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Öğe Changes in cardiac cells due to ticagrelor and enoxaparin in a rat ischemia/reperfusion model(Assoc Medica Brasileira, 2021) Findik, Orhan; Baris, Ozgur; Yazir, Yusufhan; Yilmaz, Melda Yardimoglu; Rencber, Selenay Furat; Sarihan, Kubra Kavram; Kunt, Atike TekeliOBJECTIVE: Studies on ischemia/reperfusion injury remain the focus of interest. Ticagrelor and enoxaparin, which are antiaggregant and anticoagulant drugs developed for use in many cardiovascular pathologies, are still included in many ischemia/reperfusion studies. Remarkably, their new protective effects, especially with regard to ticagrelor, continue to be reported in the current literature. The aim of this study was to evaluate the beneficial effects of ticagrelor and enoxaparin pretreatments on the rat heart with histological and immunohistochemical markers in an ischemia/reperfusion model. METHODS: Wistar-albino rats (weighing 350-400 g) were divided into four groups as follows: Sham-Control (Group 1), Control-Saline+ischemia/reperfusion (Group 2), Ticagrelor+ischemia/reperfusion (Group 3), and Enoxaparin+ischemia/reperfusion (Group 4). The ischemia/reperfusion injury model was applied to Group 2, Group 3 and Group 4. Heart tissue sections were stained with hematoxylin and eosin for histological examinations. Caspase 3 immunostaining was evaluated to detect apoptosis in the heart tissue sections. RESULTS: Both pretreatments ameliorated the ischemic damage but especially tissue sections belonging to Group 3 were nearly similar to control levels. The results indicated that ischemia/reperfusion-induced myocardial damage was significantly increased in Group 2, whereas ticagrelor and enoxaparin pretreatments in Group 3 and Group 4 significantly decreased apoptotic scores and the histological appearance of the Group 3 close to the normal myocardium (p<0.001). CONCLUSION: As supported by histological findings in our study, ticagrelor and enoxaparin have protective properties for heart tissue in this ischemia/reperfusion injury model.Öğe Does Aspartate Aminotransferase to Alanine Aminotransferase Ratio Predict Acute Kidney Injury After Cardiac Surgery?(Forum Multimedia Publishing, Llc, 2021) Gultekin, Yildirim; Bolat, Ali; Hatice, Keles; Kunt, Atike TekeliBackground: Aspartate aminotransferase (AST) to alanine aminotransferase (ALT) ratio (AST/ALT) frequently is used in the diagnosis and prognosis of liver diseases, however it is also used in the diagnosis and prognosis of many other diseases, such as myocardial infarction, acute ischemic stroke, and peripheral artery disease. Acute kidney injury (AKI) is one of the most important complications after cardiac surgery and is one of the main causes of morbidity and mortality. The purpose of the study was to analyze the relationship between AST to ALT and AKI after isolated coronary artery bypass graft surgery (CABG). Methods: We retrospectively reviewed the prospectively collected data of 253 adult patients, who underwent isolated CABG surgery with normal renal function (baseline serum creatinine value <1.4 mg/dL). Preoperative (T0) and postoperative day 1 and day 3 (T1 and T2) serum AST and ALT levels were analyzed, and AST/ALT was calculated. A preoperative AST/ALT of 1.22 was found to be the best cutoff point for predicting postoperative AKI. Kidney injury was interpreted, according to RIFLE classification. The effect of AST to ALT ratio on AM after CABG was determined using logistic regression analysis, and the results were expressed as odds ratio (OR) with a 95% confidence interval (CI). A P value < .05 was considered statistically significant. Results: Postoperative AKI occurred in 40 patients (15.8%). On logistic regression analysis, higher AST/ALT both preoperatively and postoperatively were associated with an increased incidence of postoperative AKI (T0: OR, 3.983; 95% CI, 1.940-8.180, P < .001, T1: OR, 2.760; 95% CI, 1.381-5.515, P = .004, T2: OR, 2.515; 95% CI, 1.195-5.294, P = .015). Conclusion: Preoperative and postoperative elevated AST to ALT ratio seems to be associated with an increased incidence of AKI after elective isolated CABG surgery.