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A Case of Miliary Tuberculosis Detected with Laryngeal Oedema: Complication with Septic Shock and Thrombocytopaenia
(Aves, 2013) Bulcun, Emel; Ekici, Aydanur; Ekici, Mehmet; Gulhan, Pinar Yildiz; Gungor, Omur; Kazkayasi, Mustafa
Tuberculosis, a disease with a wide clinical spectrum, can involve all tissues and organs. A 57-year-old case appeared in the form miliary tuberculosis after laryngeal oedema. Septic shock developed in the course of tuberculosis. Thrombocytopaenia then developed, while septic shock improved following antituberculosis treatment. Thrombocytopaenia improved after rifampicin was removed from the treatment regimen. We decided to present our case here as an interesting form of tuberculosis with complications.
Adverse effect of VEGFR-2 (rs1870377) polymorphism on the clinical course of COVID-19 in females and males in an age-dependent manner
(Elsevier, 2023) Kocakap, Derya Beyza Sayin; Kaygusuz, Sedat; Aksoy, Emel; Sahin, Omer; Baccioglu, Ayse; Ekici, Aydanur; Kalpaklioglu, Ayse Fusun
The COVID-19 pandemic has affected people worldwide with varying clinical presentations ranging from mild to severe or fatal, and studies have found that age, gender, and some comorbidities can influence the severity of the disease. It would be valuable to have genetic markers that might help predict the likely outcome of infection. For this objective, genes encoding VEGFR-2 (rs1870377), CCR5D32 (rs333), and TLR3 (rs5743313) were analyzed for polymorphisms in the peripheral blood of 160 COVID-19 patients before COVID-19 vaccine was available in Turkiye. We observed that possession of the VEGFR-2 rs1870377 mutant allele increased the risk of severe/moderate disease in females and subjects >= 65 years of age, but was protective in males <65 years of age. Other significant results were that the CCR5D32 allele was protective against severe disease in subjects >= 65 years of age, while TLR3 rs5743313 polymorphism was found to be protective against severe/moderate illness in males <65 years of age. The VEGFR-2 rs1870377 mutant allele was a risk factor for severe/moderate disease, particularly in females over the age of 65. These findings suggest that genetic polymorphisms have an age-and sex-dependent influence on the severity of COVID-19, and the VEGFR-2 rs1870377 mutant allele could be a potential predictor of disease severity.(c) 2023 Institut Pasteur. Published by Elsevier Masson SAS. All rights reserved.
Affect status and perception of exacerbation in patients with asthma
(Ocean Side Publications Inc, 2010) Ekici, Aydanur; Ekici, Mehmet; Bulcun, Emel
Exacerbations occur commonly in patients with asthma but factors affecting perception of dyspnea during exacerbation are not well known. This investigation was designed to determine the effects of negative mood on perception of dyspnea during exacerbation. A total of 47 patient aged 28-78 years (mean age, 52.5 years) admitted with acute asthma had recordings of blood gas pressure, negative mood score, forced expiratory volume in 1 second (FEV1), and dyspnea score at admission and at the 72nd hour. Perceived intensity of dyspnea was estimated using a modified Borg scale. The negative mood was assessed with an overall of six mood adjectives (nervous-anxious, sad-blue, and tired-drowsy). High negative mood score was defined as the score above the cutoff point (median score, >7). Borg sore of patients with a high negative mood score was higher than that of patients with a low negative mood score (6.3 +/- 2.5 versus 4.4 +/- 2.4; p +/- 0.01). The high Borg sore of asthmatic patients with high negative mood persisted even at the 72nd hour (1.6 +/- 0.9 versus 1.0 +/- 0.7; p +/- 0.01). FEV1 values of both groups at admission were similar. The negative mood score (beta = 0.68; p = 0.0001) and initial FEV1 (beta = -0.42; p = 0.01) were the important determinants of Borg score at admission in all patients with multivariate analysis but not arterial oxygen pressure, arterial carbon dioxide pressure, asthma duration, and female sex. This study indicated that emotional factors, as well as the level of airways obstruction, predicted the magnitude of dyspnea at exacerbation of asthmatic patients. Thus, the emotional factors should be taken into account in the treatment of dyspnea at exacerbation.
