Yazar "Kurtman, Cengiz" seçeneğine göre listele

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  • Küçük Resim
    Öğe
    Alterations in serum biochemical parameters of patients with lung cancer exposed to radiotherapy
    (Triveni Enterprises, 2010) Çavuşoğlu, Kültigin; Arıca, Şükran Çakır; Kurtman, Cengiz
    In this study, the alterations in serum biochemical parameters of patients with lung cancer exposed to radiotherapy was investigated. For this aim, the levels of serum gamma glutamyltransferase (GGT), as part ate aminotransferase (AST), alanine aminotransferase (ALT), albumin (ALB), bilurubin (BLB), copper (Cu), sodium (Na) and potassium (K) were evaluated before and after radiotherapy. Serum enzyme, protein, Na and K levels were determined using an autoanalyzer Serum Cu analysis was made with Atomic Absorbtion Spectrophotometre (AAS). Although we found significant increases in levels of GGT, BLB, Cu and Kin patients, levels of AST, ALT, ALB and Na in patients showed significant decreases. The levels of serum AST and ALT fairly decreased after radiotherapy The level of GGT in patients was significant higher than that in the controls before radiotherapy However, GGT level showed again a distinctly decrease after radiotherapy There was an inverse relationship among serum BLB, Cu and ALB values. Besides, serum Na levels showed significantly decrease in patients at the end of radiotherapy treatment compared to the controls and before radiotherapy and K levels increased significantly following radiotherapy In conclusion, the selected serum parameters are very sensitive and useful biomarkers for the study of the effects of radiotherapy
  • Küçük Resim
    Öğe
    Chromosomal aberrations induced by radiotherapy in lymphocytes from patients with lung cancer
    (Triveni Enterprises, 2009) Cavuşoğlu, Kültigin; Arıca, Şükran Çakır; Bökesoy, Işık; Kurtman, Cengiz
    In this study we tried to define incidence and types of chromosomal aberrations (CAs) caused by radiotherapy (RT) in circulating lymphocytes from patients with lung cancer. For this purpose, we used cumulative dose-effect relationship, and correlate these data with statistical parameters. CAs were evaluated in terms of chromosome break, dicentric, ring and chromosome gap. Abnormal metaphase number (AMN) was also calculated. Chromosome studies were carried out in peripheral blood lymphocytes of 20 cancer patients receiving RT Patients were treated with 10 Gy of gamma (gamma) radiation during five wk(s). In all patients, a significant increase in AMN and frequency of CAs (e.g. chromosome break, dicentric, ring and chromosome gap) observed during the RT depend on cumulative radiation dose when compared to before RT and this increase was statistically significant (p<0.05). The highest CAs frequency was observed at the end of fifth wk. Among the CAs, chromosome breaks have a high incidence. But no CAs and abnormal metaphase was observed in lymphocytes before RT The present study showed that RT possess a significant effect in increasing of CAs and chromosome break, dicentric, ring and chromosome gap are very sensitive and useful biomarkers in the study of this effect. In other words, these CAs may be used as possible fingerprints of RT.
  • Küçük Resim
    Öğe
    The frequency of micronuclei and morphological effects on white blood cells following radiotherapy
    (2009) Çavuşoğlu, Kültiğin; Arıca, Çakır Şükran; Kurtman, Cengiz
    Bu çalışmada, akciğer tümörleri nedeniyle radyoterapiye (RT) maruz kalan kanser hastalarının periferal kan örneklerindeki morfolojik hasarları ve mikronukleus (MN) sıklığını belirlemeye çalıştık. Bu amaçla, in vivo kümülatif doz-etki ilişkisini kullandık ve bu verileri istatistiksel parametreler ile ilişkilendirdik. Sitolojik analizler, ?–radyasyonuna maruz kalan hastaların beyaz kan hücrelerinde (WBC) gerçekleştirildi. MN testi, radyasyon hasarının bir belirteci olarak kullanıldı. Ayrıca, sigara alışkanlığı ve yaş gibi farklı faktörlerin etkileride MN testi kullanılarak araştırıldı. MN sayımı, tek nükleuslu lenfositlerde gerçekleştirildi. WBC'nin sayısı ve morfolojik özelliklerini belirlemek amacıyla periferal kan yayma preparatları hazırlandı. Sonuçlar, ?–radyasyonuna maruz kalan kanser hastalarının WBC'deki MN sıklığı ve morfolojik hasarların, kontrol grubundakilerden oldukça yüksek olduğunu gösterdi ve fark istatistiksel olarak önemliydi (P0.01). WBC'de voküolizasyon, membran kusurları ve sitoplazmik granülasyonda artış gibi morfolojik değişmeler belirlendi. Ayrıca, radyasyon dozuna bağlı olarak MN sıklığında bir artış ve WBC'nin sayısında ise bir azalma gözlendi. Sonuç olarak, morfolojik hasarlar ve MN sıklığının, RT 'nin etkilerini araştırmak için çok hassas ve kullanışlı biyolojik belirteçler olduğu gösterildi.