Yazar "Ocal, Naci" seçeneğine göre listele
Listeleniyor 1 - 8 / 8
Sayfa Başına Sonuç
Sıralama seçenekleri
Öğe Azithromycin therapy of papillomatosis in dogs: a prospective, randomized, double-blinded, placebo-controlled clinical trial(Wiley-Blackwell, 2008) Yagci, Bugrahan Bekir; Ural, Kerem; Ocal, Naci; Haydardedeoglu, Ali EvrenAzithromycin, an azalide subclass macrolide antibiotic, is an effective, well-tolerated and safe therapeutic option for treatment of papillomatosis in humans. This study reports the clinical and histopathological results from a prospective, randomized, double-blinded, placebo-controlled trial of 17 dogs of various breeds with diagnosis of oral (n = 12) and cutaneous papillomatosis (n = 5) treated with azithromycin. Papillomas appeared as whitish, verrucous, hyperkeratotic papules 1-2.7 mm in size. The cases were randomly assigned to azithromycin (n = 10) and placebo treatment groups (n = 7). Both owners and investigators were blinded to the allocation to the groups. Azithromycin (10 mg/kg) was administered per os every 24 h for 10 days. Clinical evaluations were done by the same investigator throughout the trial. Azithromycin treatment significantly decreased clinical scores (P < 0.001), whereas there was no change seen in the placebo group. In the azithromycin treatment group, skin lesions disappeared in 10-15 days. One case in the placebo had spontaneous regression of its papillomas by day 41, but lesions were still evident at day 50 in the remaining six cases. There was no recurrence of papillomatosis in the azithromycin treated dogs (follow up 8 months). No adverse effects were seen in either group. In conclusion, azithromycin appears to be a safe and effective treatment for canine papillomatosis.Öğe Effects of Total Parenteral Nutrition in the Treatment of Dogs with Parvoviral Hemorrhagic Gastroenteritis(Kafkas Univ, Veteriner Fakultesi Dergisi, 2009) Ocal, Naci; Unsuren, HikmetIn this study, a total of 30 dogs of different breeds and gender, with 2 to 6 months of age and 5-16 kg in body weights were used. The parvokit were used to confirm the PVGE in dogs with hemorrhagic gastroenteritis. Twenty dogs with Parvoviral gastroenteritis (PVGE) were randomly divided into two groups: a traditional treatment group (Group II) and Modified Treatment group (Group III). In Group III, dogs were given. Total Parenteral Nutrition (TPN) in addition to the traditional treatment procedure. Ten healthy dogs served as control. The affects of TPN was evaluated based on haematological parameters, blood gases values and blood biochemical profiles in blood samples. Prior to treatment, presence of hypoproteinemia and hypoglycemia in most the dogs with PVGE was interpreted as having protein calorie malnutrition (PCM) related to PVGE. Presence of leukocytopenia in diseased dogs indicated presence of lymphoid insufficiency and immune suppression consequence to the virus effects on lymphoid tissues. Based on clinical findings and the results of laboratory examinations, Lactated Ringer in 5% dextrose solution was intravenously given to all sick dogs to reduce the effects of acidosis and dehydration. In addition, 1.3% NaHCOT was administered intravenously to diseased dogs with a base excess status greater than -10. Dogs in modified treatment group also received TPN. Against secondary infections, ceftadizim at 25 mg/kg/daily was given intravenously to the dogs with PVGE. Up to the end of the study, 5 dogs (50%) in the traditional treatment group and one dog in modified treatment group died. As a result, total parenteral nutrition in the treatment of PVGE was found more successful than the traditional treatment as evidenced by the lower mortality rate.Öğe Endemic Contagious Agalactia in Sheep and Goats: Clinical Evaluation, Treatment and Vaccination(Medwell Online, 2010) Macun, Hasan Ceyhun; Ocal, Naci; Karahan, Murat; Yagci, Bugrahan Bekir; Kalender, Hakan; Kalin, RecepIn this study, it aimed to evaluate clinical signs of Contagious Agalactia (CA) that had been affecting small ruminants in Kirikkale Province for 1.5 years and to intervene with this endemic CA by administration of enrofloxacin 5 mg kg(-1) for 5 days and a single dose of meloxicam (0.5 mg kg(-1)) to acutely infected animals and by vaccination of the flocks. The study was conducted between July 2007 and December 2008 on a total of 745 animals of 5 different flocks with problems of mastitis, keratoconjunctivitis and arthritis. Clinically determined CA was also confirmed by PCR analysis of milk samples. Arthritis was the most frequently observed clinical sign with a rate of 71.84% in diseased animals. Arthritis was observed either as a single problem or concurrently with mastitis or ocular lesions. The co-existence rate of ocular lesions with