The Effect of Chlorpyrifos on Isolated Thoracic Aorta in Rats
Yükleniyor...
Tarih
2013
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Hindawi Ltd
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
This study investigated the effect of chlorpyrifos on thoracic aorta and on the level of NO in plasma and aorta. The effect of chlorpyrifos on thoracic aorta in organ bath was determined in 10 rats. Another 45 rats were assigned to 3 groups with 15 rats each: control group 1 received distilled water, control group 2 was given corn oil, and the last group was given 13.5 mg/kg chlorpyrifos dissolved in corn oil every other day for 8 weeks orally. Chlorpyrifos (10(-10) M-10(-5) M) showed no effect on isolated thoracic aorta. Plasma AChE activity was decreased, while LDH, ALT, GGT, and AST activities were increased in chlorpyrifos group compared to control groups. Plasma NO level was increased in chlorpyrifos group compared to control groups. iNOS expression was present in all groups in the cytoplasm of the endothelia and in the smooth muscle cells of aorta. According to semiquantitative histomorphological analysis, iNOS immunopositive reactions were seen in the decreasing order in chlorpyrifos, control 2, and control 1 groups. eNOS immunopositive reactions were observed in the endothelial cell cytoplasm, rarely in the subintimal layer, and the smooth muscle cells of aorta. There were no differences among the groups in terms of eNOS immunostaining. In conclusion, chlorpyrifos induced NO production in aorta following an increase in NOS expression.
Açıklama
BAYDAN, Emine/0000-0001-5459-8616
Anahtar Kelimeler
Kaynak
Biomed Research International
WoS Q Değeri
Q4
Scopus Q Değeri
Q1
Cilt
Sayı
Künye
Ebru Yıldırım, Emine Baydan, Murat Kanbur, Oğuz Kul, Miyase Çınar, Hüsamettin Ekici, Nurgül Atmaca, "The Effect of Chlorpyrifos on Isolated Thoracic Aorta in Rats", BioMed Research International, vol. 2013, Article ID 376051, 7 pages, 2013.
