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Öğe Cerebral hemodynamics in ocular hypertension(Springer, 2005) Akarsu, Cengiz; Bilgili, Yasemin Karadeniz; Ünal, Birsen; Taner, Pelin; Ergin, Ahmet; Kara, Simay AltanPurpose: To evaluate the cerebral blood flow velocity in patients with ocular hypertension. Material and methods: Twenty-four ocular hypertensive patients and 24 age- and sex-matched healthy volunteers were recruited in a prospective comparative study. All subjects had normal findings on full-threshold visual field tests and clinically normal optic nerves. All patients with ocular hypertension had an intraocular pressure (IOP) of > 21 mmHg on three separate occasions without treatment. Systolic and diastolic blood pressure by cuff, heart rate by palpation, IOP by Goldmann applanation tonometry, central corneal thickness by ultrasound pachymetry, blood flow velocities, and pulsatility index of the ipsilateral middle cerebral artery by transcranial color Doppler were measured. Results: Systolic and diastolic blood pressures ( P= 0.40 and P= 0.45, respectively), heart rate ( P= 0.30), and central corneal thickness ( P= 0.23) were similar in each group. Peak and end-diastolic blood flow velocities in the middle cerebral artery did not differ between ocular hypertensives and controls ( P= 0.37 and P= 0.87, respectively). In addition, pulsatility index did not significantly differ between ocular hypertensives and controls ( P= 0.61). Conclusions: The results of this study suggest that ocular hypertension is not associated with reduction in blood flow velocity and elevation of resistance in the middle cerebral artery.Öğe Diagnosis and management of vaginal mullerian cyst in a virgin patient(Springer London Ltd, 2008) Cil, Aylin Pelin; Basar, M. Murad; Kara, Simay Altan; Atasoy, PinarBenign cystic lesions of the vagina are uncommon and may become symptomatic. We describe two symptomatic anterior vaginal wall cysts in a virgin patient and the usefulness of imaging modalities. A 36-year-old virgin woman presented with a complaint of vaginal bulging and pelvic pressure. Pelvic examination revealed a cystic mass protruding from the vagina surrounded by the intact hymen. The initial abdominopelvic ultrasound showed a hypoechoic cystic mass measuring 42 x 20 mm in the vagina. She then had a pelvic magnetic resonance imaging (MRI) that revealed two anterior vaginal wall cysts with no communication with the urethra or bladder. The cysts were excised and histologic examination with mucicarmine revealed mucin-secreting tall columnar cells consistent with a diagnosis of mullerian cyst. While both ultrasonographic examination and MRI are helpful in localizing vaginal cysts, MRI is superior in showing multiple cystic lesions of the vagina and their communication with the surrounding structures.Öğe Doğal menopozda hormon replasman tedavisinin renal arter doppler indekslerine etkisi: Ön çalışması(2006) Yücel, Aykan; Kara, Simay Altan; Noyan, Volkan; Sağsöz, Nevin; Çil, Aylin PelinObjektif: Bu çalışmanın amacı doğal menopozdaki hastalarda üç farklı hormon replasman tedavisinin (HRT) renal damarlar üzerine etkisini renal arter Doppler indeksleri ölçümü ile araştırmaktı. Planlama: Otuz üç postmenapozal hastaya randomize olarak sırasıyla 0.625 mg konjuge equine östrojen (CEE) 5 mg medroksiprogesteron asetat (MPA) (Grup I), 2 mg estradiol valerat (Grup II) ya da 2.5 mg Tibolon (Grup III) başlandı. Tedavi başlamadan önce ve başlangıçtan 70 gün sonra her hastaya sol interlobar renal arter Doppleri yapıldı. Ortam: Kırıkkale Üniversitesi Tıp Fakültesi Kadın Hastalıkları ve Doğum ve Kırıkkale Üniversitesi Tıp Fakültesi Radyoloji Anabilim Dalı Değerlendirme parametreleri: HRT başlangıç ve tedavi sonrasında interlobar renal arter Doppler indeksleri ölçümü SONUÇ: Toplam 33 hastadan grup I’ den 11, grup II’ den 7 ve grup III’ den 9 hasta çalışmaya dahil edildi. Bu 27 hastanın yaş ortalaması 49.44 4.07 idi. Tüm hastaların bazal pulsatilite (PI) ve resistivite indeks (RI) değerleri benzerdi. Yetmiş günlük tedavi sonrasında grup III’ teki hastaların RI (p0.001), grup II’ deki hastaların RI (p0.047) ve PI (p0.028) değerlerinde anlamlı düşüş izlendi. Grup I’ deki hastaların bazal ve tedavi sonrası RI ve PI değerlerinde ise anlamlı değişiklik olmadı. YORUM: Az sayıda hastayla yapılmış olan bu çalışmanın sonuçları Tibolon ve estradiol valerat’in renal kan akımı üzerine olumlu etkileri olabileceği ve östrojenle kombine kullanıldığında MPA’ ın östrojenin vasküler etkilerini azaltıcı etki yaratabileceğini düşündürmekte ise de, bu yargıyı destekleyecek iyi planlanmış daha fazla hastayla yapılmış, uzun süreli çalışmalara gereksinim vardır.