Assessment of patients' preferences regarding the characteristics associated with the treatment of chronic obstructive pulmonary disease
(Dove Medical Press Ltd, 2014) Bulcun, Emel; Ekici, Mehmet; Ekici, Aydanur
Objective: Patient preferences regarding characteristics associated with the treatment of chronic obstructive pulmonary disease (COPD) must be determined to increase the compatibility between the patients and the treatments, but as yet no studies have been performed regarding these characteristics. Here, we evaluate the preferred characteristics associated with the treatment of patients with COPD. Method: The expectations of patients receiving COPD therapy were assessed in six categories: time allocated by the physician to listen to patients' complaints, treatment to be applied, estimated adverse effect frequency concerning the therapy, ability of patients to visit the same physician each time, integral approach of the physician to the treatment of the patient, and therapy cost. These groups were divided into categories of therapy indicating 25 alternative treatment methods, using conjoint analysis. Patients were sorted to the 25 types of treatment with regard to their preferences. Results: The major expectation of conjoint analysis associated with the treatment of COPD patients is for the therapy to allow the patients to completely recover from their complaints. The order preferred by patients of other treatment expectations is from sufficient time to be allowed by the physician to listen to the patient, to no cost for the treatment, to minimum adverse effects resulting from the treatment, to each follow-up to be performed by the same physician, and to the physician performing an assessment of the patient's well-being, rather than examining only the areas of complaint. Conclusion: The major expectation of COPD patients regarding treatment was to completely recover with the help of the therapy. Considering the expectations of the patient may help improve the compatibility of the patient with the treatment.
Attention Deficit/Hyperactivity Disorder in Adults with Sleep Apnea
(Springer/Plenum Publishers, 2013) Oguzturk, Omer; Ekici, Mehmet; Cimen, Dilay; Ekici, Aydanur; Senturk, Erol
AAttention deficit hyperactivity disorder (ADHD) is a common childhood illness. In some patients, this illness may persist into adulthood and an association between ADHD and Obstructive Sleep Apnea (OSA) has been found in childhood. However, it is unclear how OSA and ADHD coincide in adulthood. Therefore, to explore the relationship between OSA and adult ADHD the current investigation utilized a clinically-based cross-sectional survey. Subjects consisted of 81 treatment-na < ve OSA patients and 32 controls. Measures included each patient completed a questionnaire regarding sleep, Adult ADHD scale. Clinical information, body mass index, 36-item Short Form Health Survey (SF-36), Epworth Sleepiness Scale (ESS), Hospital Anxiety and Depression Scale, and polysomnography.The subjects with Apnea-Hypopnea Index (AHI) a parts per thousand yen 5 events/h were defined as patients with OSA. The control group was accepted as individuals with AHI > 0 events/h. The prevalence of adult ADHD was not different between the patients with OSA and the control group [(7.4 % (6/75) vs. 6.3 % (2/30), p = 0.8, respectively]. OSA patients with ADHD, as compared with those without, had higher anxiety scores and poorer physical component scores of quality of life and higher ESS scores. ADHD scores in patients with OSA were associated with anxiety and depression scores and SF36 physical and mental component scores in bivariate analyses. Thus, in our sample ADHD was not a frequent illness in adult patients with OSA. However, in patients with OSA and ADHD higher levels of anxiety and daytime sleepiness and poorer quality of life was found.
