Evaluation of Changes in Cerebral Structures in Migraine Patients with Diffusion and Perfusion MRI

Basit Öğe Kaydı
dc.contributor.authorErdemoglu, Ali Kemal
dc.contributor.authorOcaklilar, Ebru Kocacikli
dc.contributor.authorYilmaz, Sevda
dc.date.accessioned2025-01-21T16:40:37Z
dc.date.available2025-01-21T16:40:37Z
dc.date.issued2013
dc.departmentKırıkkale Üniversitesi
dc.description.abstractObjective: The purpose of this study is to determine ischemic lesions throughout the brain parenchyma in patients diagnosed with migraine with magnetic resonance (MR) diffusion technique, evaluate vascular architecture and possible abnormalities with MR perfusion technique and to compare these values with healthy individuals within a similar age group. Material and Method: A total of 45 migraine patients in interictal period (19 patients were diagnosed with migraine with aura) with ages between 19 and 70 (mean age 37.89 +/- 12.138) and 21 healthy volunteers with ages between 24 and 62 (mean age 36.95 +/- 13.77) were included in the study. Conventional MRI, diffusion and perfusion MRI scans were obtained. Results: Hyperintense ischemic foci were found in 35.6% of the patients. These lesions were scattered throughout the whole brain parenchyma, with more intensity at corona radiata and the frontal lobe. No pathologic findings were found in diffusion- weighted images and there were no significant differences in ADC values between the patients and the control group (p> 0.05). MR perfusion studies in migraineurs demonstrated a decrease in Cerebral Blood Flow (rCBF), prolonged Mean Transit Time (MTT) and Time to Peak (TTP) at occipital cortex, prolonged TTP at occipital white matter, centrum semiovale, cerebellum, bilateral pons, bitemporal white matter and thalamus, decreased rCBF and prolonged MTT at bilateral corona radiata, prolonged MTT at right frontal white matter, prolonged MTT and decreased rCBF and Cerebral Blood Volume (rCBV) at cerebellar cortex. Discussion: In migraine patients, changes in cerebral vascular structures that occur as a consequence of physiopathological events during interictal periods can be evaluated with MR perfusion and MR diffusion. Further studies comparing both ictal and interictal periods are required to confirm these findings.
dc.identifier.doi10.4274/Tnd.01488
dc.identifier.endpage51
dc.identifier.issn1301-062X
dc.identifier.issn1309-2545
dc.identifier.issue2
dc.identifier.startpage44
dc.identifier.urihttps://doi.org/10.4274/Tnd.01488
dc.identifier.urihttps://hdl.handle.net/20.500.12587/24721
dc.identifier.volume19
dc.identifier.wosWOS:000217535800002
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.language.isoen
dc.publisherTurkish Neurological Soc
dc.relation.ispartofTurkish Journal of Neurology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241229
dc.subjectMigraine; magnetic resonance imaging; diffusion; perfusion
dc.titleEvaluation of Changes in Cerebral Structures in Migraine Patients with Diffusion and Perfusion MRI
dc.typeArticle

Dosyalar

Koleksiyon

WOS İndeksli Yayınlar Koleksiyonu