mastistis was 2.91% while observing all three lesions concomitantly was the least frequent, 2.91%. Ocular lesions alone was not seen in ewes and goats but co-existed with other signs. Ewes and goats exhibited a higher frequency of mastitis alone with a rate of 45 and 44.83%, respectively compared to other two clinical signs. The treatment protocol mentioned above was successful as the general body condition of the clinically diseased animals was improved and subsequently no incidence of death was observed. Animals gradually recovered from mastititis and conjunctivitis and the severity of keratoconjunctivitis and arthritis was decreased. It also concluded that application of a live CA vaccine twice with a 6 month-interval was quite effective as no case of CA was observed in vaccinated flocks during a 1 year follow-up period.Öğe The Flumethrin Applications in Brown Swiss Cross Calves(Kafkas Univ, Veteriner Fakultesi Dergisi, 2008) Ocal, Naci; Ergin, SeydaIn this study, we aimed to compare dermatological examination findings in the applied skin region following local application of 1% flumethrin pour-on solution at a dose of 1 ml/10 kg. The study was conducted on a total of 50 Brown Swiss cross male calves kept under a half-open feedlot. Their ages ranged from 8 months to 12 months and their weight ranged from 180 kg to 250 kg. Of the calves, 40 calves (Group 1, n=20; Group 11, n=20) received flumethrin solution treatment along the midline of the back from the front of the shoulders to the tail setting. Remaining 10 calves were kept as a control group (Group 111). During the study, calves in groups I and III exposed to direct sun light while calves in Group 11 were kept in the part of the barn with no sun light exposure. At the 1th hour, 1th day, and 7th day following flumethrin application, the applied skin region was examined as clinically. The data were analyzed using One-Way Anova-Tukey. There were no significant differences among groups for the skin thickness and skin lesions (p > 0.05). Based on the clinical findings, we concluded that application of flumethrin pour-on solution at a dose of 1 ml/10 kg does not induce dermatological abnormalities in Brown Swiss cross calves, exposed to sunlight or kept indoors.Öğe Hepatogenous photosensitization in Akkaraman lambs: special emphasis to oxidative stress and thrombocytopenia(Ankara Univ Press, 2013) Ocal, Naci; Haydardedeoglu, Ali Evren; Cinar, Miyase; Kul, Oguz; Turk, MustafaIn this study, a total of 24 Akkaraman lambs with clinical signs that are reminiscent of photosensitization composed the experimental group (Group I). Additional 10 healthy lambs were included as controls (Group II). We were aimed to make definitive diagnosis of photosensitization, which can be confused with blue tongue, big head and sunburns and to establish etiology as primary or hepatogenous. In total blood analyses, the leukocyte count was higher, but thrombocyte count was lower (thrombocytopenia) in Group I compared to Group II. The lower MCV indicates presence of a case of microcytosis. Furthermore, affected lambs had significantly higher levels of phylloerythrin, gamma-glutamyl transpeptidase, aspartate aminotransferase, alkaline phosphatase, cholesterol and serum urea nitrogen. Histopathological lesions included periaciner necrosis, periportal fibrosis and biliary duct hyperplasy. The grazing field, where the lambs had been grazing, was very rich in Tribulus terrestris, a hepatotoxic plant. Based on the increased levels of phylloerythrin, gamma-glutamyl transpeptidase, aspartate aminotransferase and alkaline phosphatase as well as pathological findings in liver, the cases were diagnosed as hepatogenous photosensitization. In addition, presence of Tribulus terrestris in the grazing pasture strongly supported the diagnosis. Increased levels of serum malondialdehyde in affected lambs showed an ongoing oxidative stress. In addition, thrombocytopenia in such cases should be considered as a risk factor for disseminated intravascular coagulation (DIC). Thus in addition to a semptomatical treatment protocol, use of antioxidants, anticoagulants, and liver protective agents shoud be taken into consideration in hepatogenous photosensitization in lambs.