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    Comparison of Microsurgical and Conventional Techniques for Augmentation of Keratinized Mucosa Around Dental İmplants
    (2024) Solakoglu, Gamze; Hendek, Meltem Karsıyaka; Olgun, Ebru
    Objective: This study aims to compare the clinical outcomes of periodontal microsurgery with conventional periodontal surgery in keratinized mucosa augmentation around the implant. Materials and Methods: Ten patients with at least 2 implants with a keratinized mucosal width of < 2 mm were included. Free gingival graft (FGG) was applied in the test group with the microsurgery technique whereas in the control group with the conventional periodontal surgery technique. Keratinized mucosa width (KMW) and palatal mucosal thickness (MT) were measured at baseline and 3rd month. Graft shrinkage(GS) was evaluated at the 3rd month. Donor site wound healing was evaluated at the 10th day and 3rd month. Feedback forms were collected on the 10th day. Results: KMW values increased significantly in both groups at 3rd month compared to baseline. The percentage of GS was lower in the test group at 3rd month, but this difference was not significant. MT values in the test group were closer to the baseline values at 3rd month compared to the control group. Wound healing scores were similar in both groups at the 10th day and 3rd month. Postoperative pain levels decreased more rapidly in the test group. Conclusion: The microsurgical technique provides a faster increase in palatal mucosal thickness and lower graft shrinkage during the healing period and an earlier reduction in postoperative pain levels.
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    Comparison of the clinical, radiographic, and histological effects of titanium-prepared platelet rich fibrin to allograft materials in sinus-lifting procedures
    (Wiley, 2018) Olgun, Ebru; Ozkan, Serdar Y.; Atmaca, Hasan T.; Yalim, Mehmet; Hendek, Meltem Karsiyaka
    Aim: In the present study, we evaluated the clinical, radiographic, and histological comparisons of completely autologous titanium-prepared platelet rich fibrin (T-PRF) or allograft in sinus-lifting procedures. Methods Eighteen posterior maxilla requiring sinus-lifting procedures using the balloon-lifting technique for implant placement were selected. Ten sinuses were randomly assigned to T-PRF as the test group and eight to allografts as the control group. After 4 and 6 months in the test and control groups, respectively, computed tomography was done, and bone samples were received during implant surgery. Three months after the second surgery, implant stability was measured. Results: Radiological results showed that the allograft group had better results (62% in volume, 53% in density, and 69% in height) than the T-PRF group. Histomorphometric results showed that newly-formed bone ratios were 17.28 +/- 2.53 and 16.58 +/- 1.05 in the allograft group and T-PRF groups, respectively. There was no significant difference between the test and control groups (P = .611) for implant stability values. Conclusions: The use of T-PRF alone in sinus-lifting operations has successful clinical and histomorphometric results. Bone formation in the T-PRF group was accelerated to 4 months compared to allografts according to the histological results.
