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    Öğe
    Early Inflammation Related to Pediatric Obesity
    (Aves Yayincilik, Ibrahim Kara, 2023) Derhem, Baki; Karahan, İrfan
    Objective: Obesity is a serious health problem, has reached pandemic proportions and represents a major risk for several comorbidities. Some of the serum markers are considered to be associated with low-grade chronic inflammation. Neutrophil to lymphocyte ratio (NLR) is a new and cost-effective marker for the detection of subclinical inflammation that correlates with C-reactive protein (CRP) levels. The objectives of this study were to examine the relation between children's BMI and the bio-markers of early inflammatory predictors.Material and Methods: The retrospective study included 176 children aged 5-18 years who applied to a primary care setting in Turkiye be-tween January 2019 and March 2019. Participants with BMIs between 85-95 percentiles were defined as overweight and those over 95 per-centiles as obese. For all groups, hemogram parameters, cell volumes, and ratios were evaluated and compared. In addition, NLR and PLR were compared.Results: We found that neutrophil count and NLR were significantly different between the normal weight and overweight/obese groups (p= 0.001, p< 0.001 respectively) while hemoglobin, WBC, MPV, MCV, RDW, and PLR were similar in hemogram evaluation.Conclusion: Obesity is associated with low-grade inflammation levels and is reaching alarming rates among both children and adults. Our study suggested that neutrophil counts and NLR were significantly higher in overweight/obese children. Obesity-related studies involving pediatric patients are crucial to developing appropriate methods for preventing the development of further complications in adulthood.
  • [ X ]
    Öğe
    Investigation of choroidal structure changes after intravitreal anti-VEGF therapy for retinal vein occlusion
    (Springer, 2024) Dursun, Erdem; Derhem, Baki; Cobanoglu, Seval; Ogurel, Tevfik
    Background We aimed to investigate the effect of retinal vein occlusion (RVO) on the posterior segment structures of the eye and its changes with intravitreal anti-Vascular Endothelial Growth Factor (VEGF) treatment. Methods This prospective longitudinal study included 29 eyes of 29 patients with RVO (17 males and 12 females) followed for 6 months. The best corrected visual acuity (BCVA), macula, choroid ticknesses and choroidal vascularity index (CVI) obtained by spectral-domain optical coherence tomography were recorded at baseline and the first, third, and sixth months after the first injection. Results were compared with fellow eyes (non-affected eyes) and age- and sex-matched controls. Results BCVA increased significantly in the 6th month, more in the first month of injection (p < 0.05 for each). Central macular tickness, subfoveal choroid tickness, stromal and total area of choroid decreased significantly after injection (p < 0.05 for each). CVI values increased significantly, especially in the 1st month after injection (p < 0.05 for each). In eyes with Branch RVO, there was a significant decrease in the macular thickness of the occlusive areas with treatment, while there was no statistically significant change in the non-occlusive macular thickness. Conclusion Observation of changes in choroidal structure may be useful to assess the activity of RVO and predict the efficacy of anti-VEGF therapy.