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    Giant condyloma acuminata of Buschke-Lowenstein: successful treatment with a combination of surgical excision, oral acitretin and topical imiquimod
    (Wiley-Blackwell Publishing, Inc, 2009) Erkek, Emel; Başar, Halil; Bozdoğan, Önder; Emeksiz, M. Can
    Human papillomavirus (HPV) is the most common sexually transmitted disorder in young, sexually active populations in the USA and Europe. Giant condyloma acuminatum (GCA) is a unique variant of condyloma acuminata, characterized by local aggressive behaviour despite benign histology. It carries a substantial risk of squamous cell carcinoma. Various treatments have been used, but response is often poor and recurrence rates high. We present a case of GCA successfully treated with a combination of surgical excision, oral acitretin and topical imiquimod. The diagnosis was based on histological examination, immunohistochemical analysis and in situ hybridization for HPV 6 and 11. We recommend a trial of oral retinoid and topical imiquimod in selected cases of GCA.
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    ISOTRETINOIN INTOXICATION IN ATTEMPTED SUICIDE: A CASE REPORT
    (Marmara Univ, Fac Medicine, 2008) Deniz, Turgut; Emeksiz, M. Can
    We report a case of acute intoxication due to a massive overdose of isotretinoin. A 17 year-old male patient had ingested 16 capsules of isotretinoin (20 mg) with suicidal intentions. He presented with nausea, dizziness and myalgia on extremities. 2 hours after the attempt he was brought to our clinic. We administered gastric lavage and active charcoal treatment before taking him to the intensive care unit for observation. 24 hours later, cutaneous xerosis and desquamation of the face especially the nasolabial region occurred; cutaneous xerosis resolved spontaneously. The side-effects were only mild exacerbations of some common isotretinoin side-effects. There was a low toxicity of isotretinoin overdose. To date, few cases of isotretinoin overdosages have been reported. Being alert when using isotretinoin on a teenager may save life because this drug may exacerbate depression as a side effect.