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Öğe Attention deficit and hyperactivity symptoms in adult migraine patients(2019) Alpua, Murat; Say, Bahar; Yavuz, Esra Turgut; Ergün, Ufuk; Buturak, Şadiye VisalAim: To screen the symptoms of attention deficit and hyperactivity disorder in adult migraine patients.Material and Methods: Our study included 102 migraine patients and 93 sex- and age-matched healthy volunteers. Gender, age, levelof education and duration of disease were recorded. We used the adult attention deficit/hyperactivity disorder self-report scale toevaluate the symptoms of adult attention deficit / hyperactivity disorder. In addition, the short form-36 and the hospital anxiety anddepression scale were applied to the patients and the healthy controls.Results: The mean scores of attention deficit hyperactivity disorder were significantly higher in migraine patients compared to thecontrol group. There was no significant relationship between the Adult Attention Deficit and Hyperactivity Disorder Self-Report Scalescores and the duration of the disease. There was a negative correlation between the SF-36 health questionnaire scores and theAdult Attention Deficit and Hyperactivity Disorder Self-Report Scale scores. There was a positive correlation between the MigraineDisability Assessment scores, the number of migraine attacks and the Adult Attention Deficit and Hyperactivity Disorder Self-ReportScale scores.Conclusion: Attention-deficit and hyperactivity symptoms can develop in adult migraine patients and cause psychosocial morbidityand poor quality of life.Öğe Case with atrophy and proximal muscle weakness: seronegative Lambert Eaton Myasthenic Syndrome(Pamukkale University, 2019) Say, Bahar; Ergün, Ufuk; Karaca, GültenLambert Eaton Myasthenic Syndrome (LEMS) is a rare neuromuscular junction disease characterized by proximal muscle weakness, decrease or loss of reflexes, moderate ocular and autonomic findings with antibody development to presynaptic voltage-dependent calcium channels. It can be paraneoplastic or autoimmun. Paraneoplastic LEMS is most commonly associated with small-cell lung cancer. Primary autoimmune may be associated with diabetes, rheumatoid arthritis, systemic lupus erythematosus, autoimmune thyroid diseases. Diagnosis is based clinical findings and electrophsyologic studies include repetetif nerve stimulation or single fiber electromyelography. Treatment includes 3,4 diaminopyridine, intravenous immunglobulin, plasmapheresis, prednisolone and azothiopurine according to the case. © 2019, Pamukkale University. All rights reserved.Öğe Cold effect in median nerve conductions in clinical carpal tunnel syndrome with normal nerve conduction studies(Elsevier Sci Ltd, 2019) Say, Bahar; Ergün, Ufuk; Turgal, Ebru; Yardımcı, İlknurClinical diagnosis of carpal tunnel syndrome (CTS) is confirmed by nerve conduction studies (NCS). In some cases, NCS may be normal. We aimed to demonstrate changes of distal motor latency (DML) and nerve conduction velocity (NCV) pathology of demyelination in entrapment neuropathy with cold application in case of clinical CTS with normal NCS. This prospective, cross-sectional, randomise, case-control involved 15 patients (25 hands) with clinically definite unilateral or bilateral CTS and normal nerve conduction studies (NCS), and 11 controls (22 hands). Ice pack was applied to median nerve trasse at wirst with monitoring skin temperature. NCS of median nerve were examinated again. Increases of DML, decrease of velocity of median nerve were observed in two groups after post-cooling. The change in NCV was greater than the change in DML. Cold effect was evident in DML and NCV in the patient group. This could be sign of the demyelination pathology. We think that cold application is influential to determine electrophysiologic abnormalities in clinic CTS with normal NCS. (C) 2018 Elsevier Ltd. All rights reserved.