Bir Olgu Sunumu: Hipersensitivite Pnömonisi
(2016) Bulcun, Emel; Ekici, Aydanur; Ekici, Mehmet; Çifci, Aydın; Cerit, Ahu
Nefes darlığı, öksürük semptomları ile gelen PA akciğer grafisi doğal olan ancak detaylı anamnezle güvercin maruziyeti öyküsü tarifleyen ve hipersensitivite pnömonisi tanısı alan olguyu sunduk. 66 yaşında erkek hasta üç aydır olan nefes darlığı, öksürük şikayetleri ile polikliniğine başvurdu. Fizik muayenesinde solunum sesleri doğaldı. Çevresel, mesleksel maruziyet ve özellikli bir ilaç kullanım öyküsü yoktu. PA akciğer grafisi normaldi. Toraks yüksek çözünürlüklü bilgisayarlı tomografi (YÇBT)'de orta ve alt loblarda daha belirgin olan yaygın buzlu cam dansitesinde sentriasiner nodüller izlendi. Hastanın evin çatısındaki güvercinlere ait atık ürünlerini haftalık temizlediği öğrenilmesi üzerine güvercinlerle direk ve dolaylı maruziyetinin kesilmesi önerildi. Bir ay sonraki kontrolünde öksürük ve nefes darlığı semptomlarında gerileme olduğu öğrenildi. Kontrol toraks YÇBT'de her iki akciğerde izlenen yaygın sentriasiner nodüllerin kaybolduğu görüldü. Nefes darlığı, öksürük gibi semptomlarla başvuran hastalarda akciğer grafisi normal bile olsa hipersensitivite pnömonisinin de olabileceği göz önünde bulundurulmalı ve hastaların maruziyet öyküsü detaylı olarak sorgulanmalıdır
Bronş astımlı hastalarda sinonazal patolojik bulgular
(2002) Kazkayası, Mustafa; Ekici, Aydanur; Yılmaz, Sevda; Muluk, Nuray Bayar; Koç, Can
Bronş astımlı hastalarda sinüslerde patolojik bulgulara daha sık rastlandığı ve kronik sinüzit (KS) tedavisinin astım semptomlarına ve akciğer fonksiyonlarına faydalı olduğu yüzyıllardır iddia edilmektedir. Bu çalışma, bronş astımı (BA) ve sinüslerdeki patolojik bulguların birlikte seyrini değerlendirmek amacıyla planlanmıştır. Fakültemiz KBB-BBC ve Göğüs Hastalıkları Polikliniklerinde Eylül 1999-Mart 2001 tarihleri arasında ayaktan takip edilen 75 BA’lı olgu çalışma grubunu oluşturmuştur. Göğüs Hastalıkları Polikliniğinde hastaların ayrıntılı fizik muayeneleri yapılmış ve klinik takibinde gündüz skoru, gece skoru, öksürük skoru ve inhale b2 agonist tüketimi ‘astım semptom skoru’ olarak "0 ile 16" arasında derecelendirilmiş ve solunum fonksiyon ölçümleri yapılmıştır. KBB-BBC polikliniğinde öyküleri alınan, fizik muayeneleri yapılan olguların paranazal sinus bilgisayarlı tomografi (PNS-BT)’leri çekilmiştir. Olguların BT toplam skorlama sonuçları ile solunum fonksiyon testi sonuçları karşılaştırılmıştır. BT çekilen olgularımızın %93.8’de sinonazal patolojik bulgu tespit edilmiştir. BT skorlama değerleri olguların yaş, astım semptom süresi, astım semptom skoru ve solunum fonksiyon testleri ile karşılaştırıldığında istatistiksel olarak anlamlı bir bulgu elde edilmemiştir (pé0.05). Çalışmamızda olgularımızın büyük çoğunluğunda sinonazal patolojik bulgu tespit edilmekle birlikte, sinüs hastalığının şiddeti ile BA şiddeti arasında pozitif bir ilişkinin olmadığı gözlenmiştir.
Case of round pneumonia: pulmonary infarct and a rare situation that is similar with the lung cancer
(Wiley-Blackwell, 2015) Cimen, Dilay; Bulcun, Emel; Ekici, Aydanur; Gungor, Omur; Ekici, Mehmet
Background and AimsRound pneumonia (RP) is a rare radiological presentation of a subtype of lobar pneumonia that arises because of a developmental defect in connective tissues (pores of Kohn and channels of Lambert). The round appearance on chest X-ray (CXR) is thought to occur from an infectious process that spreads from small peripheral alveoli centrifugally through interalveolar channels via the pores of Kohn and the canals of Lambert. This explains the nonsegmental distribution and shape of RP. The pathogenesis of RP is unknown. An alternative theory holds that RP in children occurs because of underdeveloped pores of Kohn and the absence of canals of Lambert, limiting the spread of the organism and resulting in a focal, round mass seen on radiographs. As a result of this developmental defect, dissemination of infection remains in a limited area. While this is a well-known entity in childhood, it has been described infrequently in adults. Lesions of RP are not necessarily round; oval lesions can also be seen. It is a radiological subtype of the pneumonia subtype and presents as a solitary nodule or a mass lesion in CXR. MethodsWe presented two cases of RP. One mimicked and was mistaken for pulmonary infarction because of triangular pleural-based density and the other mimicked pulmonary malignancy because of a homogeneous triangular opacity based on the pleura on the posteroanterior radiography and computed tomography. ConclusionThese cases were presented because of RP's importance, and RP should be considered a part of differential diagnosis of pulmonary infarct and lung tumor.