Öğe Krill Oil Prevents Atherosclerosis in an Experimental Model(2021) Gültekin, Yıldırım; Bolat, Ali; Kunt, Atike TekeliObjectives: The major aim of coronary artery disease management is to reduce the formation and progression of atherosclerotic plaque. Omega-3 fatty acid supplementation that is obtained from fish has been shown to reduce cardiovascular events. Krill (Euphasia superba) are small crustaceans that live in cold seas like the Antarctic Ocean. Recently, due to its high content, and form of the eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), krill oil has become popular in researches dealing with the prevention of cardiac disorders and cancer. This study aims to analyze the effect of krill oil supplements on atherosclerosis in rats treated with high-fat diet and streptozotocin-induced diabetes mellitus. Materials and Methods: Twenty Sprague-Dawley male rats were split into two groups: the control group (C group) and the krill oil group (KO group). Each group was fed with a high-fat diet for six months and streptozotocin was injected subcutaneously to obtain an experimental model of atherosclerosis. The KO group received a 50 mg daily supplement of krill oil orally. Rats were sacrificed after six months for biochemical and histopathological examinations of the aorta and coronary arteries. Results: The atherosclerosis model was confirmed by elevated levels of low-density lipoprotein (LDL), triglyceride (TG), total cholesterol (TC), and glucose, also decreased insulin and high-density lipoprotein (HDL). The atherosclerosis index (TC/HDL) was lower in the C group compared to the KO group (p=0.012). Serum native thiol and total thiol levels were higher; however, the disulfide level was lower in the KO group. This result was statistically significant (p<0.001).In the KO group, there was a significant decrease in the number of foam cells discovered in the tissue examined from the aorta and coronary arteries with hematoxylin and eosin staining. Conclusions: The present study indicates that krill oil supplements attenuate the number of foam cells in the aorta and coronary arteries, indicating the preventive effect of krill oil on atherosclerosis.Öğe Mediastinal adipose tissue and aortic measurements in thorax CT: is it related to atherosclerosis?(2023) Sarıkaya, Pelin Zeynep Bekin; Kunt, Atike TekeliAim: We aimed to investigate whether the mediastinal adipose tissue plays a role in thoracic aortic atherosclerosis with thoracic Computed Tomography (CT) imaging. We aimed to elucidate the relationship between the amount and density of mediastinal adipose tissue, age, sex, and the presence of atherosclerotic plaque in the aorta. Material and Method: In this retrospective study, the thoracic computed tomography (CT) images of 45 patients (21 men and 24 women) were examined in two groups. There were 23 patients aged >60 years in group 1 and 22 patients aged <60 years in group 2. The measurements were manually performed from the image where the mediastinal fat tissue, located anterior compartment of the aorta and the pulmonary artery, is viewed widest. The area and density of mediastinal fat tissue, the diameter of the aorta and the distance from the anterior of the aorta to the sternum were measured. The narrowest distance between the aorta and the pulmonary artery, and the subcutaneous fat tissue thickness from the anterior of the sternum in the same section were measured. The presence and absence of atherosclerotic plaque in the aorta were also recorded. Results: We found no significant differences in demographic and clinical data between the groups. Among the patients aged >60 years (group 1) and <60 years (group 2), statistically significant differences in fat density, sternal fat thickness, and aortic diameter were found. Age was associated with the presence of atherosclerotic plaque. A statistically significant relationship was observed between sternal fat thickness and atherosclerotic plaque. The sternal fat thickness was greater in those with than in those without atherosclerotic plaques. The presence of atherosclerotic plaque was associated with aortic diameter. No statistically significant relationships were observed between the presence of atherosclerotic plaque and the amount and density of mediastinal fat, the aortosternal distance, and the aortopulmonary artery distance. Conclusion: The risk of atherosclerosis increases not only with excess adipose tissue but also depending on many other parameters. While evaluating atherosclerotic risk and plaque development, patient age, sex, fat distribution, and other diseases should also be evaluated. It should be kept in mind that atherosclerosis is still an unexplained multifactorial parameter in development.