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    Effect of the coronavirus disease-2019 pandemic on the follow-up and treatment of patients with rosacea
    (Galenos Publ House, 2023) Durak, Murat; Gündüz, Özgür
    Background and Design: This study aimed to investigate the effects of the precautions and preventive measures implemented during the coronavirus disease-2019 (COVID-19) pandemic on the follow-up and treatment processes of patients with rosacea who applied to the Skin and Venereal Diseases outpatient clinic of a university hospital in Turkiye.Materials and Methods: Age, sex, number of hospital admissions, prescribed topical and systemic treatments, total amount of treatment on a box basis, follow-up interval in multiple applications, and number of applications to the Ophthalmology Department were recorded before and during the COVID-19 pandemic. Results: No difference was found in the age and sex distributions of patients with rosacea who applied to the Skin and Venereal Diseases outpatient clinic during the COVID-19 pandemic compared with that before the pandemic. However, the total number of patients decreased. Furthermore, the total number of drugs prescribed to patients and the number of systemic drugs increased proportionally during the COVID-19 pandemic. In addition, the ratio of patients who continued their follow-up and the use of systemic drugs among these patients increased.Conclusion: In this study, the number of admissions decreased and the rate of patients who needed systemic treatment increased. Rosacea and similar dermatoses that required long-term follow-up could be evaluated via teledermatology during periods when application to outpatient clinics for follow-up becomes difficult such as during pandemics and natural disasters.
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    JAK/STAT pathway modulation: Does it work in dermatology?
    (Wiley, 2019) Gündüz, Özgür
    Janus kinase-signal transducer and activator of transcription (JAK/STAT)-is an intracellular signaling pathway, which plays a key role in downstream transmission of extracellular signals from cell membrane to the cell nucleus. This pathway is activated by cytokines, which participate in inflammation, innate and acquired immune responses, and also cell growth. Recent studies point out possible disturbances in JAK/STAT pathway in various inflammatory and autoimmune skin diseases, such as atopic dermatitis, psoriasis, alopecia areata. Several molecules that modulate-inhibit-this pathway are currently under investigation for the evaluation of their clinical use in dermatological diseases. A brief overview of the therapeutical use of JAK/STAT inhibitors in dermatology will be provided here.
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    Lichen Planus Pigmentosus-Inversus: A Report of Two Cases
    (2019) Demirkan, Serkan; Gündüz, Özgür; Devrim, Tuba
    Lichen planus pigmentosus (LPP)-inversus has been identified in a few East European cases primarily intertriginous areas such as axilla and groin which is not contacting with sunlight, and involvement in other skin areas was rarely detected. Because the lesions are similar to LPP in clinical and histological appearance, this condition, which is characterized by hyperpigmented, brown macules or plaques, is called LPP-inversus. Until today, actinic LP, linear LP, zosteriform, and LP pigmentosus clinical subtypes of lichen planus have been described. LPP-inversus is a rare form of LP and so far, there have been few case reports. LPP-inversus has been reported mostly in Caucasians and Asians, and axilla was the most involved body region. In a small proportion (approximately 10%) of the cases, classical LP or LPP lesions may be located outside the flexural areas. So far, about 50 cases have been reported; also we presented two new cases that we diagnosed.