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    The comparative effect of propolis in two different vehicles; mouthwash and chewing-gum on plaque accumulation and gingival inflammation
    (Dental Investigations Society, 2015) Ercan N.; Erdemir E.O.; Ozkan S.Y.; Hendek M.K.
    Objective: In general, chemical plaque agents have been used in mouthwashes, gels, and dentifrices. In some situations, application of mouthwashes and dentifrices can be difficult. Therefore, different approaches for oral health-care have been needed. The aim of this study was to evaluate the effect of propolis chewing-gum compared to propolis-containing mouthwash on gingival inflammation and plaque accumulation on patients that refrained from daily oral hygiene procedures for 5 days. Materials and Methods: 10 college students with systemically healthy and very good oral hygiene and gingival health were included in this randomized, single-blind, crossover 5-day plaque regrowth with a 3-day washout period clinical study. After plaque scores were reduced to zero, participants were asked to refrain from oral hygiene procedures and allocated to either propolis mouthwash or chewing-gum group. Chewing-gum was performed after meals 3 times a day for 20 min mouthwash group was instructed to rinse mouthwash 2 times a day for 1 min. On day 5, the clinical periodontal measurements containing plaque and gingival indexes were taken from the participants. Results: The both plaque and gingival indexes of propolis mouthwash group were significantly lower than that of the propolis chewing-gum group (P = 0.005). Conclusion: It was demonstrated that the propolis mouthwash was more effective than the propolis chewing gum on the plaque inhibition and the gingival inflammation. © 2015 Dental Investigations Society.
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    Crevicular fluid levels of interleukin-8, interleukin-17 and soluble intercellular adhesion molecule-1 after regenerative periodontal therapy
    (Dental Investigations Society, 2015) Erdemir E.O.; Hendek M.K.; Keceli H.G.; Apan T.Z.
    Objective: The aim of this study is to evaluate the influence of regenerative periodontal therapy on clinical parameters and interleukin-8 (IL-8), IL-17 and soluble intercellular adhesion molecule-1 (sICAM-1) levels in gingival crevicular fluid (GCF) of subjects with chronic periodontitis (CP). Materials and Methods: Fifteen patients received demineralized freeze-dried bone allograft (DFDBA) surgically to the site of infrabony defect. Clinical periodontal indices were recorded, and GCF samples were collected at baseline and at the 6th and the 9th month after the surgery. Results: Except plaque index, all clinical parameters improved following surgery (P < 0.05). The volume of GCF diminished from baseline to follow-up periods (P < 0.05). However, no effect was observed on the total amount of IL-8, IL-17 and sICAM-1 in GCF. Conclusion: DFDBA improved clinical outcome in CP subjects and was effective on decreasing the volume of GCF, but no effect was determined on IL-8, IL-17 and sICAM-1. Findings did not indicate a direct relationship between biochemical parameters and periodontal healing after demineralized freeze-dried bone grafting. © 2015 Dental Investigations Society.
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    Fifteen months follow-up of a hopeless tooth treated with two-step procedure involving intentional replantation and free gingival graft
    (Dental Investigations Society, 2014) Keceli H.G.; Hendek M.K.
    The aim of the report is to document 15-month results of mucogingival surgery applied following intentional replantation (IntR). A mandibular left lateral incisor with severe periodontitis and malposition was replanted and splinted following root canal treatment. Three months after IntR, a free gingival graft (FGG) was placed. Fifteen months follow-up of the case demonstrated significant improvement in periodontal healing parameters and significant bone fill was detected around the root apex. As a conclusion, IntR may be speculated as a convenient alternative to keep the periodontally hopeless teeth and supportive approaches such as FGGs may improve the outcomes following IntR. © 2014 Dental Investigations Society.
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    Malondialdehyde levels and total antioxidant capacity in the dental follicles of the asymptomatic impacted third molars
    (Cumhuriyet University Faculty of Dentistry, 2015) Tekin U.; Kisa U.; Atil F.; Hendek M.K.; Dogan O.; Gurcan S.
    Objectives: Malondialdehyde (MDA), is one of many low molecular weight end products of lipid peroxidation (LPO), increases in oxidative stress. Antioxidants such as total antioxidant capacity (TAC) have a protective effect against reactive oxygen species. The aim of this study is to examine the development of the antioxidant defense mechanism in dental follicles (DFs) of radiologically asymptomatic impacted third molars (ITMs) by using MDA and TAC. Materials and Methods: This study involved 40 DFs of 40 patients referred for clinically and radiographically asymptomatic ITMs. 40 healthy gingival tissues in the same patients obtained during surgical removal of teeth as a control group. This study involved DFs widths on periapical radiographs narrower than 2.5 mm were included in the study. All of tissues samples were analyzed for MDA and TAC. Results: Levels of the MDA and TAC in DFs were significantly higher than the levels of MDA and TAC provided from healthy gingival tissues of the same patients (p<0.05). Conclusions: The results of our study showed that an important antioxidant defense mechanism may also occur in DFs of asymptomatic ITMs. In the light of these preliminary findings of the presented study, supplementary studies should be undertaken to establish the differences between inflammation affecting the DFs and clinical outcomes.