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    The effect of sodium hypochlorite application on the success of calcium hydroxide pulpotomy in primary teeth
    (2006) Tunç, Emine Şen; Şaroğlu, Işıl; Sarı, Şaziye; Günhan, Ömer
    Objective: The aim of this study was to evaluate the effects of 3% sodium hypochlorite (NaOCl) used as a hemostatic agent on the outcome of calcium hydroxide pulpotomies of primary teeth. Study design: A total of 18 primary molars with advanced caries and root resorption of approximately half the root length were randomly placed into 2 groups. Conventional calcium hydroxide pulpotomies were performed on teeth in both groups; however, a cotton pellet saturated with 3% sodium hypochlorite was applied to teeth in the treatment group for 30 seconds before the pulpotomy to control hemorrhage. After the extraction of the teeth, they were examined histologically. Results: In the histologic evaluation it was found that none of the specimens in the control group showed necrosis and 1 specimen in the treatment group showed partial necrosis. Conclusion: It was found that the use of 3% NaOCl as a hemostatic agent had no effect on the outcome of calcium hydroxide pulpotomies with the given concentration and timing of the NaOCl treatment and the given observation period. © 2006 Mosby, Inc. All rights reserved.
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    Öğe
    Subepithelial Fibrinous Accumulation and Associated Epithelial Proliferation in Laryngeal Nodules
    (2022) Başak, Kayhan; Günhan, Ömer; Çaputcu, Merve; Arda, Şule Sağlam; Atlı, Muharrem; Demir, Derya; Oğuztüzün, Serpil
    Objective: Fibrinoid accumulation in the larynx and increase in the subepithelial collage-\rnous connective tissue result in overgrowth. Mucosal epithelium may proliferate downward\rto organize and remove the fibrinoid accumulation. This downward proliferation may cause\ran invasive cancer-like image. This study focused on the pathogenesis of the accumulation of\rfibrinoid substance and the development mechanism of the associated squamous epithelium\rproliferation.\rMethods: Five hundred and seventy-five laryngeal nodules were reexamined and 111 of\rthem with varying degrees of irregular downward squamous epithelial proliferation were\rincluded in the study. Immunohistochemical staining of CK5/6, CK17, CK14, collagen type\rI, collagen type III, collagen type IV, and fibrinogen was performed. A modified Masson’s\rtrichrome method was used for the histochemical staining of collagen.\rResults: Edema was present in 18% of the acute lesions and fibrin deposition in 42%. Rela-\rtively mature lesions mostly contain dense collagen fibers. The intensity of collagen type III\rwas inversely proportional to the amount of fibrin accumulation. Collagen type IV was found\rin the epithelial and vascular basement membranes. A decrease in fibrin staining intensity\rand the presence of collagen type I and type III indicated the replacement of fibrin with col-\rlagen. Basal-type keratins showed more pronounced staining in the regenerated areas of the\repithelium. As the laryngeal subepithelial fibrinoid accumulation was replaced with collagen,\rregression of the lesion became difficult.\rConclusion: Irregular squamous epithelial proliferation occurs independent of the stage of\rthe lesion. Although the etiology is different, the resulting lesions are histologically similar to\rthose seen in the ligneous mucosal disease