The effect of desmopressin and tranexamic acid on blood product use and postoperative bleeding after emergent isolated coronary artery bypass grafting (CABG) surgery
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Tarih
2020
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Aim: Bleeding is a major problem in cardiac surgery, and results in a high risk of allogeneic blood transfusion associatedwith increased morbidity and mortality. In recent years, studies in the literature reported that desmopressin (1-deamino-8-D-arginine vasopressin, DDAVP) reduces the blood loss after surgical interventions. The aim of the present study is to analyzethe effect of desmopressin and tranexamic acid on blood product use and postoperative bleeding in patients that werepretreated with P2Y12 inhibitors by cardiologists and undergone emergent coronary artery bypass grafting (CABG) surgery.Material and Methods: The prospectively collected data of 62 adult patients who underwent emergent isolated CABGsurgery and pretreated with P2Y12 inhibitors by cardiologists were retrospectively reviewed. The perioperative data of thepatients included their demographic data, laboratory findings, the amount of blood loss from chest tubes, the amount ofblood product use, need of re-thoracotomy, morbidity and mortality. The patient population was divided into two groups:Group I: Patients that received tranexamic acid and DDAVP perioperatively (n=26); and Group II: Patients that receivedonly tranexamic acid perioperatively (n=36).Results: The two groups of patients had similar characteristics at baseline. There was a statistically significant differencebetween Group I and II regarding postoperative blood loss from the chest tubes, re-thoracotomy, red blood cell andthrombocyte transfusions (p<0.05). No statistically significant differences were observed between the two groups interms of fresh frozen plasma transfusion, inotropic support and mortality.Conclusion: We suggest that desmopressin in addition to tranexamic acid reduces bleeding and the amount of bloodproduct use in patients undergoing emergent isolated CABG surgery.
Açıklama
Anahtar Kelimeler
Genel ve Dahili Tıp, Sağlık Bilimleri ve Hizmetleri, Kalp ve Kalp Damar Sistemi, Cerrahi
Kaynak
Turkish Journal of Clinics and Laboratory
WoS Q Değeri
Scopus Q Değeri
Cilt
11
Sayı
3
