Yazar "Erdemoglu, Ali Kemal" seçeneğine göre listele

Listeleniyor 1 - 6 / 6
  • Küçük Resim
    Öğe
    Desensitization in Interferon-beta 1a Allergy: A Case Report
    (Karger, 2009) Kalpaklioglu, Ayse Fusun; Kavut, Ayse Baccioglu; Erdemoglu, Ali Kemal
    We report a 41-year-old patient with multiple sclerosis (MS) who was successfully desensitized after she developed non-injection-site urticaria and angioedema due to interferon (IFN)-beta 1a. Although a few cases of urticaria and anaphylaxis have been reported in the literature, to our knowledge this is the first report of a successful desensitization with IFN-beta 1a. Desensitization with IFN-beta 1a allowed us to continue with the administration of interferon-beta, which is a mainstay in treatment for MS. Copyright (C) 2009 S. Karger AG, Basel
  • [ X ]
    Öğe
    Evaluation of Changes in Cerebral Structures in Migraine Patients with Diffusion and Perfusion MRI
    (Turkish Neurological Soc, 2013) Erdemoglu, Ali Kemal; Ocaklilar, Ebru Kocacikli; Yilmaz, Sevda
    Objective: The purpose of this study is to determine ischemic lesions throughout the brain parenchyma in patients diagnosed with migraine with magnetic resonance (MR) diffusion technique, evaluate vascular architecture and possible abnormalities with MR perfusion technique and to compare these values with healthy individuals within a similar age group. Material and Method: A total of 45 migraine patients in interictal period (19 patients were diagnosed with migraine with aura) with ages between 19 and 70 (mean age 37.89 +/- 12.138) and 21 healthy volunteers with ages between 24 and 62 (mean age 36.95 +/- 13.77) were included in the study. Conventional MRI, diffusion and perfusion MRI scans were obtained. Results: Hyperintense ischemic foci were found in 35.6% of the patients. These lesions were scattered throughout the whole brain parenchyma, with more intensity at corona radiata and the frontal lobe. No pathologic findings were found in diffusion- weighted images and there were no significant differences in ADC values between the patients and the control group (p> 0.05). MR perfusion studies in migraineurs demonstrated a decrease in Cerebral Blood Flow (rCBF), prolonged Mean Transit Time (MTT) and Time to Peak (TTP) at occipital cortex, prolonged TTP at occipital white matter, centrum semiovale, cerebellum, bilateral pons, bitemporal white matter and thalamus, decreased rCBF and prolonged MTT at bilateral corona radiata, prolonged MTT at right frontal white matter, prolonged MTT and decreased rCBF and Cerebral Blood Volume (rCBV) at cerebellar cortex. Discussion: In migraine patients, changes in cerebral vascular structures that occur as a consequence of physiopathological events during interictal periods can be evaluated with MR perfusion and MR diffusion. Further studies comparing both ictal and interictal periods are required to confirm these findings.
  • Küçük Resim
    Öğe
    The long-term efficacy and safety of botulinum toxin in refractory chronic tension-type headache
    (2007) Erdemoglu, Ali Kemal; Varlibaş, Ayhan
    The objective of this study was to investigate the long-term efficacy and safety of botulinum toxin type-A (BoNT-A) for refractory chronic tension-type headache (CTTH). An open-label, prospective study was carried out in the Department of Neurology of Kirikkale University on 28 patients (8 males, 20 females), mean age 35.6 years, diagnosed with moderate/severe CTTH refractory to preventive medications. Each patient received BoNT-A injections once in pericranial muscles. Efficacy and safety data were analysed for 28 refractory CTTH patients who were receiving concomitant headache prophylactic medications at baseline and during the study. The main outcome parameters were reduction of headache frequency and intensity over 1 year. Both parameters were significantly decreased (p<0.05) by the end of the study. Sixty-four percent of patients reported complete headache relief at the final visit, compared to 7% CTTH persisted. BoNT-A also resulted in significant reductions in analgesic consumption (p<0.05). Adverse effects were transient and local. BoNT-A was found to be an effective and safe treatment for refractory CTTH patients with concomitant headache prophylactic medications, resulting in significant reductions in headache frequency, intensity and analgesic consumption which persisted up to 1 year. © Springer-Verlag Italia 2007.