Chronic airway diseases in adult life and childhood infections
(Karger, 2008) Ekici, Mehmet; Ekici, Aydanur; Akin, Ahmet; Altinkaya, Volkan; Bulcun, Emel
Background: Respiratory disorders in childhood may predispose to pulmonary disease in late adult life. Objectives: The aim of this study was to evaluate the relationship between their effects in adult life and the characteristics of the respiratory system in childhood. Methods: A total of 10,224 parents and grandparents of students from 14 randomly selected primary schools in the city center were asked to answer questionnaires given to their children. 9,853 of 10,224 persons (the overall response rate was 96.3%) were eligible for analysis. In the questionnaire subjects were asked about respiratory system-related symptoms and characteristics. Results: Chronic cough [14.3 vs. 4.7%, OR 3.4 (2.6 - 4.4), p < 0.001], chronic bronchitis [35.3 vs. 11.8%, OR 4.0 (3.4 - 4.8), p ! 0.001] and asthma [34.2 vs. 5.1%, OR 9.6 (8.0 - 11.5), p < 0.001] in the childhood respiratory infection group were more common than in the control group. Childhood respiratory infections were associated with an increased risk of asthma (OR 5.6, p < 0.001), chronic bronchitis (OR 2.3, p < 0.001) and chronic cough (OR 1.5, p < 0.001), after adjusting for possible confounding factors. In addition, the presence of dampness or visible mould, wall-to-wall carpets, pets at home and parents' smoking during childhood were associated with an increased risk of frequent childhood respiratory infections. Conclusion: These results indicated that frequent respiratory infections during childhood might play an important role in the occurrence of chronic airway diseases in adult life. The removing of risk factors for frequent childhood respiratory infections may reduce the subsequent risk of chronic airway disease in late adult life. Copyright (C) 2007 S. Karger AG, Basel.
Chronic CT features in PE patients with co-existing DVT
(W B Saunders Co-Elsevier Inc, 2021) Ekici, Mehmet; Ekici, Aydanur; Ileri, Sule
Objective: Clinical features may be different in patients with PE without co-existing DVT compared to those with PE with co-existing DVT. This prospective study aims to investigate the different clinical features between patients with isolated pulmonary embolism (PE) and those with PE associated with deep venous thrombosis. Method: This is a prospective study conducted in 107 consecutive patients diagnosed with acute PE in the emer-gency department or other departments of Kirikkale University Hospital. The diagnosis of PE was confirmed by computed tomography pulmonary angiography (CTPA), which was ordered on the basis of symptoms and find-ings. Bilateral lower extremity compression ultrasound with standard 7.5 MHz linear array probe was applied to all patients. According to compression ultrasound results, the patients were divided into two classes as with and without deep venous thrombosis. Embolism in the main or lobar pulmonary arteries were classified as central, and those found only in segmental or subsegmental arteries were classified as peripheral. Laboratory parameters and Oxygen saturation were assessed on admission. Results: 67 of 107 (62.6%) patients with PE were isolated pulmonary embolism, and 40 (37.4%) were PE + DVT. Patients with PE with co-existing DVT have wider pulmonary artery, higher d-dimer and pro BNP level, and lower saturation than those with isolated pulmonary embolism. Central pulmonary embolism is more common in patients with deep vein thrombus than those without it. (87.5% (35/40) vs 32.8% (22/67),p = 0.001). 38.6% of central pulmonary embolism occur without deep vein thrombosis of the lower extremities. Patients with PE with co-existing DVT have 42.5% mosaic perfusion pattern,70% chronic infarct appearance such as linear band, pleural nodule, %15.0 thickened, small arteries and, %12.5 shrunken complete artery occlusion, suggesting the chronic background. Conclusion: PE patients with co-existing DVT are clinically more serious than those who do not have a DVT. An acute picture may be present in the chronic background in a significant proportion of patients with PE with co-existing DVT. In the presence of deep vein thrombosis, pulmonary embolism is usually central, but more than one-third of central pulmonary emboli occur without lower extremity deep vein thrombosis. (c) 2021 Published by Elsevier Inc.
