Platelet-Rich Plasma May Offer a New Hope in Suppressed Wound Healing When Compared to Mesenchymal Stem Cells
Yükleniyor...
Tarih
2018
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Mdpi
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Background: The present study investigated the effectiveness of platelet-rich plasma (PRP) and mesenchymal stem cells (MSCs) in wound healing suppressed by corticosteroid in rats. Methods: Forty rats were separated into four groups. To disrupt the wound-healing processes, intraperitoneal single dose 10 mg/kg methylprednisolone was administered to all rats with the exception of Sham-S group. Then, full-thickness incision was performed to the abdominal skin of all animals, and PRP or MSCs were applied to the incision line except the Sham-S and Sham-M group animals. Ten days later, all animals were sacrificed to investigate: tissue collagenization, inflammation, and re-epithelialization grades histopathologically; and tissue hydroxyproline (HP), interleukin-1 beta (IL-1 beta), tumor necrosis factor-alpha levels biochemically. Results: Collagenization (p = 0.003) and inflammation grade (p = 0.002) values were higher in PR group. Tissue HP level value was found to be high in MC group (p < 0.001). Tissue IL-1 beta level value of Sham-M group was lower than those of other groups (p < 0.001). Conclusions: This preliminary study revealed that PRP could improve the histopathological grades in wound healing which was suppressed by corticosteroid in rats, while MSCs could show their therapeutic effects via biochemical route. These positive effects were more salient in PR group.
Açıklama
Aydin, Oktay/0000-0001-5728-0128; Uzun, Hafize/0000-0002-1347-8498; Aydin, Gulcin/0000-0001-9672-7666; Sahiner, Ibrahim Tayfun/0000-0002-3921-7675
Anahtar Kelimeler
platelet-rich plasma, mesenchymal stem cell, wound healing
Kaynak
Journal Of Clinical Medicine
WoS Q Değeri
Q1
Scopus Q Değeri
Q1
Cilt
7
Sayı
6
Künye
Aydin O, Karaca G, Pehlivanli F, Altunkaya C, Uzun H, Özden H, Aydin G, Şahiner İT, Niyaz M, Güler O.(2018) Platelet-Rich Plasma May Offer a New Hope in Suppressed Wound Healing When Compared to Mesenchymal Stem Cells. Journal of Clinical Medicine; 7(6):143.
