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  • Küçük Resim
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    The Effect of Chlorpyrifos on Isolated Thoracic Aorta in Rats
    (Hindawi Ltd, 2013) Yildirim, Ebru; Baydan, Emine; Kanbur, Murat; Kul, Oguz; Cinar, Miyase; Ekici, Husamettin; Atmaca, Nurgul
    This study investigated the effect of chlorpyrifos on thoracic aorta and on the level of NO in plasma and aorta. The effect of chlorpyrifos on thoracic aorta in organ bath was determined in 10 rats. Another 45 rats were assigned to 3 groups with 15 rats each: control group 1 received distilled water, control group 2 was given corn oil, and the last group was given 13.5 mg/kg chlorpyrifos dissolved in corn oil every other day for 8 weeks orally. Chlorpyrifos (10(-10) M-10(-5) M) showed no effect on isolated thoracic aorta. Plasma AChE activity was decreased, while LDH, ALT, GGT, and AST activities were increased in chlorpyrifos group compared to control groups. Plasma NO level was increased in chlorpyrifos group compared to control groups. iNOS expression was present in all groups in the cytoplasm of the endothelia and in the smooth muscle cells of aorta. According to semiquantitative histomorphological analysis, iNOS immunopositive reactions were seen in the decreasing order in chlorpyrifos, control 2, and control 1 groups. eNOS immunopositive reactions were observed in the endothelial cell cytoplasm, rarely in the subintimal layer, and the smooth muscle cells of aorta. There were no differences among the groups in terms of eNOS immunostaining. In conclusion, chlorpyrifos induced NO production in aorta following an increase in NOS expression.
  • Küçük Resim
    Öğe
    The Effects of Grape Seed on Some Biochemical Parameters in Ionophore
    (2015) Karabacak, Mürsel; Çınar, Miyase; Eraslan, Gökhan; Kanbur, Murat; Liman, Bilal Cem; Akçay, Aytaç
    Çalışmada günlük Ross MP3 ırkı erkek etlik civciv kullanıldı ve her grupta 10'ar hayvan bulunan 8 grup oluşturuldu.Birinci grup kontrol olarak tutuldu ve çalışma süresi boyunca normal yemle beslendi. Diğer gruplara sırasıyla üzüm çekirdeği(%0.5), lasalosid (100 ppm), salinomisin (60 ppm), maduramisin (5 ppm), lasalosid (100 ppm) ve üzüm çekirdeği (%0.5), salinomisin (60 ppm) ve üzüm çekirdeği (%0.5), maduramisin (5 ppm) ve üzüm çekirdeği (%0.5) 6 hafta süreyle yemle birlikteverildi. Çalışma süresi sonunda serum aspartat aminotransferaz (AST), alanın aminotransferaz (ALT), alkalen fosfataz (ALP),protein, albumin kolesterol, trigliserit, ürik asit, glikoz ve kreatinin değerleri incelendi. Üzüm çekirdeğinin belirtilen biyokimyasalparametreler üzerinde herhangi olumsuz bir etkisinin olmadığı gözlendi. Lasalosid'in ALT, trigliserit ve kreatinin düzeylerindeyükselmeye; salinomisin'in ALT, ALP, trigliserit ve kreatinin düzeylerinde yükselme ve albumin düzeyinde azalmaya; maduramisin'in ALT, ALP, trigliserit, ürik asit ve kreatinin düzeylerinde yükselmeye yol açtığı belirlendi. Üzüm çekirdeği+lasalosidverilen grupta ALT, ALP ve trigliserit düzeylerinin düştüğü; üzüm çekirdeği+salinomisin verilen grupta ALT ve trigliserit düzeyinin düştüğü; üzüm çekirdeği+maduramisin verilen grupta ALT, ALP, trigliserit, ürik asit ve kreatinin düzeylerinin düştüğü belirlendi (P<0.05). Lasalosid, salinomisin ve maduramisin'in etlik piliçlerde karaciğer ve böbrek fonksiyonları ile yağ metabolizması üzerinde olumsuz etkilerinin bulunduğu; ancak iyonofor antibiyotiklerle birlikte üzüm çekirdeği verilmesinin bu antibiyotiklerinyol açtığı istenmeyen etkileri azaltıcı etkilerinin olduğu belirlendi.
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    Öğe
    The Smooth Muscle Contractility In Aflatoxicated Broiler Chicken Ileum
    (Parlar Scientific Publications (P S P), 2013) Yildirim, Ebru; Aktuna, Zuhal; Yalcinkaya, Ilkay; Eraslan, Gokhan; Kanbur, Murat; Aydos, Tolga R.; Oruc, Ertan
    This study was conducted to investigate the contractility of aflatoxicated isolated broiler ileum smooth muscles. Fourty-eight, one-day old broiler chicks were divided into 4 groups, each containing 12 chicks. The 1st group was the control group, the 2nd group received 1 g/kg yeast glucomannan (Mycosorb), the 3rd group received 2 mg/kg aflatoxin, and the 4th group received 1 g/kg yeast glucomannan + 2 mg/kg aflatoxin in the feed. At the 21st day of the study, chicks were decapitated and the ileum isolated. Decapitation lasted on 28th day of the study. The isolated ileum strips were mounted under a basal tension of 1 g. The contractions of acetylcholine (ACh), nicotine, and bethanechol were calculated as g contraction/mg wet weight of ileum. For histopathologic examination, ileum sections were stained with hematoxylin-eosin and masson trichrome. The isolated ileum muscle contractions with ACh, nicotine, and bethanechol were not statistically significant in the study groups as compared to control group (P>0.05). Pathological examination revealed no histopathological changes in the smooth muscle tissues of the study group chicks when compared with control group. It is concluded that aflatoxins do not specifically change the contractility of broiler chick ileum to agonists most likely due to lack of aflatoxin-induced pathologic changes in the broiler chick ileum.