Öğe Multidimensional Evaluation of Pulmonary Function and Exercise Capacity by BODE Index in Patients with On-Pump Coronary Artery Bypass Grafting(Excerpta Medica Inc-Elsevier Science Inc, 2021) Baris, Ozgur; Findik, Orhan; Baris, Serap Argun; Benli, Emre Demir; Duzyol, Cagri; Kunt, Atike TekeliCoronary artery bypass grafting (CABG) often causes physiological changes in patients. Although functional changes, such as lung function and exercise capacity changes, are observed in patients, there are no detailed studies examining this. The aim was to compare preoperative and postoperative pulmonary function and exercise capacity in patients undergoing on-pump CABG with a multidimensional index (BODE index). Demographic and surgical characteristics of patients were recorded. Pulmonary function test, six-minute walk test (6MWT), and modified Medical Research Council (mMRC) dyspnea score were assessed and BODE index were calculated in preoperative and at six months postoperatively. A total of 75 patients were included with a mean +/- standard deviation age of 59.8 +/- 10.0 years. The male to female ratio was 57/18. There was a statistically significant decrease in the forced expiratory flow at 25-75% (FEF25-75%) value after CABG. Other pulmonary function test values were also lower in the postoperative period compared to the preoperative period, but these changes were not significant. The mean distance achieved in the 6MWT (p=0.02) and the mMRC dyspnea score (p=0.001) were significantly better postoperatively. The BODE index, which combines these parameters, had increased in the postoperative period. Age (OR 1.09; 95% CI: 1.008-1.181) and postoperative FEF25-75% (OR -0.96; 95% CI: 0.938-0.988) were the independent predictors of BODE score >= 3 in multivariate analysis. Despite the decrease in pulmonary function in patients undergoing CABG, there was an improvement in exercise capacity and dyspnea score. (C) 2021 Elsevier Inc. All rights reserved.Öğe Myocardial protection in adult Bland-White-Garland syndrome(WILEY, 2020) Kunt, Atike Tekeli; Tumer, Naim Boran; Arsan, Sinan[Özet Yok]Öğe Preoperative Vitamin D Level is Associated with Postoperative Delirium After Cardiac Surgery in Patients Over 65 Years of Age(FORUM MULTIMEDIA PUBLISHING, LLC, 2020) Tumer, Naim Boran; Kunt, Atike Tekeli; Gunaydin, Serdar; Ozisik, KanatIntroduction: Delirium after cardiac surgery is a devastating and important complication. Delirium is defined as "disturbance in attention (i.e., reduced ability to direct, focus, sustain, and shift attention) and awareness (reduced orientation to the environment)." In this study, we analyzed the association of preoperative vitamin D levels and postoperative delirium after cardiac surgery in patients over 65 years. Materials and methods: We retrospectively reviewed the data of 212 adult patients above 65 years of age who underwent isolated coronary artery bypass graft surgery from January 2016 to January 2018. The mean age for Group I was 69.7 +/- 7.4 and Group II was 70.6 +/- 4.8 years. There were 112 female patients in Group I and 46 female patients in Group II. The patient population was divided into 2 groups based on preoperative serum vitamin D (25-hydroxyvitamin D [25-OHD]) levels (normal range of 25-75nmol/L). Group I included patients with preoperative serum 25-OHD level<25nmol/L. Group II included patients with preoperative serum 25-OHD level >= 25nmol/L. Results: The incidence of delirium in this study was 30.2%. In this study, 138 patients (65.1%) had preoperative serum 25-OHD levels <25 nmol/L, and 74 patients (34.9%) had preoperative serum 25-OHD levels >= 25 nmol/L. Preoperative serum 25-OHD levels were associated with postoperative delirium after coronary artery bypass graft surgery. Our retrospective study illustrated that a lower preoperative serum level of 25-OHD was associated with postoperative delirium. Our results showed that 65.1% of patients had preoperative serum 25-OHD levels <25 nmol/L, and this was associated with postoperative delirium. Conclusion: Vitamin D deficiency exacerbates delirium after coronary artery bypass surgery with cardiopulmonary bypass. Whether the effects of vitamin D deficiency during this event represent separate or interrelated activities with cardiopulmonary bypass is an important question to address and prospective randomized studies are necessary to confirm these results.