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Öğe Bullous scabies, the light shed on etiopathogenesis and treatment: report of five paediatric cases(Termedia Publishing House Ltd, 2023) Arslan, Hakan; Gündüz, ÖzgürIntroduction: Bullous scabies (BS) is an infrequent and atypical presentation of scabies, with a predilection for el- derly males. The mechanism of BS is not fully understood; superinfection, friction due to pruritus, autoeczemation, direct injury from mite's lytic enzymes, cross-reactivity of scabies protein with basal membrane zone antigens are considered to be possible reasons. Aim: To define clinical features of paediatric BS cases, which is an extremely rare subtype of scabies. Material and methods: This is a retrospective study of paediatric BS cases seen at two tertiary care centres. Previ- ously described bacterial culture, antibiogram and follow-up records were investigated retrospectively. Confirmed scabies cases, according to the International Alliance for the Control of Scabies (IACS) with bullae were included. All cases were treated with 10% sulfur ointment for 3 consecutive days, two cycles. Households of cases were also treated simultaneously. Systemic antibiotics were added to patients with elevated acute phase reactants according to the antibiogram results. Informed consent was obtained from patients' parents. Results: Five BS cases were included. Three cases were male, two cases were female. Four cases had staphylococcus aureus, one had group-A beta haemolytic streptococcus positive bullae culture. All cases achieved a rapid complete resolution of symptoms after topical 10% sulfur ointment. Conclusions: Paediatric BS is an extremely rare entity of scabies. Bacterial superinfection plays a key role in bullae formation. 10% sulfur ointment is a highly effective treatment option for paediatric BS.Öğe A different harlequin color change case(OrtadogŸu Reklam Tanitim Yayincilik Turizm Egitim Insaat Sanayi ve Ticaret A.S., 2017) Demirkan, Serkan; Gündüz, ÖzgürHarlequin colour change is a transient condition that alarms parents usually. The skin area that infant lay on is erythematous, other part is pale and there is a sharp boundary in the middle of the body. Sometimes it does not occur on face and genital area, mucous membranes. Erythema and pallor replace by changing position. It is thought that the cause of it is vasodilatation due to lack of vascular tone depending on immature hypothalamic or sympathetic system. It is also reported that this condition may develop depending on traumas preponderant to sympathetic chain, tumours and vascular pathologies. We have reported a case due to it has differences about clinical presentation between other reported cases. Copyright © 2017 by Türkiye Klinikleri.Öğe Effect of the coronavirus disease-2019 pandemic on the follow-up and treatment of patients with rosacea(Galenos Publ House, 2023) Durak, Murat; Gündüz, ÖzgürBackground and Design: This study aimed to investigate the effects of the precautions and preventive measures implemented during the coronavirus disease-2019 (COVID-19) pandemic on the follow-up and treatment processes of patients with rosacea who applied to the Skin and Venereal Diseases outpatient clinic of a university hospital in Turkiye.Materials and Methods: Age, sex, number of hospital admissions, prescribed topical and systemic treatments, total amount of treatment on a box basis, follow-up interval in multiple applications, and number of applications to the Ophthalmology Department were recorded before and during the COVID-19 pandemic. Results: No difference was found in the age and sex distributions of patients with rosacea who applied to the Skin and Venereal Diseases outpatient clinic during the COVID-19 pandemic compared with that before the pandemic. However, the total number of patients decreased. Furthermore, the total number of drugs prescribed to patients and the number of systemic drugs increased proportionally during the COVID-19 pandemic. In addition, the ratio of patients who continued their follow-up and the use of systemic drugs among these patients increased.Conclusion: In this study, the number of admissions decreased and the rate of patients who needed systemic treatment increased. Rosacea and similar dermatoses that required long-term follow-up could be evaluated via teledermatology during periods when application to outpatient clinics for follow-up becomes difficult such as during pandemics and natural disasters.Öğe Histopathological evaluation of Behçet's disease and identification of new skin lesions(2012) Gündüz, ÖzgürBehçet's disease (BD) is a multisystemic, relapsing inflammatory disorder with an obscure etiology and pathogenesis. Diagnosis depends on the clinician's ability to identify a group of nonspecific mucocutaneous lesions, which also manifest in a number of other diseases. In recent years, there has been an increase in the studies focusing on the histopathological aspects of Behçet's disease diagnostic mucocutaneous lesions. Their results emphasize the value of histopathology and direct immunofluorescence (DIF) in the differential diagnosis of Behçet's disease. © 2012 Özgür Gündüz.