Öğe Detecting pain severity with full cup test in painful diabetic peripheral neuropathy(2020) Say, Bahar; Ergün, Ufuk; Yıldız, Ayşe; Alpua, Murat; Arıkan, Şenay Durmaz; Turgal, EbruObjectives: The aim of this study was to test the utility and validity of the full cup test (FCT) to assess the severity of pain in subjects with painful diabetic peripheral neuropathy (PDPN). Methods: Subjects with diabetic PDPN were enrolled for this prospective, cross-sectional study. Other causes of PDPN and subjects with cognitive impairment were excluded. The diagnosis of neuropathic pain was made using the results of a physical examination and the Douleur Neuropathique 4 questionnaire. Pain severity was assessed with a FCT and a visual analog scale (VAS) administered before and after treatment. The correlation of FCT with VAS was evaluated to examine validity. Results: A total of 43 (33 female, 10 male) subjects were included. The mean age was 61.9±8.25 years and the mean disease duration was 13.02±7.6 years. Type I diabetes mellitus (DM) was present in 2 (4.7%) subjects and Type II DM in 41 (95.3%) subjects. The mean glycated hemoglobin level was 8.9±1.9 mmol/mol. When the mean VAS and FCT scores were analyzed, the results were 6.7±2.05 and 66.35±23.2, respectively, pretreatment and 4.6±2.2 and 41.36±23.5 posttreatment, which were both statistically significant (p<0.001, p<0.001). The mean control period was 23.4 days (min–max: 15-30 days). The VAS and FCT scores in pretreatment and posttreatment demonstrated a high positive correlation (rs =0.86, p<0.001; rs =0.843, p<0.001). Conclusion: The FCT can be useful to detect pain severity in PDPN.Öğe Emotion dysregulation in migraine patients: can it be a hallmark the probability of the transformation from episodİc to chronic?(Taylor and Francis Ltd., 2023) Kocakaya, Hanife; Say, Bahar; Yörübulut, Serap; Ergün, UfukObjective: The main aim of this study was to examine patients with migraine in terms of emotional dysregulation and to evaluate whether the emotion dysregulation is effective on chronicity in migraine. Materials and Methods: A total of 85 migraine patients and 61 healthy participants were included in this study. All participants were evaluated using Migraine Disability Scale (MIDAS), Visual Analog Scale (VAS), Depression, Anxiety, and Stress Scale (DASS-21), Difficulties in Emotion Regulation Scale (DERS), Pain Catastrophizing Scale (PCS), and the Discomfort Intolerance Scale (DIS). Then, all results were compared between the migraine patients and healthy individuals. In addition, the migraine patients were separated into three groups as patients without an aura, patients with an aura and patients with chronic migraine and then their results were compared among them. Finally, the predictive markers of chronic migraine were explored using regression analyses. Results: Among 85 migraine patients, the mean age was 31.5 (SD = 7.98); 83.5% were women. The total and subscale scores of DERS, PCS, DIS, and DASS-21 were significantly higher in patients than in healthy individuals (p < 0.01). Subscale scores of DERS, DIS, and DASS-21 in the chronic migraine patients were found to be higher than in the other two patient groups (p < 0.01). Logistic regression analysis showed that chronic migraine could be associated with ‘lack of emotional clarity’ (OR = 1.229; p = 0.042), ‘lack of awareness’ (OR = 1.187; p = 0.032), ‘migraine associated disability’ (OR = 1.128; p = 0.033), and ‘stress’ (OR = 1.292; p = 0.027). Conclusion: This study results showed that chronic migraine could be associated with the emotional dysregulation. To our knowledge, this study is the preliminary study in the literature and, therefore, new studies with large samples are needed. © 2023 Informa UK Limited, trading as Taylor & Francis Group.