Öğe Preoperative Vitamin D Level Predicts Operative Mortality After Cardiac Surgery(2020) Kunt, Atike Tekeli; Tümer, Naim Boran; Özışık, Kanat; Günaydın, SerdarObjectives: The present study aimed to analyze the prognostic value of preoperative serum vitamin D level in patients who underwent coronary artery bypass graft (CABG) surgery. Materials and Methods: The data of 360 adult patients who underwent isolated CABG surgery were retrospectively reviewed. We reached the data of preoperative serum vitamin D [25-hydroxyvitamin D (25-OHD)] values of 305 patients. The patient population was divided into two groups based on preoperative serum 25-OHD levels with a normal range of 25-75 nmol/L (group I: patients with preoperative serum 25-OHD level <25 nmol/L and group II: patients with preoperative serum 25-OHD level ?25 nmol/L). The effect of preoperative 25-OHD level on operative mortality (mortality which occurred during the first 30 days after the operation) was determined using regression analysis and the results were expressed as Odds ratio (OR) with a 95% confidence interval (CI). A p value <0.05 was considered statistically significant. Results: In the present study, operative mortality was 3.93% (n=12). One hundred and fifty seven patients (51.5%) had serum 25-OHD levels <25 nmol/L. The mean serum 25-OHD levels were significantly lower in females than in males (p<0.001). On logistic regression analysis, preoperative serum 25-OHD level was found to be independently associated with operative mortality (OR: 0.201, 95% CI: 0.043- 0.935; p=0.041). Conclusion: The presence of vitamin D deficiency seems to be an independent predictor of operative mortality after cardiac surgery in this retrospective study; however, prospective randomized trials are warranted to clarify the effect of preoperative vitamin D supplementation on postoperative outcomes in cardiac surgical patients.Öğe Procedural and mid-term outcomes of carotid artery stenting and carotidendarterectomy in asymptomatıc patients: A single center experience(2020) Budak, Ali Baran; Sarıyıldız, Husniye; Günertem, Eren; Kulahcıoglu, Emre; Orhan, Gurdal; Tümer, Naim Boran; Kunt, Atike TekeliAim: Atherosclerotic carotid artery stenosis (CS) is responsible for ~20% of strokes. The management of CS in an asymptomatic patient has been less clear. In situations were carotid endarterectomy (CEA) is thought to be more risky, surgeons must also have enough experience and capability to perform carotid artery stenting (CAS) to provide suitable, patient-tailored treatment. In this study, the same investigator performed all interventions (CAS and CEA), and one type of stenting device and EPD was used. In addition, periprocedural monitoring was carried out for at least 24 h. The objective of this study was to compare procedural results and 12-month follow-up outcomes of patients who were treated by the same operator- either CAS or CEA- in one year.Material and Methods: A retrospective single-center review involving asymptomatic patients with severe stenosis of the ICA caused by atherosclerotic disease who was treated with either stenting with embolic protection (Group 1, n=17) or carotid endarterectomy (group 2, n=18) according to their clinical and anatomical risk profile between 1 January 2018 and 31 December 2018 at Numune Research and Training Hospital, Department of Cardiovascular Surgery, Ankara-Turkey was conducted. A duplex ultrasound (DUS) and neurological assessment was obtained prior to hospital discharge as a baseline, 30-days, 6 months, and 1 year thereafter. Patients’ demographic and clinical characteristics, angiographic variables, primary endpoints including the composite of death, stroke and myocardial infarction during the 30 days after the procedure or ipsilateral stroke during the 365 days after the procedure was compared. Primary endpoints also including primary technical success, periprocedural clinical success, primary patency, clinical failure, periprocedural adjunctive maneuvers and secondary endpoints including complications, freedom from clinically driven target-lesion revascularization at 12 months, freedom from death, freedom from all stroke and freedom from restenosis rates were assessed and compared between the groups. Results: High-risk anatomical criteria were present in 8 (47.0%) patients, high-risk clinical criteria were present in 11 (64.7%) patients. Group 2 patients were older (67.7±7.4 vs 71.2± 6.9, p<0.05), but hyperlipidemia (58.8% vs 44.4%, p<0.05), chronic renal insufficiency requiring hemodialysis (11.7% vs 0.0%, p<0.05) and left ventricular dysfuntion (17.6% vs 0.0%, p<0.05) were significantly more frequent in Group 1. CCDS of group 1 was significantly lower than group 2 (4.7 ± 1.3 vs 7.3 ± 1.2; p<0.05, respectively). The lesions of the patients undergoing CEA were significantly longer (12.7 ± 2.6 vs 18.5 ± 4.2 mm.; p<0.05) and more calcified (11.7% vs 50.0%, p<0.05) than the patients in group 1. Likewise, the degree of stenosis in group 2 was significantly more than that of group 1 (81.4 ± 4.2 vs 88.3±6.4 %; p<0.05, respectively). Primary technical success was 100% for both groups. Periprocedural clinical success was 100% for Group 1, and 94.4% for group 2. Primary patency rates at 1/6/12 months were 100%/ 94.1%/94.1% for group 1, and 100%/100%/94.4% for group 2. Freedom