Hepatogenous photosensitization in Akkaraman lambs: special emphasis to oxidative stress and thrombocytopenia

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dc.contributor.authorOcal, Naci
dc.contributor.authorHaydardedeoglu, Ali Evren
dc.contributor.authorCinar, Miyase
dc.contributor.authorKul, Oguz
dc.contributor.authorTurk, Mustafa
dc.date.accessioned2020-06-25T18:07:31Z
dc.date.available2020-06-25T18:07:31Z
dc.date.issued2013
dc.departmentKırıkkale Üniversitesi
dc.description.abstractIn this study, a total of 24 Akkaraman lambs with clinical signs that are reminiscent of photosensitization composed the experimental group (Group I). Additional 10 healthy lambs were included as controls (Group II). We were aimed to make definitive diagnosis of photosensitization, which can be confused with blue tongue, big head and sunburns and to establish etiology as primary or hepatogenous. In total blood analyses, the leukocyte count was higher, but thrombocyte count was lower (thrombocytopenia) in Group I compared to Group II. The lower MCV indicates presence of a case of microcytosis. Furthermore, affected lambs had significantly higher levels of phylloerythrin, gamma-glutamyl transpeptidase, aspartate aminotransferase, alkaline phosphatase, cholesterol and serum urea nitrogen. Histopathological lesions included periaciner necrosis, periportal fibrosis and biliary duct hyperplasy. The grazing field, where the lambs had been grazing, was very rich in Tribulus terrestris, a hepatotoxic plant. Based on the increased levels of phylloerythrin, gamma-glutamyl transpeptidase, aspartate aminotransferase and alkaline phosphatase as well as pathological findings in liver, the cases were diagnosed as hepatogenous photosensitization. In addition, presence of Tribulus terrestris in the grazing pasture strongly supported the diagnosis. Increased levels of serum malondialdehyde in affected lambs showed an ongoing oxidative stress. In addition, thrombocytopenia in such cases should be considered as a risk factor for disseminated intravascular coagulation (DIC). Thus in addition to a semptomatical treatment protocol, use of antioxidants, anticoagulants, and liver protective agents shoud be taken into consideration in hepatogenous photosensitization in lambs.en_US
dc.identifier.citationÖcal N., Haydardedeoğlu A. E., Çınar M., Kul O., Türk M. (2013). Hepatogenous photosensitization in Akkaraman lambs: special emphasis to oxidative stress and thrombocytopenia. Ankara Üniversitesi Veteriner Fakültesi Dergisi, 60(2), 116 - 122.en_US
dc.identifier.doi10.1501/Vetfak_0000002564
dc.identifier.endpage122en_US
dc.identifier.issn1300-0861
dc.identifier.issn1308-2817
dc.identifier.issue2en_US
dc.identifier.scopus2-s2.0-84874060889
dc.identifier.scopusqualityQ3
dc.identifier.startpage117en_US
dc.identifier.trdizinid142209
dc.identifier.urihttps://doi.org/10.1501/Vetfak_0000002564
dc.identifier.urihttps://hdl.handle.net/20.500.12587/5599
dc.identifier.volume60en_US
dc.identifier.wosWOS:000334986200007
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.publisherAnkara Univ Pressen_US
dc.relation.ispartofAnkara Universitesi Veteriner Fakultesi Dergisi
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectLamben_US
dc.subjectmalondialdehydeen_US
dc.subjectmicrocytosisen_US
dc.subjectoxidative stressen_US
dc.subjectphotosensitizationen_US
dc.subjectTribulus terrestrisen_US
dc.subjectthrombocytopeniaen_US
dc.titleHepatogenous photosensitization in Akkaraman lambs: special emphasis to oxidative stress and thrombocytopeniaen_US
dc.typeArticle

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