The effect of desmopressin and tranexamic acid on blood product use and postoperative bleeding after emergent isolated coronary artery bypass grafting (CABG) surgery

Basit Öğe Kaydı
dc.contributor.authorTümer, Naim Boran
dc.contributor.authorKunt, Atike Tekeli
dc.contributor.authorGünaydın, Serdar
dc.contributor.authorÖzışık, Kanat
dc.contributor.authorGünertem, Eren
dc.contributor.authorBudak, Ali Baran
dc.contributor.authorBabaroglu, Seyhan
dc.date.accessioned2025-01-21T16:17:21Z
dc.date.available2025-01-21T16:17:21Z
dc.date.issued2020
dc.departmentKırıkkale Üniversitesi
dc.description.abstractAim: Bleeding is a major problem in cardiac surgery, and results in a high risk of allogeneic blood transfusion associatedwith increased morbidity and mortality. In recent years, studies in the literature reported that desmopressin (1-deamino-8-D-arginine vasopressin, DDAVP) reduces the blood loss after surgical interventions. The aim of the present study is to analyzethe effect of desmopressin and tranexamic acid on blood product use and postoperative bleeding in patients that werepretreated with P2Y12 inhibitors by cardiologists and undergone emergent coronary artery bypass grafting (CABG) surgery.Material and Methods: The prospectively collected data of 62 adult patients who underwent emergent isolated CABGsurgery and pretreated with P2Y12 inhibitors by cardiologists were retrospectively reviewed. The perioperative data of thepatients included their demographic data, laboratory findings, the amount of blood loss from chest tubes, the amount ofblood product use, need of re-thoracotomy, morbidity and mortality. The patient population was divided into two groups:Group I: Patients that received tranexamic acid and DDAVP perioperatively (n=26); and Group II: Patients that receivedonly tranexamic acid perioperatively (n=36).Results: The two groups of patients had similar characteristics at baseline. There was a statistically significant differencebetween Group I and II regarding postoperative blood loss from the chest tubes, re-thoracotomy, red blood cell andthrombocyte transfusions (p<0.05). No statistically significant differences were observed between the two groups interms of fresh frozen plasma transfusion, inotropic support and mortality.Conclusion: We suggest that desmopressin in addition to tranexamic acid reduces bleeding and the amount of bloodproduct use in patients undergoing emergent isolated CABG surgery.
dc.identifier.doi10.18663/tjcl.733844
dc.identifier.endpage99
dc.identifier.issn2149-8296
dc.identifier.issue3
dc.identifier.startpage93
dc.identifier.trdizinid415185
dc.identifier.urihttps://doi.org/10.18663/tjcl.733844
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/415185
dc.identifier.urihttps://hdl.handle.net/20.500.12587/22620
dc.identifier.volume11
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.relation.ispartofTurkish Journal of Clinics and Laboratory
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20241229
dc.subjectGenel ve Dahili Tıp
dc.subjectSağlık Bilimleri ve Hizmetleri
dc.subjectKalp ve Kalp Damar Sistemi
dc.subjectCerrahi
dc.titleThe effect of desmopressin and tranexamic acid on blood product use and postoperative bleeding after emergent isolated coronary artery bypass grafting (CABG) surgery
dc.typeArticle

Dosyalar

Koleksiyon

TR-Dizin İndeksli Yayınlar Koleksiyonu