CT assessment of the effect of fluticasone propionate aqueous nasal spray treatment on lower turbinate hypertrophy due to vasomotor rhinitis
(Taylor & Francis Ltd, 2006) Arıkan, Osman Kürşat; Koç, Can; Kendi, Tuğba; Muluk, Nuray Bayar; Ekici, Aydanur
Conclusion. Fluticasone propionate ( FP) aqueous nasal spray was objectively found to be effective and safe for the treatment of lower turbinate enlargement in patients with vasomotor rhinitis. Objective. To assess the efficacy of FP aqueous nasal spray treatment in lower turbinate hypertrophy due to vasomotor rhinitis using CT. Material and methods. Of 35 patients with hypertrophic lower turbinates due to vasomotor rhinitis, 20 were treated twice daily with FP aqueous nasal spray ( 200 mu g/day) for 3 months continuously and 15 were treated with placebo vehicle as a control group. The local effect of the nasal spray was studied using CT and visual analog scales. Results. Treatment with FP provided significantly greater relief from the symptom of nasal obstruction compared with placebo over the entire 3-month treatment period ( p< 0.001). When the change from baseline was compared between the two groups, FP produced statistically significant reductions in the mucosal area of the lower turbinates and in the thickness of the nasal mucosa after 3 months (p< 0.05).
Effect of psychological on respiratory symptoms
(2005) Ekici, Aydanur; Oğuztürk, Ömer; Ekici, Mehmet; Kurtipek, Ercan; Akın, Ahmet; Arslan, Mesut; Tunçkol, Müge
Amaç: Psikolojik durumun solunum semptomu bildirmeye ve solunum sisteminin objektif ölçümlerine etkisinin olup olmadığını araştırdık. Materyal ve Metotlar: Çalışmaya silah fabrikasında çalışan 1090 erkek işçi ve biomasse maruz kalan 420 kadın alındı. Olgular respiratuar sorgulama formu ile sorgulanarak portable spirometre cihazı ile solunum fonksiyonları ölçüldü.Psikolojik durum HAD scalası ile ölçülerek ;median değere göre yüksek ve düşük HAD total skorlu gruplar olarak sınıflandırıldılar. Bulgular: Erkeklerde: Kronik öksürük (%17,6 vs %10,7 p0,001), Kronik balgam (13,2% vs.8,9%, p0,02) ve muhtemel astım (%39,5 vs %25,5, p0,0001) yüksek HAD total skorlu grupta düşük HAD total skorlu grupa göre önemli olarak daha sık bulunurken kesin astım (%6,2 vs %4,6, p0,2) için gruplar arasında fark yoktu. Kadınlarda: Kronik öksürük (%34,8 vs %23,5 p0,009), kronik balgam (%23,9 vs. %15,4, p0,02) ve muhtemel astım (%53,5 vs %35,3, p0,0001) yüksek HAD total skorlu grupta düşük HAD total skorlu grupa göre önemli olarak daha sık bulunurken kesin astım (%7,0 vs %9,0, p0,4) için gruplar arasında fark yoktu. Sonuç: Respiratuar sorgulamada semptom bildirme sıklığı psikolojik durumdan etkilenebilir.Respiratuar sorgulama ve psikolojik durum göstergeleri eşzamanlı olarak yorumlanmalıdır.