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    Comparison of two techniques in gingival recession treatment A randomized one-year clinical follow-up study
    (Wroclaw Medical Univ, 2022) Evginer, Mustafa Serdar; Olgun, Ebru; Parlak, Hanife Merva; Dolgun, Anil Barak; Keceli, Huseyin Gencay
    Background. Gingival recession (GR) is highly prevalent in the general population and represents a significant concern for patients and clinicians. Various surgical techniques have been proposed to treat gingival recession. Well-designed trials with clinician-and patient-based parameters, evaluating the envelope connective tissue graft (E-CTG) and semilunar coronally advanced flap (SCAF) techniques are still needed. Objectives. The aim of this trial was to compare the effectiveness of E-CTG and SCAF in the treatment of GR during a 1-year follow-up. Material and methods. A total of 42 patients with GR were treated with E-CTG (n = 20) or SCAF (n = 22). Clinician-based recordings of recession depth (RD), recession width (RW), probing depth (PD), clinical attachment level (CAL), keratinized tissue width (KTW), tissue thickness (TT), clinical attachment gain (CAG), root coverage (RC), keratinized tissue change (KTC), and wound healing index (WHI), as well as patient-based parameters of dentine hypersensitivity (DH), tissue appearance, patient expectations, and esthetics were collected at baseline (BL), 6 weeks (T1), 6 months (T2), and 1 year (T3). Results. After the treatment, E-CTG demonstrated better outcomes than SCAF in terms of CAG (50.70% vs. 33.33%), RC (85.60% vs. 35.60%) and KTC (1.70 +/- 1.49 mm vs. 0.36 +/- 0.96 mm) at T3. Similar findings were detected in terms of WHI, tissue appearance, patient expectations, and esthetics. Although inconvenient surgical experience was recorded, better results were obtained after E-CTG in terms of DH and meeting the RC expectations. Conclusions. Despite it being more difficult surgical experience and the risk of keloid formation, E-CTG was superior to SCAF in terms of RC percentage, reducing DH and obtaining satisfactory RC. However, it is still necessary to improve patient comfort in the case of E-CTG.
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    Diş hekimliğinde esansiyel yağların kullanımı
    (2022) Yankı, Çağla; Hendek, Meltem Karşıyaka; Olgun, Ebru
    Periodontal hastalık, mevcut oral floranın disbiyozu nedeniyle periodonsiyumun yıkımına yol açan ilerleyici, enfeksiyöz bir inflamatuvar hastalıktır. Patojenik mikroorganizmalar, periodontal hastalığın etiyolojik faktörüdür, patojene karşı gelişen immüno-inflamatuvar yanıt hastalığın ilerlemesinde rol oynar. Periodontal hastalık sırasında, reaktif oksijen türlerinin as?ırı üretimi ile onları detoksifiye eden antioksidanların yetersizlig?i sonucu oksidatif stres meydana gelir. Oksidatif stres, periodonsiyumun yıkımına neden olmaktadır. Bu nedenle, reaktif oksijen türlerinin antagonisti olarak, antioksidanlar periodontal hastalıkların tedavisinde yardımcı olabilmektedir. Bitkiler, periodontal sag?lıg?ın korunmasında es?siz rol oynayan bazı dikkat çekici özelliklere sahiptir. Bu özellikler geleneksel periodontal tedavinin sonuçlarını iyiles?tirebilecek potansiyele sahiptir. Bu derlemenin amacı, periodontal hastalıkların tedavisine potansiyel katkıları olan çes?itli esansiyel yağlar hakkında bilgi vermektir.
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    Effect of Initial Periodontal Treatment on Cardiovascular Risk Markers in Patients with Severe Chronic Periodontitis
    (Galenos Yayincilik, 2019) Hendek, Meltem Karsiyaka; Olgun, Ebru; Kisa, Ucler
    Objective: The aim of the study was to determine the influence of initial periodontal treatment in patients with severe chronic periodontitis on inflammatory markers related to risk for cardiovascular diseases. Materials and Methods: A total of 80 non-smokers with systemically healthy, including 40 patients (29 female, 11 male) with severe chronic periodontitis (test group) and 40 periodontally healthy participants (21 female, 19 male) (control group) were included into the present study. The probing depth, clinical attachment level, plaque index, gingival index and blood samples were collected at baseline and at the 3rd months after treatment and the serum levels of asymmetric dimethylarginine (ADMA), endothelial nitric oxide synthase (eNOS), homocysteine (Hcy), monocyte chemoattractant protein-1 (MCP-1) were determined with enzyme-linked immunosorbent assay. Results: At baseline, all clinical periodontal parameters were significantly higher in the chronic periodontitis group than in the periodontally healthy group (p<0.05). After the initial periodontal treatment, in the test group, all of the clinical periodontal parameters showed a significant decrease compared to the baseline values (p<0.05). At baseline, ADMA, Hcy and MCP-1 levels were significantly higher in the test group than in the control group (p<0.05), and after treatment ADMA and MCP-1 levels showed a significant decrease whereas eNOS level showed significant increase (p<0.05). Conclusion: It was observed that initial periodontal treatment in patients with severe chronic periodontitis has positive effects on cardiovascular risk markers.
