Subepithelial Fibrinous Accumulation and Associated Epithelial Proliferation in Laryngeal Nodules
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Tarih
2022
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Objective: Fibrinoid accumulation in the larynx and increase in the subepithelial collage-\rnous connective tissue result in overgrowth. Mucosal epithelium may proliferate downward\rto organize and remove the fibrinoid accumulation. This downward proliferation may cause\ran invasive cancer-like image. This study focused on the pathogenesis of the accumulation of\rfibrinoid substance and the development mechanism of the associated squamous epithelium\rproliferation.\rMethods: Five hundred and seventy-five laryngeal nodules were reexamined and 111 of\rthem with varying degrees of irregular downward squamous epithelial proliferation were\rincluded in the study. Immunohistochemical staining of CK5/6, CK17, CK14, collagen type\rI, collagen type III, collagen type IV, and fibrinogen was performed. A modified Masson’s\rtrichrome method was used for the histochemical staining of collagen.\rResults: Edema was present in 18% of the acute lesions and fibrin deposition in 42%. Rela-\rtively mature lesions mostly contain dense collagen fibers. The intensity of collagen type III\rwas inversely proportional to the amount of fibrin accumulation. Collagen type IV was found\rin the epithelial and vascular basement membranes. A decrease in fibrin staining intensity\rand the presence of collagen type I and type III indicated the replacement of fibrin with col-\rlagen. Basal-type keratins showed more pronounced staining in the regenerated areas of the\repithelium. As the laryngeal subepithelial fibrinoid accumulation was replaced with collagen,\rregression of the lesion became difficult.\rConclusion: Irregular squamous epithelial proliferation occurs independent of the stage of\rthe lesion. Although the etiology is different, the resulting lesions are histologically similar to\rthose seen in the ligneous mucosal disease
Açıklama
Anahtar Kelimeler
Kulak, Burun, Boğaz
Kaynak
Southern Clinics of Istanbul Eurasia
WoS Q Değeri
Scopus Q Değeri
Cilt
33
Sayı
2