Öğe Doppler sonography of the normal lacrimal gland(Wiley, 2005) Bilgili, Yasemin; Taner, Pelin; Ünal, Birsen; Simsir, İlknur; Kara, Simay Altan; Bayram, Merih; Alıcıoğlu, BanuPurpose. We used Doppler sonography to determine the resistance index (RI) and pulsatility index (PI) of the normal lacrimal artery (LA) in both females and males. We also compared the values obtained at various periods of reproductive life. Methods. The study was performed in 25 prepubertal girls, 28 females of reproductive age, and 27 postmenopausal women, 23 pregnant women, and 104 healthy males. Doppler sonography was used to determine the RI and PI of the LA. Results. The mean PI for the entire patient population was 1.48 +/- 0.60 and the RI was 0.72 +/- 0.09. The RI and PI values of the LA did not differ between males and females. Similarly, the mean RI and PI values of the LA did not change significantly between the various reproductive phases. Conclusion. The PI and Rl of the lacrimal gland are similar in both sexes. Moreover, they are not altered by changes in levels of sex steroids. (c) 2005 Wiley Periodicals, Inc. J Clin Ultrasound 33:123-126, 2005; Published online in Wiley InterScience (www.interscience.wiley.com).Öğe Effects of hormone replacement therapy on renal artery Doppler indices in women with natural menopause(Galenos Yayincilik, 2006) Yucel, Aykan; Kara, Simay Altan; Noyan, Volkan; Sagsoz, Nevin; Cil, Aylin PelinObjective: The aim of our study was to evaluate the effects of three different hormone replacement therapy (HRT) regimens on renal vasculature determined by renal artery Doppler ultrasonography indices in natural menopause. Design: Thirty three postmenopausal women were randomly assigned to receive 0.625 mg conjugated equine estrogen (CEE) + 5 mg medroxyprogesterone acetate (MPA) (Group I), 2 mg estradiol valerate (Group II) or 2.5 mg Tibolon (Group III), respectively. Doppler ultrasound of the left renal interlobar artery was performed for each patient before the beginning and after 70 days of each hormone replacement therapy (HRT). Setting: Kirikkale University, School of Medicine, Department of Gynecology and Obstetrics, and Department of Radiology, Kirikkale, Turkey. Main outcome measures: Renal interlobar artery Doppler indices before and after therapy. Results: Of the thirty three patients, there were 11, 7 and 9 patients who completed the study in group I, II and III, respectively. The mean age of 27 patients who completed the study was 49.44 +/- 4.07. The baseline pulsatility index (PI) and resistivity index (RI) values of the three groups were similar. After 70 days of treatment, there were statistically significant decrease in RI values of group III (p< 0.001) and RI (p=0.047) and PI (p=0.028) values of group II while statistically significant change was not obtained in group I after treatment. Conclusion: Although we may conclude from the results of this small sample sized study that tibolon and estradiol valerate may have favorable effects on renal blood flow and MPA combined with CEE may attenuate the estrogen-induced vascular effects in natural menopause, well designed studies with more patients and long term follow-up are needed to strengthen this judgment.