Hepatogenous photosensitization in Akkaraman lambs: special emphasis to oxidative stress and thrombocytopenia
Yükleniyor...
Tarih
2013
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Ankara Univ Press
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
In this study, a total of 24 Akkaraman lambs with clinical signs that are reminiscent of photosensitization composed the experimental group (Group I). Additional 10 healthy lambs were included as controls (Group II). We were aimed to make definitive diagnosis of photosensitization, which can be confused with blue tongue, big head and sunburns and to establish etiology as primary or hepatogenous. In total blood analyses, the leukocyte count was higher, but thrombocyte count was lower (thrombocytopenia) in Group I compared to Group II. The lower MCV indicates presence of a case of microcytosis. Furthermore, affected lambs had significantly higher levels of phylloerythrin, gamma-glutamyl transpeptidase, aspartate aminotransferase, alkaline phosphatase, cholesterol and serum urea nitrogen. Histopathological lesions included periaciner necrosis, periportal fibrosis and biliary duct hyperplasy. The grazing field, where the lambs had been grazing, was very rich in Tribulus terrestris, a hepatotoxic plant. Based on the increased levels of phylloerythrin, gamma-glutamyl transpeptidase, aspartate aminotransferase and alkaline phosphatase as well as pathological findings in liver, the cases were diagnosed as hepatogenous photosensitization. In addition, presence of Tribulus terrestris in the grazing pasture strongly supported the diagnosis. Increased levels of serum malondialdehyde in affected lambs showed an ongoing oxidative stress. In addition, thrombocytopenia in such cases should be considered as a risk factor for disseminated intravascular coagulation (DIC). Thus in addition to a semptomatical treatment protocol, use of antioxidants, anticoagulants, and liver protective agents shoud be taken into consideration in hepatogenous photosensitization in lambs.
Açıklama
Anahtar Kelimeler
Lamb, malondialdehyde, microcytosis, oxidative stress, photosensitization, Tribulus terrestris, thrombocytopenia
Kaynak
Ankara Universitesi Veteriner Fakultesi Dergisi
WoS Q Değeri
Q4
Scopus Q Değeri
Q3
Cilt
60
Sayı
2
Künye
Öcal N., Haydardedeoğlu A. E., Çınar M., Kul O., Türk M. (2013). Hepatogenous photosensitization in Akkaraman lambs: special emphasis to oxidative stress and thrombocytopenia. Ankara Üniversitesi Veteriner Fakültesi Dergisi, 60(2), 116 - 122.