Öğe Evaluation of putamen area and cerebral peduncle with surrounding cistern in patients with Parkinson’s disease: is there a difference from controls in cranial MRI?(Taylor and Francis Ltd., 2024) Say, Bahar; Bayar Muluk, Nuray; İnal, Mikail; Göncüoğlu, Alper; Yörübulut, Serap; Ergün, UfukObjectives: Nigrostriatal dopaminergic neuron loss is essential in pathogenesis of Parkinson’s disease (PD). The purpose of this study was to evaluate nigrostriatal structures including the putamen, cerebral peduncle, widths of interpeduncular cistern, and ambient cistern around the midbrain with conventional cranial magnetic resonance images (MRI) in patients with PD. Methods: The MRI of 56 subjects was included, which was selected from the radiological data system for this retrospective study. The 29 patients with idiopathic PD were included and their disease duration, Hoehn&Yahr stage, and Levodopa equivalent dose (LED) were recorded. The 27 controls had a normal neurologic examination and cranial MRI. All subjects in the patient and control groups had right-hand dominance. Putamen and cerebral peduncle areas and widths of interpeduncular and ambient cisterns were measured in T2 sequences of MRI. Further statistical analysis was applied to exclude gender and age effect on areas. Results: The areas of putamen and cerebral peduncles were significantly reduced in patients with PD compared to the control bilaterally (p < 0.001). Enlargement of interpeduncular and ambient cisterns in patients was higher than in controls, and it was significant (p < 0.001). A correlation was not observed between measurement results and clinical characteristics of patients with PD. Only the cerebral peduncle area/ambient cistern width ratio was significantly correlated with disease duration positively (right r = 0.46 p = 0.012, left r = 0.389 p = 0.037). Conclusion: Clinicians should be careful with conventional MRIs of patients with idiopathic PD in practice. It may be different from controls without any neurological disorder, particularly putamen, cerebral peduncles, interpeduncular, and ambient cisterns. © 2023 Informa UK Limited, trading as Taylor & Francis Group.Öğe HALLUCINATION AND RISK FACTORS IN PATIENTS WITH PARKINSON’S DISEASE(2019) Say, Bahar; Ünal, Yasemin; Tunç, Tuğba; Ergun, Ufuk; Ergün, UfukObjective: Hallucination is one of the non-motor symptoms inParkinson disease (PD). Several factors may affect the presenceof hallucination. In the present study, we aimed to compare PDpatients presenting with and without hallucinations, to determinerisk factors, and to find out common hallucination types.Material and Methods: Idiopathic Parkinson patients regardingto UK Parkinson Disease Society Brain Bank with and withouthallucinations were compared. The patients with psychoticsymptoms due to metabolic, infectious, and structural causeswere excluded. Disease severity was evaluated by UnifiedParkinson Disease Rating Scale and Hoehn and Yahr staging.Cognitive status was assessed by Minimental State Examinationtest. Depression was diagnosed on the basis of DSM-V Tr.Description of hallucination, treatment, co-morbidity, sleepdisturbances, REM sleep behavioral disorder, age, gender,scores of test and scale, stage of disease were recorded.Results: A total of 91 (59 female, 32 male) patients withidiopathic PD were enrolled. The group with hallucinations(Group 1) had 40 (43.9%) patients and the one withouthallucinations (Group 2) had 51 (54.9%) patients. Total score ofUnified Parkinson Disease Rating Scale was significantly higherin Group 1 than Group 2 (37.83±16.65; 30.18±14.83; p=0.028).Sleep disturbances were high in Group 1 (n=24, 60%) whencompared to Group 2 (n=14, 27.4%) (p=0.007). The meanduration of hallucinations was 24.87±56.47 months in Group 1.Twenty-one patients (23.9%) had visual hallucinations; 15(16.5%) patients had illusions (minor hallucinations); and four(4.4%) patients had auditory hallucinations.Conclusion: Disease severity in Parkinson's disease may be afactor in the presence of hallucinations. Hallucinations may alsooccur with sleep disorders. Minor hallucinations are frequentlyobserved in early stages, with visual hallucinations being themost common hallucinations that may occur in every diseasestage.