Öğe Evaluation of acute trismus by MRI: a case report - Bilateral peritonsillar cellulitis(Springer, 2006) Muluk, Nuray Bayar; Kara, Simay Altan; Yazgan, ÇiselWe describe a rare case of a bilateral peritonsillar cellulites (PTC). The clinical presentation of fever, trismus and odynophagia was consistent with PTC, more evident on the right side; but the presence of bilateral tonsillar swelling and midline uvula confounded the diagnosis. In spite of the throat examination was performed with a great difficulty due to trismus, the T2 weighted fat saturated STIR magnetic resonance imaging (MRI) guided us to make the diagnosis and to start the intravenous antibiotic treatment immediately.Öğe Relationship between tinnitus loudness level and internal jugular venous flow rate measured by coloured Doppler ultrasonography in patients with a high jugular bulb(B C Decker Inc, 2005) Muluk, Nura Bayar; Kara, Simay Altan; Koç, CanThe aim of this study was to investigate the relationship between tinnitus loudness level (TLL) and internal jugular venous flow rate (IJVFR) in tinnitus patients with a unilateral high jugular bulb detected by temporal bone high-resolution computed tomography (HRCT). The study group consisted of 24 adult patients (13 male, 11 female) with a unilateral high jugular bulb. One ear suffered from tinnitus with a high jugular bulb was included into the study group. The ears without tinnitus and no high jugular bulb on temporal bone HRCT comprised the control group. All patients were evaluated with a history and physical and otolaryngologic examinations, and, using a questionnaire, TLLs were detected. The patency and flow rates in the internal jugular veins were measured by right and left internal jugular venous Doppler ultrasonography. The TLLs were "very quiet" in 1 (4.1%) patient, "intermediate loud" in 17 (70.9%) patients, and "very loud" in 6 (25.0%) patients. IJVFRs were not different in the study and control groups. In the study group, IJVFRs were not correlated with age. There was no relationship among TLLs and IJVFRs, dominance, dehiscence, and bony septum thickness between the high jugular bulb and the middle ear. TLLs were not affected by IJVFRs, dominance, dehiscence, and bony septum thickness in patients with a high jugular bulb. More detailed studies should be undertaken to determine the reason for the different TLLs in patients with a high jugular bulb.Öğe Romatoid artritli olgularda krikoaritenoid eklem değişikliklerinin klinik ve bilgisayarlı tomografi bulgularının karşılaştırılması(2002) Kara, Simay Altan; Bayar, Nuray; Keleş, Işık; Altınok, Deniz; Koç, Can; Orkun, SevimRomatoid artrit etyolojisi bilinmeyen, simetrik erozif atini ve multisistem tutulumuyla giden otoimmün bir hastalıktır. Krikoaritenoid eklemler romatoid artritten etkilenen gerçek diartroidal eklemlerdir. Çalışmamızda, romatoid artritli olgularda bu eklemlerdeki değişikliklerin semptom, fizik muayene ve bilgisayarlı tomografi bulguları karşılaştırıldı. Romatoid artrit tanıtı 15 olguda, 30 krikoaritenoid eklemin üstüste binme tekniği ile elde edilen bilgisayarlı tomografi görüntüleri incelendi. Sonuçlar, semptom ve fizik muayene bulgularıyla karşılaştırıldı. Krikoaritenoid eklemde %66.7 olguda semptom, %13.3 olguda fizik muayene, %80 olguda bilgisayarlı tomografi pozitifti. Krikoaritenoid eklem incelemesinde, kıkırdaklarda volüm (%30), dansite artışı (%30), sublüksasyon (%20), eklemde belirginleşme (%16.7) ve eklem mesafesinde daralma (%6.7) saptandı. Bilgisayarlı tomografi romatoid artritli olgularda klinik bulgu vermeyen krikoaritenoid eklem değişikliklerini göstererek olguların olası risklere karşı korunmasını sağlar. Eklem değişikliklerinin gösterilmesi ve takibinde kullanılabilecek başarılı bir görüntüleme yöntemidir.Öğe Uterus didelfis ve renal agenezis(2003) Bilgili, Yasemin; Ünal, Birsen; Bayram, Merih; Şimşir, İlknur; Kara, Simay AltanAmaç: Alt kadran ağrısı ile başvuran 15 yaşındaki kadın hastanın US ve MRG ile değerlendirilmesi. Materyal ve Metod: Karın ağrısı etiyolojisinin saptanabilmesi için olguya US ve MRG tetkikleri yapıldı. Bulgular: US ve MRG yapılması ile olguda, uterus didelfis, unilateral vajinal subseptus ve ipsilateral renal agenezis saptandı. Sonuçlar:US ve MRG alt kadran ağrısının etiyolojisinin aydınlatılmasında, tedavinin planlanmasında ve fertilitenin korunarak gereksiz cerrahi işlemlerden hastanın korunmasında önem taşımaktadır.