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    Effect of Music Therapy on Dental Anxiety in Periodontal Surgery
    (Cumhuriyet University Faculty of Dentistry, 2024) Ozcan, Muhammed Furkan; Hendek, Meltem; Baris, Kubilay; Olgun, Ebru
    Introduction: Pharmacological or non-pharmacological methods are applied to eliminate fear and anxiety problems related to dental treatments in many patients. As a non-invasive, non-pharmacological method with an anxiolytic effect, music therapy is preferred in the management of anxiety and fear. This study aimed to investigate the effect of music therapy on dental anxiety in patients scheduled to undergo periodontal surgery. Material and Method: The study included a total of 46 patients, 23 in the study group and 23 in the control group, who were scheduled to undergo periodontal surgery. During the surgical procedure, the patients in the study group listened to music using in-ear headphones that isolated ambient sounds. The patients in the control group wore in-ear headphones to isolate ambient sounds, but they did not listen to any music. All patients were asked to complete the Modified Dentistry Anxiety Scale (MDAS), the State-Trait Anxiety Inventory-State (STAI-S), and the Dental Fear Survey (DFS) before and after surgery. Systolic blood pressure (SBP) and diastolic blood pressure were measured as vital signs before and after surgery, and the Visual Analog Scale (VAS) scores were recorded twice (at the end of and 30 minutes after the surgical procedure). Results: In the study group, the post-test MDAS, STAI-S, and DFS measurement values showed statistically significant decreases compared to the pre-test measurement values (P<0.001, P=0.009, and P<0.001, respectively), but there was no statistically significant difference in the control group (P=0.093, P=0.923, and P=0.460, respectively). In both the study and control groups, the post-test VAS measurement values statistically significantly decreased compared to the pre-test measurement values (P=0.002 and P=0.019, respectively). While the post-test SBP values decreased statistically significantly in the study group compared to the pre-test measurement values (P=0.020), there was no statistically significant difference in the control group (P=0.705). No statistically significant difference was found between the pre-test and post-test measurement values of the DFS scores in the study or control group (P=0.083 and P=0.160, respectively). Clinical significance: This study is the first clinical study to evaluate the effect of music on anxiety in periodontal surgery simultaneously with four different scales. Music therapy was found to be effective in reducing dental anxiety and fear during periodontal surgery. © This work is licensed under Creative Commons Attribution 4.0 International License
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    The effect of non-surgical periodontal treatment on gingival crevicular fluid periostin levels in patients with gingivitis and periodontitis
    (WILEY, 2020) Arslan, Rana; Karsiyaka Hendek, Meltem; Kisa, Ucler; Olgun, Ebru
    Objective The objective of the study was to evaluate the effect of non-surgical periodontal treatment on gingival crevicular fluid (GCF) periostin levels in patients with gingivitis (G) and periodontitis (P). Subjects and methods A total of 90 subjects, 30 patients with P, 30 with G, and 30 periodontally healthy (H) subjects were included. Patients with periodontal disease received non-surgical periodontal treatment. GCF periostin levels were assessed at baseline, at the 6th week, and the 3rd month after treatment. Results It was found that GCF periostin level was the lowest in the H group (89.31[47.12] pg/30 sec), followed by the G group (132.82[145.14] pg/30 sec), and the highest in the P group (207.75[189.45] pg/30 sec). These differences were statistically significant between H and the other groups (p < .001). After treatment, GCF periostin levels significantly decreased at the 6th week and the 3rd month in the G group, at the 3rd month in the P group compared to baseline values (p < .05). Conclusion The results of this study suggest that GCF periostin plays a role as a reliable biological marker in the pathogenesis of periodontal disease and non-surgical periodontal treatment is effective in decreasing GCF periostin levels.
