Evaluation of Changes in Cerebral Structures in Migraine Patients with Diffusion and Perfusion MRI
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Tarih
2013
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Turkish Neurological Soc
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Objective: The purpose of this study is to determine ischemic lesions throughout the brain parenchyma in patients diagnosed with migraine with magnetic resonance (MR) diffusion technique, evaluate vascular architecture and possible abnormalities with MR perfusion technique and to compare these values with healthy individuals within a similar age group. Material and Method: A total of 45 migraine patients in interictal period (19 patients were diagnosed with migraine with aura) with ages between 19 and 70 (mean age 37.89 +/- 12.138) and 21 healthy volunteers with ages between 24 and 62 (mean age 36.95 +/- 13.77) were included in the study. Conventional MRI, diffusion and perfusion MRI scans were obtained. Results: Hyperintense ischemic foci were found in 35.6% of the patients. These lesions were scattered throughout the whole brain parenchyma, with more intensity at corona radiata and the frontal lobe. No pathologic findings were found in diffusion- weighted images and there were no significant differences in ADC values between the patients and the control group (p> 0.05). MR perfusion studies in migraineurs demonstrated a decrease in Cerebral Blood Flow (rCBF), prolonged Mean Transit Time (MTT) and Time to Peak (TTP) at occipital cortex, prolonged TTP at occipital white matter, centrum semiovale, cerebellum, bilateral pons, bitemporal white matter and thalamus, decreased rCBF and prolonged MTT at bilateral corona radiata, prolonged MTT at right frontal white matter, prolonged MTT and decreased rCBF and Cerebral Blood Volume (rCBV) at cerebellar cortex. Discussion: In migraine patients, changes in cerebral vascular structures that occur as a consequence of physiopathological events during interictal periods can be evaluated with MR perfusion and MR diffusion. Further studies comparing both ictal and interictal periods are required to confirm these findings.
Açıklama
Anahtar Kelimeler
Migraine; magnetic resonance imaging; diffusion; perfusion
Kaynak
Turkish Journal of Neurology
WoS Q Değeri
N/A
Scopus Q Değeri
Cilt
19
Sayı
2