Öğe JAK/STAT pathway modulation: Does it work in dermatology?(Wiley, 2019) Gündüz, ÖzgürJanus kinase-signal transducer and activator of transcription (JAK/STAT)-is an intracellular signaling pathway, which plays a key role in downstream transmission of extracellular signals from cell membrane to the cell nucleus. This pathway is activated by cytokines, which participate in inflammation, innate and acquired immune responses, and also cell growth. Recent studies point out possible disturbances in JAK/STAT pathway in various inflammatory and autoimmune skin diseases, such as atopic dermatitis, psoriasis, alopecia areata. Several molecules that modulate-inhibit-this pathway are currently under investigation for the evaluation of their clinical use in dermatological diseases. A brief overview of the therapeutical use of JAK/STAT inhibitors in dermatology will be provided here.Öğe Lichen Planus Pigmentosus-Inversus: A Report of Two Cases(2019) Demirkan, Serkan; Gündüz, Özgür; Devrim, TubaLichen planus pigmentosus (LPP)-inversus has been identified in a few East European cases primarily intertriginous areas such as axilla and groin which is not contacting with sunlight, and involvement in other skin areas was rarely detected. Because the lesions are similar to LPP in clinical and histological appearance, this condition, which is characterized by hyperpigmented, brown macules or plaques, is called LPP-inversus. Until today, actinic LP, linear LP, zosteriform, and LP pigmentosus clinical subtypes of lichen planus have been described. LPP-inversus is a rare form of LP and so far, there have been few case reports. LPP-inversus has been reported mostly in Caucasians and Asians, and axilla was the most involved body region. In a small proportion (approximately 10%) of the cases, classical LP or LPP lesions may be located outside the flexural areas. So far, about 50 cases have been reported; also we presented two new cases that we diagnosed.Öğe Micronutrient Deficiencies and Digital Computerized Phototrichogram Analysis in Telogen Effluvium: a Retrospective Correlation Study in a Tertiary Medical Center(Mattioli 1885, 2023) Arslan, Hakan; Gündüz, ÖzgürIntroduction: Telogen effluvium (TE) is a common form of non-scarring alopecia that may manifest as acute or chronic hair shedding. Several studies evaluated a possible relationship between various vitamin and mineral deficiencies and TE, but it is still a controversial topic. Objectives: This study aimed to investigate the status of vitamin and mineral deficiencies in patients diagnosed with TE and to evaluate their correlation with anagen hair ratios (AHR) calculated with an automated digital phototrichogram (ADCP). Methods: Electronic records of 973 TE patients were retrospectively analyzed. Demographic, clinical data, parameters such as ferritin, vitamin B12 (Vit-B12), vitamin D (Vit-D), folic acid, zinc and hemoglobin (HGB) serum levels were evaluated. Anagen to telogen hair ratios were also assessed in forty-two patients via ADCP. Results: The rates of anemia, low ferritin level, and Vit-B12, folate, Vit-D, and zinc deficiencies were 11.9% (N = 109), 44% (N = 332), 1.5% (N = 13), 2.5% (N = 14), 87% (N = 51), and 4.5% (N = 2), respectively. A positive correlation was found between HGB levels and AHR in female patients (Spearman rank, r = 0.417, P = 0.008). No statistically significant relationship was found between ferritin, Vit-B12, folate, zinc serum levels and AHR. The relationship between Vit-D and AHR could not be assessed due to the insufficient number of patients with Vit-D data. Conclusions: HGB value is the only marker that is positively correlated with the AHR of patients with TE. Ordering HGB can be used as an initial test for managing TE patients cost-effectively.Öğe Relapsing polychondritis misdiagnosed and treated as a “soft tissue infection” and a brief review of diagnostic clinical clues(OrtadogŸu Reklam Tanitim Yayincilik Turizm Egitim Insaat Sanayi ve Ticaret A.S., 2017) Gündüz, Özgür; Demirkan, Serkan; Samav, Güzin; Arslan, Hakan; Çakartaş, RebiyeRelapsing polychondritis (RPC) is a rare immune-mediated disease, which targets particularly the cartilaginous tissue. At the initial stages of RPC, recurring mild-inflammatory attacks targeting the ears, nose, eyes, joints and respiratory tract can be observed but as the disease progresses, aortic and/or mitral valvular regurgitation (AR/MR) or life-threatening tracheobronchomalacia (due to involvement of aortic, mitral valves and/or trachea) may occur, as well as severe destruction of the ear, nose, etc. RPC may coexist with other diseases, such as systemic vasculitides, Graves disease or myelodysplastic syndrome. Establishing an early diagnosis is of utmost importance to prevent the development of AR/MR, or tracheobronchomalacia by preserving the cartilage tissue and also to diagnose a possible coexisting disease. Patients, particularly at the initial stages of the disease may object to a skin biopsy due to concerns for visible scars. Therefore, a good grasp of RPC's clinical symptoms may facilitate to establish an early diagnosis. Copyright © 2017 by Türkiye Klinikleri.