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    The effect of smoking on gingival crevicular fluid peptidoglycan recognition protein-1 level following initial periodontal therapy in chronic periodontitis
    (Wiley, 2020) Karsiyaka Hendek, Meltem; Kısa, Üçler; Olgun, Ebru
    Objective To determine the effect of smoking on peptidoglycan recognition protein (PGRP)-1 levels in gingival crevicular fluid (GCF) in smokers and non-smokers with chronic periodontitis (CP) following initial periodontal therapy. Subjects and Methods A total of 40 patients with CP (20 smokers (S + CP) and 20 non-smokers (S-CP)) and 40 subjects with healthy periodontium (20 smokers (S + PH) and 20 non-smokers (S-PH)), comprising 80 subjects, were included in this study. Baseline GCF samples were obtained from all subjects, and clinical periodontal measurements were recorded. In patients who had received initial periodontal therapy, GCF samples were obtained and all clinical periodontal measurements were recorded again during the 6th-8th weeks. GCF PGRP-1 levels were analyzed by enzyme-linked immunosorbent assay. Results At baseline, GCF PGRP-1 levels were significantly higher in both groups with CP than in both groups with healthy periodontium, whereas these levels were significantly lower in S + CP than in S-CP. GCF PGRP-1 levels decreased significantly in both CP groups after periodontal therapy, and this reduction was significantly greater in non-smokers than in smokers. Conclusion Smoking might have a suppressive effect on GCF PGRP-1 levels in CP. Initial periodontal therapy is effective in decreasing GCF PGRP-1 levels in both smokers and non-smokers with CP.
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    The effect of the systemic folic acid intake as an adjunct to scaling and root planing on clinical parameters and homocysteine and C-reactive protein levels in gingival crevicular fluid of periodontitis patients: A randomized placebo-controlled clinical trial
    (WILEY, 2020) Keceli, H. Gencay; Ercan, Nuray; Karsiyaka Hendek, Meltem; Kisa, Ucler; Mesut, Burcu; Olgun, Ebru
    Aim To evaluate clinical and biochemical effects of adjunctive systemic folic acid (FA) intake with scaling and root planing (SRP) in periodontitis treatment. Materials and methods Sixty periodontitis subjects (30 per group) were randomly assigned into study groups and treated with either SRP + placebo (SRP + P) or SRP + folic acid (SRP + F). In addition to clinical parameters (plaque index [PI], gingival index [GI], probing pocket depth [PPD], clinical attachment level [CAL] and gingival recession [GR]), gingival crevicular fluid (GCF) samples were obtained at baseline and post-treatment (PT) periods (one (PT-1), three (PT-3) and six (PT-6) months) for C-reactive protein (CRP) and homocysteine (Hcy) evaluation. Results Significant time-dependent reduction was detected at all clinical parameters for both groups (p < .001). Compared to SRP + P, CAL was lower in SRP + F at PT-1 (p = .004) and PT-3 (p = .035), whereas GR was lower at only PT-1 (p = .015). GCF volume and CRP did not show inter-group differences, whereas Hcy was higher in SRP + F at PT-3 (p = .044) and PT-6 (p = .041). GCF volume and Hcy showed reduction after treatment in both groups (p < .001). Conclusion Both modalities exhibited clinical improvement and change in biochemical parameters. Adjunctive systemic FA intake may be recommended adjunctive to periodontitis treatment to reveal better outcomes. However, its impact mechanisms should be further enlightened.
