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Öğe Effect of ankaferd blood stopper in experimental peritoneal adhesion model(Korean Surgical Society, 2016) Karaca, Gokhan; Aydin, Oktay; Pehlivanli, Faruk; Kocael, Ahmet; Pekcici, Recep; Duymus, Esat; Guler, OsmanPurpose: Ankaferd Blood Stopper (ABS) is an herbal extract attained from 5 different plants. It has the therapeutic, potential to be used for the management of external hemorrhage and controlling gastrointestinal bleedings. To date, the safety of ABS for intraperitoneal usage is not clear. In this study, we investigated the effectiveness and safety of using intraperitoneal ABS in an experimental peritoneal adhesion Model. Methods: Twenty-four male Wistar Albino rats were used in the study. The rats were randomly divided into 3 groups: saline, ABS, and control. On the 10th day, all rats were euthanized. The adhesions were evaluated by Nair's macroscopic adhesion classification, and pathologically evaluated with Zuhlke's microscopic adhesion classification. Results: A macroscopic and microscopic comparison between the ABS and saline groups did not show any differences but both the ABS and saline groups were superior when compared to the control group. Conclusion: ABS was found equally effective with saline on the abdominal adhesions and to no effect on postoperative adhesion formation.Öğe Effectiveness of thymoquinone, zeolite, and platelet-rich plasma in model of corrosive oesophagitis induced in rats(Korean Surgical Society, 2017) Karaca, Gokhan; Aydin, Oktay; Pehlivanli, Faruk; Altunkaya, Canan; Uzun, Hafize; Guler, OsmanPurpose: The effectiveness of platelet-rich plasma (PRP), thymoquinone, and zeolite-in corrosive esophageal burns was investigated in a rat model. Methods: Four groups were comprised as containing 10 rats in each group. For group I, oesophagitis was induced and no other procedure was performed (control group). For group II, oesophagitis was induced and thymoquinone was administered for 1 week via oral gavage once a day (thymoquinone group). For group III, oesophagitis was induced for 1 week via oral gavage once a day (PRP group). For group IV, oesophagitis was induced and zeolite was administered for 1 week via oral gavage once a day (zeolite group). On the 10th day, the rats were sacrificed under anaesthesia and venous blood sampling was performed from the vena portae. The oesophaguses were totally excised.-Biochemically, interleukin. (IL)-1B, IL-6, TNF-alpha, and MCP-1 were examined from venous blood. Inflammation score was evaluated histopathologically in oesophageal tissue that was collected. Results: There was a statistically significant difference among groups in terms of IL-1, IL-6, MCP levels, compared to the control group; median IL-1, IL-6, MCP levels of thymoquinone, PRP, and zeolite groups were statistically significantly' lower. There was a statistically significant difference among groups in terms of inflammation scores, compared to group I; median inflammation scores of groups II, III and IV were statistically significantly lower thymoquinone. Conclusion: PRP, and zeolite exhibited positive effect on recovery in oesophagitis by reducing inflammation in the involved segment.Öğe Effectiveness of thymoquinone, zeolite, and platelet-rich plasma in model of corrosive oesophagitis induced in rats (vol 92, pg 396, 2017)(Korean Surgical Society, 2017) Karaca, Gokhan; Aydin, Oktay; Pehlivanli, Faruk; Altunkaya, Canan; Uzunl, Hafize; Guler, Osman[Abstract No tAvailable]Öğe The effects of scalpel, harmonic scalpel and monopolar electrocautery on the healing of colonic anastomosis after colonic resection(Korean Surgical Society, 2016) Karaca, Gokhan; Pekcici, M. Recep; Altunkaya, Canan; Fidanci, Vildan; Kilinc, Aytul; Ozer, Huseyin; Guler, OsmanPurpose: In our study, the effects of harmonic scalpel, scalpel, and monopolar electrocautery usage on the health and healing of colon anastomosis after resection was investigated. Methods: In this study, 120 female albino Wistar rats were divided into 3 groups each containing 40 rats. Group A, resection with scalpel; group B, resection with monopolar electrocautery; group C, resection with harmonic scalpel. The groups were divided into 4 subgroups consisting of 10 rats and analysed in the postoperative 1st, 3rd, 5th, and 7th days. Anastomotic bursting