from restenosis and freedom from CD-TLR at 12 months was 94.1% and 94.4% for group 1 and group 2. No death, major strokes, miyocardial infarction and systemic complications occured.Conclusion: This study showed similar short and mid-term results for CEA and CAS in asymptomatic patients with significant carotid disease. Although we have shown good results for both CEA and CAS, CAS should be limited to those cases that are not suitable for open surgery and treatment of asymptomatic carotid artery disease with CEA should be considered for patients with few risk factors and long life expectancy. Both CEA and CAS reduce the long-term stroke risk in asymptomatic patients. The appropiate treatment strategy should be selected according to the patient’s individual risk factors and imaging data.Öğe Subclinical Hypothyroidism Increases the Requirement of Renal Replacement Therapy After Cardiac Surgery(FORUM MULTIMEDIA PUBLISHING, LLC, 2020) Tumer, Naim Boran; Kunt, Atike Tekeli; Keles, Hatice; Ozisik, Kanat; Gunaydin, SerdarBackground: Subclinical or biochemically diagnosed hypothyroidism (SCH) is defined as an elevated serum thyroid-stimulating hormone (TSH) with normal free thyroxine (FT4) levels. Thyroid hormones play a major role in the normal function of the heart and vascular physiology. Atherosclerosis, increased systemic vascular resistance, and decreased arterial compliance are common pathophysiological changes that may occur in hypothyroidism. Acute kidney injury (AKI) is one of the devastating complications after cardiac surgery. Age, diabetes mellitus (DM), preexisting renal dysfunction, hypertension, impaired left ventricular function, and severe arteriosclerosis are the major risk factors for the development of AKI. The purpose of the current study was to analyze the influence of SCH on AM and the requirement of renal replacement therapy (RRT) after isolated coronary artery bypass graft surgery (CABG). Methods: We retrospectively reviewed the prospectively collected data of 336 adult patients who underwent isolated CABG surgery with normal renal function (baseline serum creatinine value <1.4 mg/dL) from January 2017 to January 2019. The patients were divided into two groups either having the diagnosis of SCH (Group I, N = 47) or not (Group II, N = 289). SCH was diagnosed based on preoperative serum TSH and FT4 levels. Kidney injury was interpreted, according to RIFLE classification. The effect of SCH on AM and the need for RRT after CABG was determined using logistic regression analysis and the results were expressed as odds ratio (OR) with a 95% confidence interval (CI). A P value < .05 was considered statistically significant. Results: Subclinical hypothyroidism was diagnosed in 14% of all patients. Postoperative AKI occurred in 15 patients (31.9%) in Group I, whereas there were 42 patients (14.5%) in Group II. On logistic regression analysis, the presence of SCH was shown to be associated with an increased incidence of postoperative AKI (OR, 0.363; 95% CI, 0.181-0.727; P = .004). RRT was used in 2.97% of patients (seven patients in Group I and three patients in Group II, P < .001). The 30-day mortality was 2.1%. Conclusion: The presence of SCH seems to be associated with an increased incidence of AKI and increased requirement for RRT after cardiac surgery.Öğe The effect of desmopressin and tranexamic acid on blood product use and postoperative bleeding after emergent isolated coronary artery bypass grafting (CABG) surgery(2020) Tümer, Naim Boran; Kunt, Atike Tekeli; Günaydın, Serdar; Özışık, Kanat; Günertem, Eren; Budak, Ali Baran; Babaroglu, SeyhanAim: Bleeding is a major problem in cardiac surgery, and results in a high risk of allogeneic blood transfusion associatedwith increased morbidity and mortality. In recent years, studies in the literature reported that desmopressin (1-deamino-8-D-arginine vasopressin, DDAVP) reduces the blood loss after surgical interventions. The aim of the present study is to analyzethe effect of desmopressin and tranexamic acid on blood product use and postoperative bleeding in patients that werepretreated with P2Y12 inhibitors by cardiologists and undergone emergent coronary artery bypass grafting (CABG) surgery.Material and Methods: The prospectively collected data of 62 adult patients who underwent emergent isolated CABGsurgery and pretreated with P2Y12 inhibitors by cardiologists were retrospectively reviewed. The perioperative data of thepatients included their demographic data, laboratory findings, the amount of blood loss from chest tubes, the amount ofblood product use, need of re-thoracotomy, morbidity and mortality. The patient population