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    Effect of Various Laser Systems in Smokers and Non-smokers with Peri-implantitis: A Randomized, Prospective, Single-blind Clinical Trial
    (Galenos Publ House, 2023) Barış, Kubilay; Olgun, Ebru; Badem, Nermin Dindar
    Objective: The aim of this study was to evaluate the effects of different laser systems in smokers and nonsmokers with peri-implantitis. Materials and Methods: Subjects were divided into six groups according to the study protocol: Group 1: Smokers who underwent diode laser application; group 2: Erbium, chromium: Yttrium, scandium, gallium, garnet (Er, Cr: YSGG) laser application. Group 3: smokers undergoing Erbium: Yttrium-aluminum-garnet (Er: YAG) laser application; group 4: non-smokers undergoing diode laser application; group 5: non-smokers undergoing Er,Cr: YSGG laser application; and group 6: non-smokers undergoing Er: YAG laser application. Peri-implant sulcus depth (SD), clinical attachment level (CAL), suppuration, modified plaque index (mPI), gingival index (GI), and modified sulcus bleeding index (mSBI) were recorded, and peri-implant sulcus fluid (PISF) was collected to evaluate osteocalcin. Results: There were statistically significant differences in the baseline and six-month SD, CAL, mPI, GI, mSBI measurements, and osteocalcin values in all groups (p<0.05). Conclusion: Laser applications for treating peri-implantitis have significantly improved clinical parameters and PISF osteocalcin levels.
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    Effects of D3K2 With Periodontal Therapy in Diabetes Mellitus and Stage I-II Periodontitis Patients
    (Wiley, 2024) Aydogan, Tolga; Karsiyaka Hendek, Meltem; Unsal, Berrin; Cifci, Aydin; Varol, Hakan; Kisa, Ucler; Olgun, Ebru
    Background: The aim of this study is to look into the clinical and biochemical outcomes of D3K2 supplementation in addition to nonsurgical periodontal treatment (NSPT) for patients suffering from diabetes mellitus (DM) and periodontitis. Methods: Thirty-eight participants with DM and periodontitis were randomized into two different groups. The test group provided NSPT with D3K2 whereas the control group received NSPT with placebo. Clinical periodontal parameters were recorded and serum and gingival crevicular fluid (GCF) were sampled at baseline and at the third and the sixth months after treatment. Glycated hemoglobin A1c (HbA1c), fasting blood glucose (FBG), 25(OH)D-3, parathyroid hormone (PTH), calcium (Ca) and magnesium (Mg) values were determined in blood samples. GCF and serum interleukin (IL)-1 beta and IL-10 levels were analyzed using enzyme-linked immunosorbent assay. Results: All clinical periodontal parameters were importantly decreased at the third and sixth months after treatment compared to baseline in both groups. At the sixth month, 25(OH)D-3 levels in the test group were observed to be statistically significantly higher than in the control group (p = 0.02). Serum IL-1 beta showed a statistically significant decrease at the sixth month compared to baseline and the third month in control group. Conclusion: According to this study, there is limited additional benefit of D3K2 given with NSPT in individuals with DM and periodontitis.
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    Effects of T-PRF and A-PRF on the Osteogenic Biomarkers in Intrabony Defects of Periodontitis Patients
    (Cumhuriyet University Faculty of Dentistry, 2023) Sume, S. Selva; Hendek, Meltem Karsiyaka; Kisa, Ucler; Olgun, Ebru
    Objectives: Different derivatives of platelet-rich fibrin (PRF) have been developed but the efficacy of these derivatives in tissue healing and regeneration is still unclear. The aim of this study was to evaluate the effects of titanium-prepared PRF (T-PRF) and advanced PRF (A-PRF) on osteogenic biomarkers in gingival crevicular fluid (GCF) and clinical parameters. Materials and Methods: Seventeen systemically healthy participants with 30 bilateral intrabony defects were recruited. Following phase I periodontal therapy, intrabony defects were treated either with A-PRF+open flap debridement (OFD) or T-PRF+OFD. Plaque index (PI), gingival index (GI), pocket depth (PD), clinical attachment loss (CAL) was recorded at the baseline and 6th month after treatment. GCF samples were collected at the baseline and 3rd, 6th months after surgery. Nuclear factor receptor activator (RANK), receptor activator nuclear kappa-B ligand (RANKL), osteoprotegerin (OPG) and tumor necrosis factor alpha converting enzyme (TACE) in GCF samples were analyzed by human enzyme-linked immunosorbent assay (ELISA). Results: In both groups, statistically significant changes were observed in clinical parameters, however, there was no difference between the groups. In terms of osteogenic biomarkers in GCF, there were no statistically significant differences between and within the groups. Conclusions: Different derivatives of PRF can be used to enhance the clinical outcomes of intrabony defects in periodontitis. © (2023), (Cumhuriyet University Faculty of Dentistry). All Rights Reserved.
