomic absorption spectrometry technique. The tissues removed from hyperplastic areas during gingivectomy were also used for histological analysis. To analyse the effect of nickel on epithelial cell proliferation, four different nickel concentrations (0.5, 2, 5, and 10 mu g) were incubated with keratinocyte cells for 11 days. Mann-Whitney U-test, analysis of variance, and Tukey's test were used in the statistical analyses. The results did not show any difference in nickel concentration between the study and control gingiva tissue samples, but histological analysis demonstrated an increase in epithelial thickness and a significant increase (P = 0.031, 0.02, 0.02) in epithelial cell proliferation in response to low-dose nickel concentrations, with a toxic response to a higher dose. In the limitations of this study, it is plausible that the effect of a continuing low-dose nickel release to epithelium is the initiating factor of gingival overgrowth induced by orthodontic treatment.