EFFECT OF PSYCHOLOGICAL STATUS ON RESPIRATORY SYMPTOMS
(Gazi Univ, Fac Med, 2005) Ekici, Aydanur; Oguzturk, Omer; Ekici, Mehmet; Kurtipek, Ercan; Akin, Ahmet; Arslan, Mesut; Kara, Turkan
Objective: To investigate whether psychological status affects respiratory symptom reporting and objective measures of the respiratory system. Materials and Methods: This study was performed in 1090 male gun factory workers and in 420 women exposed to biomass. The subjects were questioned using a Respiratory questionnaire. Respiratory functions were measured by portable spirometer. Psychological status was measured by HAD scale. Groups with high HAD total scores and low HAD total scores were classified by the median value. Results: In males: Chronic cough (17.6% vs. 10.7% p=0.001), chronic phlegm (13.2% vs. 8.9%, p=0.02), and probable asthma (39.5% vs. 25.5%, p=0.0001) were significantly more frequent in the group with high HAD total scores than in the group with low HAD total scores but definite asthma was not (6.2% vs. 4.6%, p=0.2). In women: Chronic cough (34.8% vs. 23.5% p=0.009), chronic phlegm (23.9% vs. 15.4%, p=0.02), and probable asthma (53.5% vs. 35.3%, p=0.0001) were significantly more frequent in the group with high HAD total scores than in the group with low HAD total scores but definite asthma was not (7.0% vs. 9.0%, p=0.4). Conclusion: Psychological status might affect the frequency of symptom reporting in respiratory questionnaires. The questionnaires and psychological status indices should be interpreted simultaneously.
Effects of long-term low-level solvent exposure on cognitive function
(Canadian Soc Clinical Investigation, 2012) Saygun, Meral; Ekici, Aydanur; Muluk, Nuray Bayar; Cakmak, Aytul; Pinar, Tevfik; Dag, Ersel; Ekici, Mehmet
Purpose: The effects of long-term low-level exposures to solvents on cognitive function were investigated. Methods: A total of 389 workers at a gun factory, those exposed to solvents (n = 193) and those that were not exposed to solvents during work (n = 196), were included. All the workers were given a questionnaire. Cognitive function was evaluated by Mini-mental Status Examination (MMSE) and psychological status was assessed by Hospital Anxiety and Depression (HAD) Scale. Results: No differences were found in the MMSE and HAD scores between solvent-exposed workers and control workers (p>0.05). In the workers who had used a mask for a longer time, orientation scores were lower. Daytime sleepiness was related to lower recall scores.. Left-handed workers had higher total HAD scores than right-handed workers. Conclusions: Long-term low-level exposure to solvents did not affect cognitive function in the workers, according to their MMSE scores. Duration of solvent exposure was also not related to MMSE Scores. Short sleep duration and daytime sleepiness may negatively affect cognitive function.
Effects of Timolol and Latanoprost on Respiratory and Cardiovascular Status in Elderly Patients With Glaucoma
(Mary Ann Liebert, Inc, 2009) Ergin, Ahmet; Örnek, Kemal; Güllü, Reyhan; Bulcun, Emel; Ekici, Mehmet; Ekici, Aydanur
Purpose: To investigate the respiratory and cardiovascular effects of switching therapy from topical timolol 0.5% to latanoprost 0.005% in elderly patients with glaucoma. Methods: Twenty-five patients with primary open-angle glaucoma (POAG) who were treated with topical timolol 0.5% were included in the study. The beta-blocker treatment was ended due to insufficient intraocular pressure (IOP) and systemic or local side effects. The treatment then switched to latanoprost in these patients. All recruited patients underwent a full ocular, cardiovascular, and respiratory examination including spirometry, pulse rate, and blood pressure. All measurements were made 1 day before the beta-blocker treatment was ended and 30 days after the latanoprost treatment was started. Results: Timolol treatment was associated with numerically but not statistically significant lowered pulse rates, systemic blood pressure, diastolic blood pressure, and reductions in the spirometry measurements. The change to latanoprost treatment was associated with numerical improvement in mean values of spirometric test results. There were no significant differences in changes in mean values of spirometry, pulse rate, or blood pressure. Histamine challenge test was determined to be positive in 16 of 25 patients for timolol, of whom 10 were positive for latanoprost. This was statistically significant (P < 0.05). Conclusions: Although all the results presented were statistically insignificant, switching to latanoprost treatment may offer some advantages in respiratory and cardiovascular function for elderly people with glaucoma over beta-blocker drugs. Spirometry and the measurement of pulse rate and blood pressure are advised in all patients receiving topical beta-blocker therapy.