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    Evaluation of FGF-23 and 25(OH)D-3 levels in peri-implant sulcus fluid in peri-implant health and diseases
    (Wiley, 2019) Acipinar, Sukran; Hendek, Meltem Karsiyaka; Olgun, Ebru; Kisa, Ucler
    Background There are limited studies to date investigating vitamin D and fibroblast growth factor (FGF)-23 in different peri-implant conditions. Purpose To evaluate the peri-implant sulcus fluid (PISF) FGF-23 and 25-hydroxy-vitamin D-3 (25(OH)D-3) levels in peri-implant health and diseases. Materials and Methods A total of 90 dental implant sites (peri-implant healthy group [n = 30], peri-implant mucositis group [n = 30], and peri-implantitis group [n = 30]) in 53 participants were included in the study. Probing depth (PD), clinical attachment level (CAL), suppuration (S), modified plaque index (mPI), gingival index (GI), modified sulcus bleeding index (mSBI), and keratinized mucosa width (KMW) were recorded as clinical parameters, and PISF samples were obtained. FGF-23 and 25(OH)D-3 levels were analyzed by enzyme-linked immunosorbent assay. Results There were no statistically significant differences in FGF-23 concentrations among the groups (P > .05). The 25(OH)D-3 concentration was significantly lower in peri-implantitis group compared with the other two groups (P < .05). The mean total amount of FGF-23 in the peri-implantitis group was significantly higher than the peri-implant healthy group whereas 25(OH)D-3 total amount was significantly lower in the peri-implantitis group than the peri-implant healthy group. The 25(OH)D-3 concentration was significantly negatively correlated with CAL, PD, mPI, S, GI, and mSBI and statistically significant relationship was found between FGF-23 total amount and these clinical parameters (P < .05). There was a negligible positive correlation between 25(OH)D-3 and FGF-23 concentrations (tau = 0.169; P = .018). Conclusion Within the limitations of this study, it can be concluded that FGF-23 and vitamin D seems to affect peri-implant bone health, and further studies are needed to explain the association between FGF-23 and 25(OH)D-3 in peri-implant conditions.
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    Evaluation of the Quality of Peri-implantitis Videos on YouTube
    (Lippincott Williams & Wilkins, 2023) Baris, Kubilay; Hendek, Meltem Karsiyaka; Olgun, Ebru
    Although many studies have evaluated the quality of YouTube videos related to dentistry, just one study has evaluated the quality of YouTube videos related to peri-implantitis. The aim of the cross-sectional study was to evaluate the quality of peri-implantitis-related YouTube videos. Two periodontists evaluated 47 videos that met the inclusion criteria, such as the country of upload, source of videos, number of views, likes and dislikes, viewing rate, interaction index, number of days since upload, duration of the video, usefulness score, global quality scale score, and comments. Peri-implantitis was evaluated using a 7-question system of the videos, 44.7% and 55.3% were uploaded by commercial companies and health care professionals, respectively. Although the usefulness score of the videos uploaded by health care professionals was statistically significantly higher (P=0.022), the number of views, numbers of likes and dislikes were similar between the groups (P>0.050). Although the usefulness score and global quality scale score of the perfect videos were statistically different between the groups (P<0.001; P<0.001, respectively), the number of views, numbers of likes, and dislikes were similar. A strong positive correlation was found between the number of views and the number of likes (P<0.001). A strong negative correlation was found between the interaction index and the number of days since upload (P<0.001). As a result, YouTube videos on peri-implantitis were limited in number and had poor quality. Thus, videos of perfect quality should be uploaded.