Öğe A new approach to Neospora caninum infection epidemiology: neosporosis in integrated and rural dairy farms in Turkey(Scientific Technical Research Council Turkey-Tubitak, 2014) Ocal, Naci; Atmaca, Hasan Tarik; Albay, Metin Koray; Deniz, Ahmet; Kalender, Hakan; Yildiz, Kader; Kul, OguzBoth cattle and dogs were examined in modern and rural dairy farms that had a history of abortion over 5%. The blood samples were collected from 427 aborted cattle and the sera were tested using a commercial ELISA test kit. Additionally, a necropsy procedure was carried out on the fetuses and calves dead within 2 months after birth; the tissue samples were evaluated by histopathologic, immunoperoxidase, and PCR techniques. Eighteen dogs in close contact with the cattle in the same field were included in the study and blood and feces samples were collected. The feces samples were analyzed by copro-PCR and the sera were tested by indirect fluorescent antibody test. As a result, 161 out of 427 sera samples (37.7%) were found positive for N. caninum. In cattle, the lowest seropositivity was 6.7% and the highest seropositivity was 74.24%. Neosporosis seroprevalence in integrated holdings was lower than those of rural dairy cattle facilities (66.7%). The seropositivity for N. caninum in dogs was determined as 72.7% in rural holdings and 28.6% in integrated holdings. According to the risk analysis, N. caninum-seropositive cows had greater exposure to N. caninum-seropositive dogs in rural family holdings and integrated holdings (P = 0.054, odds ratio = 0.929; and P= 0.008, odds ratio = 0.986, respectively).Öğe Pica as a Predisposing Factor for Traumatic Reticuloperitonitis in Dairy Cattle: Serum Mineral Concentrations and Hematological Findings(Medwell Online, 2008) Ocal, Naci; Gokce, G.; Gucus, A. I.; Uzlu, E.; Yagci, B. B.; Ural, K.In this study, 30 dairy cattle suffering from pica-related symptoms and exhibiting clinical signs of Traumatic Reticuloperitonitis (TRP) and 25 clinically healthy dairy cattle were examined for serum zinc, iron, copper and calcium levels as well as hematological cell counts. No specific clinical signs of mineral deficiency were observed in cattle suffering from pica and TRP were determined. In hematological examination, a mild nonregenerative, normocytic-normochromic anemia detected in cattle suffering from pica and TRP based on the followings: a significant decrease (p<0.001) in erythrocyte count (4.88 x 10(12) L(-1)), MCV (54 +/- 0.53 fl) level within the range of the reference value and Hb (83.0 +/- 3.64 g L(-1)) and PCV (0.266 +/- 0.01 1 L(-1)) both of which were near the lower reference limits. A neutrophilia (49.33 +/- 2.207%) (p<0.001) associated with lymphopenia (45.0 +/- 2.22%) was determined in blood cell count. Compared to clinically healthy cattle, dairy cattle suffering from pica-related symptoms and exhibiting clinical signs of TRP (group 1) had significantly decreased Zn (9.547 +/- 0.51 mu mol L(-1)) (p<0.001), Cu (7.193 +/- 0.41 mu mol L(-1)) (p<0.05) and Ca (2.41 +/- 015 mmol L(-1)) (p<0.01) and mildly elevated Fe (50.649 +/- 5.03 mu mol L(-1)) (p<0.05) concentrations. The results suggest that Zn, Cu and Ca deficiencies are associated with pica and may play an important role in its etiology. Taking the status of lactation, pregnancy and milk yield of the dairy cattle into consideration, rations should be supplemented according to mineral deficiency in soil and plants that may prevent the onset of pica, which is a an important predisposing factor for TRP.Öğe Reactivated and clinical Toxoplasma gondii infection in young lambs: Clinical, serological and pathological evidences(Elsevier Science Bv, 2012) Atmaca, Hasan Tarik; Ocal, Naci; Babur, Cahit; Kul, OguzIn this study, fatal toxoplasmosis with severe neurological clinical signs was evaluated in 20 lambs of a sheep flock containing 90 Akkaraman sheep, 60 lambs and 3 rams. The clinical signs in infected lambs (n = 20) included incoordination, head shaking, tremors, shaking up, difficulty walking and subsequent death. No incidence of abortion observed in pregnant ewes. Two lambs with severe clinical signs were euthanized and necropsied following clinical and hematological examinations. Blood samples were also collected from the mothers of dead lambs and rams for Sabin-Feldman dye test to detect Toxoplasma gondii-specific antibodies. T. gondii infection was further confirmed by PCR analysis using T. gondii B1 gene specific primers. The histopathological findings included non-purulent myositis with T. gondii-like tissue cysts in the heart and skeletal musculature, severe necrotic vasculitis and multifocal necroses in the brain, liver and lungs. T. gondii immunoreactivity was present in the lungs, liver and spleen as well as tissue cyst-like structures. In differential diagnosis, Neospora caninum infection was excluded by immunohistochemical and PCR analyses. According to current literature, there has been no previous report on clinical toxoplasmosis in newborn lambs or goat kids, and the number of reports on clinical toxoplasmosis in small ruminants is limited to two adult goats with fatality following systemic toxoplasmosis. Our study indicated that toxoplasmosis occurs in lambs with severe neurological signs and subsequent death. (C) 2012 Elsevier B.V. All rights reserved.