Efor dispnesinin nadir nedeni: Swyer James (mc leod) sendromu
(2009) Şentürk, Erol; Ekici, Aydanur; Bulgun, Emel; Ekici, Mehmet; Karakoç, Tülay; Tireli, Gökhan; Altınkaya, Volkan
Swyer James ya da Mc Leod Sendromu; unilateral hiperlüsen akciğer, hacim kaybı, mediastinal şift ve etkilenen tarafta daha küçük hiler gölge izlenmesi ile karakterize nadir bir hastalıktır. Pulmoner emboli, perfüzyon bozukluğu yapan diğer hastalıklar ve efor dispnesi yapan bazı hava yolu hastalıkları ile karışabilir. Bir kaç yıldır başka merkezlerde astım tanısı ile takip edilen 41 yaşında kadın olgu Swyer James Sendromu tanısı ile literatür bilgileri eşliğinde tartışıldı.
Emotional effects of nasal packing measured by the hospital anxiety and depression scale in patients following nasal surgery
(B C Decker Inc, 2005) Muluk, Nuray Bayar; Oğuztürk, Ömer; Ekici, Aydanur; Koç, Can
The aim of this study was to test the validity of the Hospital Anxiety and Depression (HAD) Scale in patients who underwent nasal surgery as a method of screening for emotional disorders during their hospital stay. The study group consisted of 50 adult patients (29 male, 21 female) who underwent nasal surgery for different reasons, such as chronic sinusitis, nasal polyposis, and nasal septal deviation. Functional endoscopic sinus surgery and/or septoplasty were managed in these patients, and all of the patients had nasal packing applied bilaterally for 2 days. The HAD Scale was given to all of the patients 1 day before surgery and 1 day after surgery, with anterior nasal packing bilaterally during the hospital stay. The anxiety and depression levels of the male group were under the cutoff points. For the female group, the depression levels were under the cutoff points, and the anxiety levels were high in the preoperative period and decreased after the operation. Anxiety and depression levels in the pre- and postoperative periods for the male and female groups were analyzed by Paired t-test. No statistically significant result was found (p >.05). It was concluded that, for patients well informed about nasal packing and hospital conditions, nasal packing may be used safely, without any psychological disturbance. The HAD Scale should be a more useful screening method to diagnose emotional disorders, especially in patients who are hospitalized for a long time.
Evaluation and impact of chronic cough: comparison of specific vs generic quality-of-life questionnaires
(Elsevier Science Inc, 2005) Kalpaklıoğlu, Ayşe Füsun; Kara, Türkan; Kurtipek, Ercan; Koçyiğit, Pınar; Ekici, Aydanur; Ekici, Mehmet
Background: Chronic cough is a common condition that has a significant impact on health-related quality of life (HRQoL). Objective: To investigate whether chronic cough is associated with adverse psychological and physical effects on quality of life (QoL) using different HRQoL questionnaires. Methods: Forty patients were recruited for the study. The diagnostic workup was mainly based on the pathogenic triad in chronic cough: postnasal drip syndrome, asthma, and gastroesophageal reflux disease. The HRQoL was evaluated with the cough-specific quality-of-life questionnaire (CQLQ), Leicester Cough Questionnaire (LCQ), Medical Outcomes Study 36-Item Short-Form Health Survey (SF-36), and Hospital Anxiety and Depression Scale. Results: Symptom scores were significantly correlated with the CQLQ and LCQ (beta =.415 and beta = -.272, respectively) but not with the SF-36. A statistically significant difference was found in all questionnaires, except the physical component summary domain of the SF-36, after specific therapy. Correlation between the 2 specific HRQoL questionnaires was moderate to high when pretreatment and posttreatment scores were compared (r = -0.42 and r = -0.60). Concurrent validity of the LCQ was higher than the CQLQ when compared with the SF-36 domains. The effect size of each specific QoL questionnaire was I or higher after treatment, whereas it was much less in the SF-36. There was no change in depression with treatment despite anxiety. Posttreatment symptom scores were related with anxiety (r > 0.40) Conclusions: Because HRQoL is important to patients, a cough-specific HRQoL instrument, either the CQLQ or LCQ, should be routinely used to optimally evaluate the impact of cough on patients and to evaluate the efficacy of cough-modifying agents. Ann Allergy Asthma Immunol. 2005;94:581-585.