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    Periodontal Hastalık ve Antioksidan Bitkiler
    (2021) Bezirci, Didem; Hendek, Meltem Karşıyaka; Olgun, Ebru
    Periodontal hastalık, mevcut oral floranın disbiyozu nedeniyle periodonsiyumun yıkımına yol açan ilerleyici, enfeksiyöz bir enflamatuvar hastalıktır. Patojenik mikroorganizmalar, periodontal hastalığın etiyolojik faktörüdür, immüno-enflamatuvar yanıt hastalığın ilerlemesini etkilemektedir. Periodontal hastalık sırasında, reaktif oksijen türlerinin aşırı üretimi ve organizmanın dengeleme kapasitesi aşıldığında oksidatif stres oluşmaktadır. Oksidatif stres, periodonsiyumun doğrudan (biyomolekül hasarı) veya dolaylı yoldan (enflamatuvar sitokin ve yıkıcı enzimlerin üretimini arttırarak) yıkımına neden olmaktadır. Bu nedenle, reaktif oksijen türlerinin antagonisti olarak, antioksidanlar periodontal hastalıkların tedavisinde yardımcı olabilmektedir. Bitkiler, periodontal sağlığın korunmasında eşsiz rol oynayan bazı dikkat çekici faydalara ve önemli özelliklere sahiptir. Bunlar geleneksel periodontal tedavinin sonuçlarını iyileştirebilecek mükemmel yardımcılar olarak ortaya çıkmıştır. Bu derlemenin amacı, antioksidan kapasitesi ve periodontal hastalıkta potansiyeli bulunan çeşitli bitki ve bitki ürünlerinin birkaçını vurgulamaktır.
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    Periodontal Hastalık ve Kardiyovasküler Hastalıklar
    (2021) Keşir, Sıddıka Selva Süme; Hendek, Meltem Karşıyaka; Olgun, Ebru
    Periodontal ve kardiyovasküler hastalıklar, patogenezinde enflamasyonun rol oynadığı durumlardır. Yakın dönemde yapılan çalışmalar, periodontal hastalığın kardiyovasküler hastalık oluşumu ve ilerlemesi üzerine etkili olabileceğini ortaya koymuştur. Aterom lezyonlarında tespit edilen oral patojenler iki hastalık arasındaki olası ilişkiyi kuvvetlendirmektedir. İltihaplı ve ülsere dişeti epiteli yolu ile periodontal patojenlerin sistemik dolaşıma infiltrasyonu olası mekanizma olarak kabul edilmektedir. Bakteriyel infiltrasyon sonucunda vasküler dokuları etkileyen oral patojenlerin, sistemik dolaşımda ilerleyerek kardiyovasküler sistem için zararlı reaksiyonları başlattıkları düşünülmektedir. Ayrıca, ülsere dişetinden proenflamatuvar sitokin/kemokin sızıntısı akut faz proteinlerinin sentezine neden olabilir. Kronik bakteriyemi kazanılmış bağışıklık cevabını etkileyebilir. Periodontal patojenlere cevap olarak üretilen antikorlar, endotel hücreleri ve modifiye lipidler arasındaki çapraz reaksiyonları uyarabilmektedir. Bu reaksiyonların damar duvarında lipid yoğunluğunu arttırabileceği düşünülmektedir. Bunlara ek olarak, bazı antikorların ve enflamatuvar sitokinlerin T yardımcı hücre-1 cevabını uyararak aterom lezyonlarındaki makrofajların aktivasyonunu arttırdıkları savunulmaktadır. Tüm bu mekanizmaların aterogenezin başlamasına ve ilerlemesine katkıda bulunduğu düşünülmektedir. Bu derleme, periodontal hastalık ve kardiyovasküler hastalık arasındaki ilişkide olası mekanizmalara değinmektedir.
