The Effect of Chlorpyrifos on Isolated Thoracic Aorta in Rats

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dc.contributor.authorYildirim, Ebru
dc.contributor.authorBaydan, Emine
dc.contributor.authorKanbur, Murat
dc.contributor.authorKul, Oguz
dc.contributor.authorCinar, Miyase
dc.contributor.authorEkici, Husamettin
dc.contributor.authorAtmaca, Nurgul
dc.date.accessioned2020-06-25T18:07:41Z
dc.date.available2020-06-25T18:07:41Z
dc.date.issued2013
dc.departmentKırıkkale Üniversitesi
dc.descriptionBAYDAN, Emine/0000-0001-5459-8616
dc.description.abstractThis study investigated the effect of chlorpyrifos on thoracic aorta and on the level of NO in plasma and aorta. The effect of chlorpyrifos on thoracic aorta in organ bath was determined in 10 rats. Another 45 rats were assigned to 3 groups with 15 rats each: control group 1 received distilled water, control group 2 was given corn oil, and the last group was given 13.5 mg/kg chlorpyrifos dissolved in corn oil every other day for 8 weeks orally. Chlorpyrifos (10(-10) M-10(-5) M) showed no effect on isolated thoracic aorta. Plasma AChE activity was decreased, while LDH, ALT, GGT, and AST activities were increased in chlorpyrifos group compared to control groups. Plasma NO level was increased in chlorpyrifos group compared to control groups. iNOS expression was present in all groups in the cytoplasm of the endothelia and in the smooth muscle cells of aorta. According to semiquantitative histomorphological analysis, iNOS immunopositive reactions were seen in the decreasing order in chlorpyrifos, control 2, and control 1 groups. eNOS immunopositive reactions were observed in the endothelial cell cytoplasm, rarely in the subintimal layer, and the smooth muscle cells of aorta. There were no differences among the groups in terms of eNOS immunostaining. In conclusion, chlorpyrifos induced NO production in aorta following an increase in NOS expression.en_US
dc.description.sponsorshipKirikkale UniversityKirikkale University [2007/26]en_US
dc.description.sponsorshipThis research was supported by the Kirikkale University Research Fund, Project no. 2007/26. Some parts of this study were presented as an abstract in 3rd East Mediterranean ICLAS Symposium and XV. ICLAS General Assembly, June 13-15, 2011, Istanbul, Turkey. Poster no. PB 046, pp. 84.en_US
dc.identifier.citationEbru Yıldırım, Emine Baydan, Murat Kanbur, Oğuz Kul, Miyase Çınar, Hüsamettin Ekici, Nurgül Atmaca, "The Effect of Chlorpyrifos on Isolated Thoracic Aorta in Rats", BioMed Research International, vol. 2013, Article ID 376051, 7 pages, 2013.en_US
dc.identifier.doi10.1155/2013/376051
dc.identifier.issn2314-6133
dc.identifier.issn2314-6141
dc.identifier.pmid23878805
dc.identifier.scopus2-s2.0-84880158092
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1155/2013/376051
dc.identifier.urihttps://hdl.handle.net/20.500.12587/5640
dc.identifier.wosWOS:000321639000001
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherHindawi Ltden_US
dc.relation.ispartofBiomed Research International
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.titleThe Effect of Chlorpyrifos on Isolated Thoracic Aorta in Ratsen_US
dc.typeArticle

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