Factors Associated With Quality of Life in Subjects With Stable COPD
(Daedalus Enterprises Inc, 2015) Ekici, Aydanur; Bulçun, Emel; Karakoç, Tülay; Şentürk, Erol; Ekici, Mehmet
BACKGROUND: The purpose of this study was to assess the impact of bronchiectasis, anxiety and depression, and parameters of disease severity on health-related quality of life (HRQOL) in subjects with COPD. METHODS: Sixty-two subjects with stable COPD were selected for the study. The presence of bronchiectasis in all subjects with COPD was investigated by high-resolution computed tomography. Pulmonary function tests were performed. Dyspnea was assessed using the Modified Medical Research Council (MMRC) dyspnea scale. Psychological disorders were investigated using the Hospital Anxiety and Depression Scale (HADS), and the HRQOL was examined using the St George Respiratory Questionnaire (SGRQ). RESULTS: High-resolution computed tomography revealed that 44 of 62 (70.9%) subjects with COPD had bronchiectasis. There were no differences in pulmonary function tests, symptoms, activities, impact, SGRQ total scores, and HADS scores between COPD subjects with and without bronchiectasis. Pearson correlation analyses showed that there was no significant association between the presence of bronchiectasis, bronchial wall thickness, or severity of bronchial dilatation and all subscales of the SGRQ or HADS scores. Additionally, HADS scores showed significant positive association with all subscales of the SGRQ in all subjects. In linear regression analysis, a statistically significant relationship was found between the SGRQ total score and percent-of-predicted FEV1, percent-of-predicted diffusing capacity of the lung for carbon monoxide, MMRC score, and anxiety score, but the SGRQ total score was not associated with age, body mass index, total number of hospitalizations, P-aO2, or depression score. CONCLUSIONS: The presence of bronchiectasis in subjects with COPD does not impact HRQOL and psychological disorders. However, disease severity, dyspnea levels, and anxiety scores predict poor HRQOL.
Factors Influencing Cognitive Function in Subjects With COPD
(Daedalus Enterprises Inc, 2016) Dag, Ersel; Bulcun, Emel; Turkel, Yakup; Ekici, Aydanur; Ekici, Mehmet
BACKGROUND: The aim of this study was to assess the association between cognitive function and age, pulmonary function, comorbidity index, and the 6-min walk distance in subjects with COPD as well as to compare the Mini Mental State Examination (MMSE) and Montreal Cognitive Assessment (MoCA) in terms of their ability to identify cognitive dysfunction in subjects with COPD. METHODS: A total of 52 individuals with stable COPD were included in this study. Cognitive function was assessed using MMSE and MoCA. Age, body mass index, the Modified Cumulative Illness Rating Scale, 6-min walk distance, arterial blood gases, and pulmonary function tests were assessed and recorded. RESULTS: The range and SD of scores in subjects with COPD were larger with MoCA than with MMSE. MMSE and MoCA scores are associated with 6-min walk distance and comorbidity index in subjects with COPD. General cognitive function measured by MoCA was negatively correlated with the comorbidity index but was positively associated with 6-min walk distance in subjects with COPD after controlling for possible confounding factors in the multivariate model. However, general cognitive function measured by MMSE was not correlated with the comorbidity index and 6-min walk distance in subjects with COPD, after controlling for possible confounding factors in the multivariate model. CONCLUSIONS: MoCA may be a more reliable screening test than MMSE in detecting cognitive impairment in subjects with COPD. The addition of cognitive tests on assessment of subjects with COPD can provide further benefit.

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