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    Platelet-rich fibrin and its use in dentistry
    (2022) Khaled, Sarah; Olgun, Ebru; Hendek, Meltem
    PRF is often defined as an autogenous fibrin biomaterial rich in leukocytes and platelets and is clinically easy to obtain and use. Various methods are available to prepare platelet concentrates, albeit the contents of platelet concentrates obtained by different methods also vary. Accordingly, they are divided into P-PRF, L-PRF, i-PRF, A-PRF, and A-PRF+, considering the thrombocyte leukocyte concentrates and fibrin contents. PRF is widely adopted in dentistry as promoting angiogenesis, immunity, and epithelial proliferation.
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    Prophylactic and therapeutic effects of (6)-shogaol on alveolar bone loss in experimental periodontitis
    (Istanbul Univ Press, Istanbul Univ Rectorate, 2024) Bezirci, Didem; Hendek, Meltem Karsiyaka; Ozcan, Gonen; Kul, Oguz; Anteplioglu, Tugce; Olgun, Ebru
    Purpose (6)-Shogaol is the most prevalent bioactive compound in ginger. The aim of this study was to examine both the prophylactic and therapeutic effects of (6)-shogaol in an experimental periodontitis model. Materials and Methods Thirty-five male Wistar albino rats were divided into four groups. In the healthy group (n=5), no intervention was undertaken. In the periodontitis group (n=10), periodontitis was induced by ligature placement for 14 days. In the prophylaxis group (n=10), periodontitis was induced with ligature placement for 14 days, and during this time, 20 mg/kg/day of (6)-shogaol was administered via oral gavage. In the therapeutic group (n=10), periodontitis was induced with ligature placement for 14 days, and following the removal of the ligature, 20 mg/kg/day of (6)-shogaol was administered via oral gavage for 14 days. Alveolar bone loss was histometrically measured, and malondialdehyde (MDA), superoxide dismutase (SOD), glutathione peroxidase (GP), nuclear factor kappa B (NF-kappa B), receptor activator of nuclear factor kappa B ligand (RANKL), and osteoprotegerin (OPG) were immunohistochemically analyzed. Results Alveolar bone loss was significantly lower in the healthy group than in the remaining groups, as well as in the therapeutic group than in the periodontitis group (p<0.001). RANKL/OPG was significantly higher in the periodontitis group compared to the remaining groups and in the prophylaxis group compared to the therapeutic group (p<0.001). MDA was significantly lower in the healthy group than in the remaining groups (p<0.001). SOD was significantly lower in the periodontitis group than in the prophylaxis and therapeutic groups (p=0.039 and p=0.042, respectively). GP was significantly lower in the healthy group than in the prophylaxis and therapeutic groups (p=0.031 and p=0.002, respectively). Conclusion The administration of (6)-shogaol modulated the RANKL/OPG balance and antioxidant status in rats with ligature-induced periodontitis.
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    Relationship between periodontal disease and vitamin D
    (2022) Aydoğan, Tolga; Hendek, Meltem Karşıyaka; Olgun, Ebru
    Vitamin D is a hormone synthesized by human skin cells or consumed through diet with immunomodulatory, anti-inflammatory, and antiproliferative effects. Vitamin D deficiency may increase the risk of periodontal disease by causing decreased bone mineral density, osteoporosis, progression of periodontal diseases, and resorption of the jawbone. In addition, vitamin D is important for bone metabolism, alveolar bone resorption, and the prevention of tooth loss. It increases the antibacterial defense of gingival epithelial cells, reduces gingival inflammation, accelerates postoperative wound healing after periodontal surgery, and is a key supplement functioning as a prophylaxis in periodontology. The present review study aims to highlight the role of vitamin D in periodontal disease.