Yazar "Haydardedeoglu, Ali Evren" seçeneğine göre listele

Listeleniyor 1 - 3 / 3
  • Küçük Resim
    Öğe
    Azithromycin therapy of papillomatosis in dogs: a prospective, randomized, double-blinded, placebo-controlled clinical trial
    (Wiley-Blackwell, 2008) Yagci, Bugrahan Bekir; Ural, Kerem; Ocal, Naci; Haydardedeoglu, Ali Evren
    Azithromycin, an azalide subclass macrolide antibiotic, is an effective, well-tolerated and safe therapeutic option for treatment of papillomatosis in humans. This study reports the clinical and histopathological results from a prospective, randomized, double-blinded, placebo-controlled trial of 17 dogs of various breeds with diagnosis of oral (n = 12) and cutaneous papillomatosis (n = 5) treated with azithromycin. Papillomas appeared as whitish, verrucous, hyperkeratotic papules 1-2.7 mm in size. The cases were randomly assigned to azithromycin (n = 10) and placebo treatment groups (n = 7). Both owners and investigators were blinded to the allocation to the groups. Azithromycin (10 mg/kg) was administered per os every 24 h for 10 days. Clinical evaluations were done by the same investigator throughout the trial. Azithromycin treatment significantly decreased clinical scores (P < 0.001), whereas there was no change seen in the placebo group. In the azithromycin treatment group, skin lesions disappeared in 10-15 days. One case in the placebo had spontaneous regression of its papillomas by day 41, but lesions were still evident at day 50 in the remaining six cases. There was no recurrence of papillomatosis in the azithromycin treated dogs (follow up 8 months). No adverse effects were seen in either group. In conclusion, azithromycin appears to be a safe and effective treatment for canine papillomatosis.
  • Küçük Resim
    Öğe
    Hepatogenous photosensitization in Akkaraman lambs: special emphasis to oxidative stress and thrombocytopenia
    (Ankara Univ Press, 2013) Ocal, Naci; Haydardedeoglu, Ali Evren; Cinar, Miyase; Kul, Oguz; Turk, Mustafa
    In this study, a total of 24 Akkaraman lambs with clinical signs that are reminiscent of photosensitization composed the experimental group (Group I). Additional 10 healthy lambs were included as controls (Group II). We were aimed to make definitive diagnosis of photosensitization, which can be confused with blue tongue, big head and sunburns and to establish etiology as primary or hepatogenous. In total blood analyses, the leukocyte count was higher, but thrombocyte count was lower (thrombocytopenia) in Group I compared to Group II. The lower MCV indicates presence of a case of microcytosis. Furthermore, affected lambs had significantly higher levels of phylloerythrin, gamma-glutamyl transpeptidase, aspartate aminotransferase, alkaline phosphatase, cholesterol and serum urea nitrogen. Histopathological lesions included periaciner necrosis, periportal fibrosis and biliary duct hyperplasy. The grazing field, where the lambs had been grazing, was very rich in Tribulus terrestris, a hepatotoxic plant. Based on the increased levels of phylloerythrin, gamma-glutamyl transpeptidase, aspartate aminotransferase and alkaline phosphatase as well as pathological findings in liver, the cases were diagnosed as hepatogenous photosensitization. In addition, presence of Tribulus terrestris in the grazing pasture strongly supported the diagnosis. Increased levels of serum malondialdehyde in affected lambs showed an ongoing oxidative stress. In addition, thrombocytopenia in such cases should be considered as a risk factor for disseminated intravascular coagulation (DIC). Thus in addition to a semptomatical treatment protocol, use of antioxidants, anticoagulants, and liver protective agents shoud be taken into consideration in hepatogenous photosensitization in lambs.
  • Küçük Resim
    Öğe
    Serum zinc concentrations in dogs with Microsporum canis dermatophytosis: a pilot study
    (Scientific Technical Research Council Turkey-Tubitak, 2009) Ural, Kerem; Karakurum, Mehmet Cagri; Duru, Oezkan; Cingi, Cenker Cagri; Haydardedeoglu, Ali Evren
    Zinc deficiency may result in alopecia, erythema, crusting, scaling, parakeratosis, inflammation of the skin, and impaired wound healing. Zinc deficiency also may impair the immune response against microorganisms and lead to fungal infections such as trichophytosis. The present study included male and female dogs (n = 7) of various breeds, ages, and diagnosed with Microsporum canis dermatophytosis and 4 healthy dogs used as the control group. The influence of dermatophytosis on serum zinc concentrations in dogs was investigated. Wood's lamp examination, fungal cultures, and additionally biopsy specimen were used to confirm the diagnosis and rule out other causes of the skin lesions. Serum zinc concenrations were determined by use of an atomic absorption spectrophotometer. No statistical difference was found in zinc concentrations between the dogs with dermatophytosis and normal dogs. Based upon the findings of this pilot study, no association was documented between the occurrence of dermatophytosis and the serum zinc concentrations.