pressures, hydroxyproline levels and histopathological parameters were surrogate parameters for evaluating wound healing. Results: The tissue hydroxyproline levels did not show any significant difference between the groups and subgroups. The mean bursting pressure of group A on the 5th day was significantly higher than groups B and C (P < 0.001). When the fibroblast and fibrosis scores were evaluated, scores of group C on the 5th day were significantly higher than the other groups, but the results of bursting pressures and biochemical parameters did not support the fibroblast and fibrosis scores. There were not any significant differences between the groups in other histopathologic parameters. Conclusion: The use of monopolar electrocautery needs more attention since the device causes tissue destruction. The obliterating effect of harmonic scalpel on luminal organs is an important problem, especially if an anastomosis is planned. Despite the disadvantages of scalpel, its efficacy on early wound healing is better than the other devices.Öğe Ensemble learning based lung and colon cancer classification with pre-trained deep neural networks(Springer Heidelberg, 2024) Savas, Serkan; Guler, OsmanPurposeLung and colon cancer are among the most common cancer types with the highest mortality rates worldwide. In recent years, studies have been carried out on the early diagnosis and detection of lung cancer and colon cancer. Also, new treatment methods and options have been investigated. With the development of early diagnostic methods, the survival rate of patients has increased. Therefore, in this study, a transfer learning-based deep ensemble learning model is proposed for the classification of lung and colon cancer from histopathological images.MethodsExperiments were carried out on the LC25000 dataset with the proposed approach. DenseNet121, InceptionV3, MobileNet, ResNet50, ResNet101, VGG16, and Xception models were used for transfer learning. These models were implemented with different variations for ensemble learning.ResultsIt is seen that the most successful transfer learning model is the InceptionV3 model, and the ResNet101 model has the lowest performance. The DETL_V1 model, in which all models were used, was the most successful model with an accuracy rate of 99.78%.ConclusionBy focusing on top models and using ensemble learning to combine their predictions, better performance was obtained compared to any single model on its own. Obtaining a more robust and generalizable model was achieved by combining multiple models that are trained on different subsets of the data with different architectures. The results proved that the proposed approach is supportive for decision in clinical diagnosis processes.Öğe Platelet-Rich Plasma May Offer a New Hope in Suppressed Wound Healing When Compared to Mesenchymal Stem Cells(Mdpi, 2018) Aydin, Oktay; Karaca, Gokhan; Pehlivanli, Faruk; Altunkaya, Canan; Uzun, Hafize; Ozden, Huseyin; Guler, OsmanBackground: The present study investigated the effectiveness of platelet-rich plasma (PRP) and mesenchymal stem cells (MSCs) in wound healing suppressed by corticosteroid in rats. Methods: Forty rats were separated into four groups. To disrupt the wound-healing processes, intraperitoneal single dose 10 mg/kg methylprednisolone was administered to all rats with the exception of Sham-S group. Then, full-thickness incision was performed to the abdominal skin of all animals, and PRP or MSCs were applied to the incision line except the Sham-S and Sham-M group animals. Ten days later, all animals were sacrificed to investigate: tissue collagenization, inflammation, and re-epithelialization grades histopathologically; and tissue hydroxyproline (HP), interleukin-1 beta (IL-1 beta), tumor necrosis factor-alpha levels biochemically. Results: Collagenization (p = 0.003) and inflammation grade (p = 0.002) values were higher in PR group. Tissue HP level value was found to be high in MC group (p < 0.001). Tissue IL-1 beta level value of Sham-M group was lower than those of other groups (p < 0.001). Conclusions: This preliminary study revealed that PRP could improve the histopathological grades in wound healing which was suppressed by corticosteroid in rats, while MSCs could show their therapeutic effects via biochemical route. These positive effects were more salient in PR group.
