Subepithelial Fibrinous Accumulation and Associated Epithelial Proliferation in Laryngeal Nodules

Basit Öğe Kaydı
dc.contributor.authorBaşak, Kayhan
dc.contributor.authorGünhan, Ömer
dc.contributor.authorÇaputcu, Merve
dc.contributor.authorArda, Şule Sağlam
dc.contributor.authorAtlı, Muharrem
dc.contributor.authorDemir, Derya
dc.contributor.authorOğuztüzün, Serpil
dc.date.accessioned2025-01-21T16:18:14Z
dc.date.available2025-01-21T16:18:14Z
dc.date.issued2022
dc.departmentKırıkkale Üniversitesi
dc.description.abstractObjective: Fibrinoid accumulation in the larynx and increase in the subepithelial collage-\rnous connective tissue result in overgrowth. Mucosal epithelium may proliferate downward\rto organize and remove the fibrinoid accumulation. This downward proliferation may cause\ran invasive cancer-like image. This study focused on the pathogenesis of the accumulation of\rfibrinoid substance and the development mechanism of the associated squamous epithelium\rproliferation.\rMethods: Five hundred and seventy-five laryngeal nodules were reexamined and 111 of\rthem with varying degrees of irregular downward squamous epithelial proliferation were\rincluded in the study. Immunohistochemical staining of CK5/6, CK17, CK14, collagen type\rI, collagen type III, collagen type IV, and fibrinogen was performed. A modified Masson’s\rtrichrome method was used for the histochemical staining of collagen.\rResults: Edema was present in 18% of the acute lesions and fibrin deposition in 42%. Rela-\rtively mature lesions mostly contain dense collagen fibers. The intensity of collagen type III\rwas inversely proportional to the amount of fibrin accumulation. Collagen type IV was found\rin the epithelial and vascular basement membranes. A decrease in fibrin staining intensity\rand the presence of collagen type I and type III indicated the replacement of fibrin with col-\rlagen. Basal-type keratins showed more pronounced staining in the regenerated areas of the\repithelium. As the laryngeal subepithelial fibrinoid accumulation was replaced with collagen,\rregression of the lesion became difficult.\rConclusion: Irregular squamous epithelial proliferation occurs independent of the stage of\rthe lesion. Although the etiology is different, the resulting lesions are histologically similar to\rthose seen in the ligneous mucosal disease
dc.identifier.doi10.14744/scie.2022.47154
dc.identifier.endpage115
dc.identifier.issn2587-0998
dc.identifier.issn2587-1404
dc.identifier.issue2
dc.identifier.startpage109
dc.identifier.trdizinid535254
dc.identifier.urihttps://doi.org/10.14744/scie.2022.47154
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/535254
dc.identifier.urihttps://hdl.handle.net/20.500.12587/22826
dc.identifier.volume33
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.relation.ispartofSouthern Clinics of Istanbul Eurasia
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241229
dc.subjectKulak
dc.subjectBurun
dc.subjectBoğaz
dc.titleSubepithelial Fibrinous Accumulation and Associated Epithelial Proliferation in Laryngeal Nodules
dc.typeArticle

Dosyalar

Koleksiyon

TR-Dizin İndeksli Yayınlar Koleksiyonu