Öğe Investigation of food preference in Alzheimer patients; Assessment of glycemic index and glycemic load of their diet(Ondokuz Mayis Universitesi, 2024) Yilmaz Can, Fatma; Ergün, Ufuk; İNan, Levent E.; Gök, Gökmen; Aslı, Devri?M Lampi?RIn this study, our objective was to investigate the food preferences of patients with Alzheimer’s-type dementia and healthy individuals of the same age and to compare the glycemic index and glycemic load of the preferred foods. This study was conducted with 55 patients, who were diagnosed with Alzheimer’s-type dementia by a neurologist, and 57 healthy individuals at the same age interval as the control group. The cognitive functions of the participants were assessed with the Standardized Mini-Mental State Exam (SMMSE). The food consumption preferences were determined following the obtainment of the three-day food consumption records and then the glycemic index and glycemic load of the diets was calculated. The carbohydrate amount consumed by Alzheimer's patients, the energy content of the diet, and the glycemic load were significantly higher (p<0.05) compared to the control group. The comparison of Alzheimer's patients, who were divided into two groups, mild dementia (SMMSE=18-23) and severe dementia (SMMSE?17) according to the SMMSE scores, showed that patients with severe dementia consumed significantly more carbohydrates and the energy content of their diet was higher (p<0.05). We determined that Alzheimer's patients consumed more carbohydrates and sugar compared to the control group. The daily carbohydrate intake increased as the severity of the disease increased, however, the quality of the consumed carbohydrate remained the same. © 2024 Ondokuz Mayis Universitesi. All rights reserved.Öğe OBSTRÜKTİF UYKU APNE SENDROMU VE NÖROLOJİ(2018) Hamamcı, Mehmet; Alpua, Murat; Ergün, Ufuk; İnan, Levent ErtuğrulObstrüktif Uyku Apne Sendromu (OUAS) nörolojik hastalar arasında sık görülen ciddi bir durumdur. OUAS’ın etyolojisinde, ayırıcı tanısında ve sonuçlarında nörolojik hastalıklar bulunmaktadır. OUAS’ın nörolojik hastalıklarla birlikteliği daima dikkat çekmiştir. OUAS birçok nörolojik semptomu içinde barındıran bir sendromdur. OUAS tanınmaz ve tedavi edilmezse, birçok nörolojik hastalığa sebep olabilir , potansiyel olarak birbirlerini daha da kötüleştirebilirler ve sonuçta ölüme yol açabilir. Bu derlemede, nörolojik hastalıklarla OUAS ilişkisi ele alınmıştır.Öğe Sol Hemipleji Ve Dizartri İle Başvuran Multipl Skleroz Tanılı Hastada Akut İskemik İnme(2018) Say, Bahar; Tunç, Mehmet; Yardımcı, İlknur; Alpua, Murat; Ergün, UfukMultipl Sklerozda, santral sinir sistemindeki kronik inflamasyonun indüklediği endotelial disfonksiyon ve buna bağlı ateroskleroz serebrovasküler hastalık riskini artırır. Multipl Skleroz (sekonder progressif) ve hipertansiyon (regüle) tanıları olup EDSS skoru 6 olan 54 yaşındaki bayan hasta intravenöz yüksek doz pulse steroid tedavisi sonrası sol tarafında ani güç kaybı, konuşma ve yutma bozukluğu ile getirildi. Acil servisteki difüzyon MR’da mezensefalon ile pons sağ kesiminde, serebellar hemisferlerde difüzyon kısıtlaması gösteren akut enfarkt alanları izlendi. İnme etiyolojisine yönelik yapılan karotisvertebral doopler ultrasonografi ve transtorasik ekokardiografi normaldi. Ritm holterde, aritmi izlenmedi. Rutin laboratuar tetkikleri, tromboz ve vaskülit markerlerinde patoloji saptanmadı. Olguda inme nedeni olarak Multipl Skleroz ve immobilite düşünüldü. Multipl Skleroz hastalarında yeni gelişen nörolojik disfonksiyon durumunda atak dışı neden, inme olasılığı da her zaman akılda tutulmalıdır.