  • Küçük Resim
    Öğe
    Oxidative and nitrosative stress in patients with ischemic stroke
    (Walter De Gruyter Gmbh, 2018) Dogan, Ozlem; Kisa, Ucler; Erdemoglu, Ali Kemal; Kacmaz, Murat; Caglayan, Osman; Kurku, Huseyin
    Background: Oxidative and nitrosative stress is well believed to play a role in the pathogenesis of ischemic stroke. This study aims to evaluate the time course of oxidative and nitrosative stress in ischemic stroke. Methods: In total, 27 healthy individuals, 22 individuals with high risk of ischemic stroke due to hypertension and diabetes mellitus, and 20 patients with acute ischemic stroke hospitalized at the Neurology Department of the Kirikkale University School of Medicine were enrolled in the study. Venous blood was collected at admission (hour 0) and again at hours 24, 48, 72, and 96. Nitric oxide (NO), malondialdehyde (MDA), total oxidative stress (TOS), oxidative stress index (OSI), and total antioxidant status (TAS) were measured and compared among stroke patients and control groups. Results: Blood NO was significantly higher in the patient group at 0, 24, 48, and 72 h compared to the healthy and high-risk control groups, and lower at 96 h than at early times within the patient group (p<0.001). MDA was higher in patients than the healthy control group at all times. Conversely, TOS and OSI were significantly lower in the patient group than the healthy control group at 96 h and the high-risk control group at 72 and 96 h (p <0.05). There was a significant correlation between initial NO (0 h) and duration of hospitalization (r= 0.71; p= 0.0003). Conclusions: These findings suggest a substantial early increase in oxidative and nitrosative stress in ischemic stroke patients during the first 2 days post-admission. However, TOS was lower by days 3-4, likely due to pathological recovery and local/systemic defense systems. The correlation between elevated serum NO during the acute phase of stroke and duration of hospitalization suggests NO as a potentially valuable predictor of ensuing oxidative damage and clinical outcome.
  • [ X ]
    Öğe
    Status Epilepticus in a Patient with Amyotrophic Lateral Sclerosis
    (Aves, 2014) Dag, Ersel; Sahin, Oruc; Gokce, Burcu; Erdemoglu, Ali Kemal
    Introduction: Amyotrophic Lateral Sclerosis, the most common and well-known form of motor neuron disease, is characterized by progressive degeneration of upper and lower motor neurons. Respiratory failure and aspiration due to respiratory muscle weakness is the most common causes of mortality in patients with amyotrophic lateral sclerosis. Status epilepticus is the second most frequent neurological emergency with a risk of major morbidity or mortality. Status epilepticus, due to causes such as prolonged seizures, respiratory distress, acidosis, hypoglycemia, and hypotension may lead to mortality. Case Report: A forty-eight year old male patient had been followed for 4 years with a diagnosis of amyotrophic lateral sclerosis and was referred to our clinic with the diagnosis of status epilepticus. The refractory status epilepticus patient was treated with a diagnosis of respiratory failure and the need for mechanical ventilation evolved. Conclusion: We report the development of status epilepticus in a patient with amyotrophic lateral sclerosis, and in addition to the appropriate anti-epileptic medication, ventilator support and intensive care was needed, emphasizing the life-saving procedure.
  • Küçük Resim
    Öğe
    Topiramate Induced Excessive Sialorrhea
    (Derman Medical Publ, 2015) Dag, Ersel; Habipoglu, Yasin; Erdemoglu, Ali Kemal
    It is well-known that drugs such as clozapine and lithium can cause sialorrhea. On the other hand, topiramate has not been reported to induce sialorrhea. We report a case of a patient aged 26 who was given antiepileptic and antipsychotic drugs due to severe mental retardation and intractable epilepsy and developed excessive sialorrhea complaint after the addition of topiramate for the control of seizures. His complaints continued for 1,5 years and ended after giving up topiramate. We presented this case since it was a rare sialorrhea case induced by topiramate. Clinicians should be aware of the possibility of sialorrhea development which causes serious hygiene and social problems when they want to give topiramate to the patients using multiple drugs.