Effects of T-PRF and A-PRF on the Osteogenic Biomarkers in Intrabony Defects of Periodontitis Patients
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Tarih
2023
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Cumhuriyet University Faculty of Dentistry
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Objectives: Different derivatives of platelet-rich fibrin (PRF) have been developed but the efficacy of these derivatives in tissue healing and regeneration is still unclear. The aim of this study was to evaluate the effects of titanium-prepared PRF (T-PRF) and advanced PRF (A-PRF) on osteogenic biomarkers in gingival crevicular fluid (GCF) and clinical parameters. Materials and Methods: Seventeen systemically healthy participants with 30 bilateral intrabony defects were recruited. Following phase I periodontal therapy, intrabony defects were treated either with A-PRF+open flap debridement (OFD) or T-PRF+OFD. Plaque index (PI), gingival index (GI), pocket depth (PD), clinical attachment loss (CAL) was recorded at the baseline and 6th month after treatment. GCF samples were collected at the baseline and 3rd, 6th months after surgery. Nuclear factor receptor activator (RANK), receptor activator nuclear kappa-B ligand (RANKL), osteoprotegerin (OPG) and tumor necrosis factor alpha converting enzyme (TACE) in GCF samples were analyzed by human enzyme-linked immunosorbent assay (ELISA). Results: In both groups, statistically significant changes were observed in clinical parameters, however, there was no difference between the groups. In terms of osteogenic biomarkers in GCF, there were no statistically significant differences between and within the groups. Conclusions: Different derivatives of PRF can be used to enhance the clinical outcomes of intrabony defects in periodontitis. © (2023), (Cumhuriyet University Faculty of Dentistry). All Rights Reserved.
Açıklama
Anahtar Kelimeler
A-PRF; Intrabony defects; osteogenic biomarkers; periodontal surgery; T-PRF
Kaynak
Cumhuriyet Dental Journal
WoS Q Değeri
Scopus Q Değeri
Q4
Cilt
26
Sayı
3