was divided into two groups:Group I: Patients that received tranexamic acid and DDAVP perioperatively (n=26); and Group II: Patients that receivedonly tranexamic acid perioperatively (n=36).Results: The two groups of patients had similar characteristics at baseline. There was a statistically significant differencebetween Group I and II regarding postoperative blood loss from the chest tubes, re-thoracotomy, red blood cell andthrombocyte transfusions (p<0.05). No statistically significant differences were observed between the two groups interms of fresh frozen plasma transfusion, inotropic support and mortality.Conclusion: We suggest that desmopressin in addition to tranexamic acid reduces bleeding and the amount of bloodproduct use in patients undergoing emergent isolated CABG surgery.Öğe The effect of postoperative administration of low-molecular-weight-heparin (tinzaparin) on arterial thrombosis in an experimental rat model(2024) Gültekin, Yıldırım; Bolat, Ali; Özbayburtlu, Merih; Keleş, Hatice; Kunt, Atike TekeliIntroduction: Low molecular weight heparins are licensed in the prophylaxis of venous thromboembolism but not of arterial thrombosis. This study aimed to evaluate the effect of postoperative administration of low molecular weight heparin, tinzaparin, on the rate of arterial thrombosis in a rat model. Methods: The right femoral arteries of sixteen male Wistar Albino rats were incised transversely and then were repaired with a continuous suture. Eight rats were given 175 IU/kg/day tinzaparin postoperatively for three days, while the remaining eight rats were kept free of tinzaparin. All rats were controlled daily for vascular circulation, bleeding, and hematoma until the reoperation on the fourth postoperative day. Reoperation was performed to explore vascular patency and excise a sample of vascular tissue from the repaired femoral artery for histopathological examination. A blood sample was also withdrawn for the detection of anti-factor Xa activity to show the efficacy of tinzaparin. Results: During the postoperative three-day follow-up period, while vascular circulation disorder was detected in none of the tinzaparin- treated rats, it was detected in two rats not treated with tinzaparin (25%). None of the rats in either group developed bleeding or hematoma at the surgical site. Anti-factor Xa activity in the rats treated with tinzaparin postoperatively was found to be significantly higher than in the rats not treated with tinzaparin (p<0.001). Histopathological examination revealed thrombus and fibrin formation at the femoral artery incision line in only one rat (12.5%) treated with tinzaparin, and in seven rats (87.5%) not treated with tinzaparin (p?0.001). Intimal hyperplasia was not detected in any group, but mixed-type inflammatory cell infiltration and endothelial and fibroblastic activity around the sutures were noted in both. Conclusion: The postoperative subcutaneous administration of 175 IU/kg/day tinzaparin effectively attenuates the rate of arterial thrombosis in arterial surgical interventions in a rat model.Öğe Varis Ameliyatı Olan Hastaların Taburculuk Sonrası Öz Bakımlarının Değerlendirilmesi(2023) Şahbaz, Burcu; Koçaşlı, Sema; Kunt, Atike TekeliAmaç: Bu çalışmada, venöz yetmezlik nedeniyle varis gelişen hastaların taburculuk sonrası öz bakımlarının değerlendirilmesi amaçlandı. Gereç ve Yöntem: Araştırma, bir hastanenin kalp ve damar cerrahisi kliniğine Şubat 2019- Mayıs 2019 tarihleri arasında venöz yetmezlik nedeniyle başvuran ve ameliyat kararı verilen, çalışmaya katılmayı kabul eden 101 hasta ile tamamlandı. Veriler hastalara ameliyat öncesi, ameliyat sonrası sıfırıncı gün ve taburculuktan bir ay sonra veri toplama formu, Öz Bakım Gücü Ölçeği ve Görsel Analog Skala kullanılarak toplandı. Bulgular: Hastaların yaş ortalaması 48,9 ± 12,6 yıl ve %71,3’ü kadındı. Ameliyat öncesi Öz Bakım Gücü Ölçeği puanlarının (98,7 ± 21,1) taburculuk sonrası puanlarından (91,8 ± 25,3) daha yüksek olduğu tespit edildi (p = 0,045). Hastaların %73,3’ünün gün içindeki aktivitelerini ayakta çalışarak geçirdikleri, %56,4’ünün daha önce varislere bağlı semptom yaşadığı saptandı. Hastaların taburculuk sonrası %24,8’i düzenli olarak varis çorabı giymediğini, %63,4’ü bacak elevasyonu yapmadığını ve varis çorabını yanlış giydiğini, %24,8’i uygun aktiviteleri yapmadığını, %80,2’si ağrısının olduğunu ifade etti. Sonuç: Elde edilen veriler sonucunda venöz yetmezlik nedeniyle ameliyat olan hastaların taburculuk sonrası öz bakımlarının yetersiz olduğu tespit edildi. Bu nedenle hemşirelerin taburculuk sonrası eğitimlerde hastaların öz bakımlarını artırıcı bilgilere ağırlık vermesi önerilebilr.
