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Öğe 0.1% Nepafenac reduces pain and increases patient comfort during cataract surgery(Elsevier, 2018) Oğurel, Tevfik; Oğurel, Reyhan; Onaran, Zafer; Ornek, KemalPurpose: To evaluates analgesic effectiveness of 0.1% nepafenac during cataract surgery. Methods: This prospective randomized randomized double-masked, placebo-controlled study comprised 80 eyes of 40 consecutive patients who underwent bilateral cataract surgery and implantation of foldable intraocular lens with topical anesthesia with and without topical nepafenac drops. Each eye of patients was assigned to group 1 and group 2. Topical anesthesia combined with 0.1% nepafenac used three times a day the day before the surgery and once half an hour just before the surgery was group 1, consisting of 40 eyes, and topical anesthesia with using placebo was group 2 consisting of 40 eyes. Patients were asked to score their pain using a visual analog scale (VAS) and verbal pain scale (VPS) immediately following the surgery. When the patient moved or squeeze the eye during surgery, the surgical comfort was evaluated as bad and otherwise, it was evaluated as good. Results: When the intensity of pain during the surgery was evaluated, the percentage of patients reporting mild or no pain in group 1 was %825 and in group 2 was %45. Mean VAS pain score and mean VPS pain score in group 1 was significantly lower than that in group 2(p = 0.024, p < 0.001). Surgical comfort in group 1 was %825 and in group 2%65(P = 0.075). Conclusion: 0.1% nepafenac reduces pain of patients who undergone routine clear corneal phacoemulsification with topical anesthesia and may increase patient comfort during the surgery when used preoperatively.Öğe Açık Glob Yaralanmaları Epidemiyolojisi(2018) Oğurel, Tevfik; Gökçınar, Nesrin Büyüktortop; Güler, Hatice Ayhan; Ölmez, Yaşar; Dikel, Nevin Hande; Onaran, ZaferAmaç: 01.01.2014 ile 01.05.2017 tarihleri arasında açık glob yaralanması nedeniyle başvuran 53 hastanın 53 gözünü epidemiyolojik açıdan retrospektif olarak incelemek. Gereç ve Yöntem: Hasta bilgileri hasta dosyaları taranarak kaydedildi. Çıkarılan hasta verileri yaş, cinsiyet, travma türü (keskin/künt), yer ve travmanın şekli ve hangi gözde olduğu şeklindeydi. Başvuru anındaki ve en son andaki görme keskinliği Snellen'in görme keskinliği çizelgesi kullanılarak kaydedildi. Dilate fundus bulgularını da kapsayan biyomikroskobik muayeneler ayrıntılı olarak not edildi. Bulgular: Hastaların 43’ü (%81,1) erkek, 10’u (%18,9) kadındı. Cinsiyet açısından karşılaştırıldığında açık glob travması erkek hastalarda kadın hastalara göre istatistiksel olarak daha yüksekti (p0.001). Hastaların yaşı arttıkça açık glob yaralanması insidansının azaldığı görüldü. Travmaların %54,7’si iş kazası, %22,6’sı ev kazası, %7,5’i trafik kazası, %13,2’si ev ve iş dışında, %1,9’u ise spor yaparken gerçekleşen kazalardı. Sonuç: Açık glob yaralanmalarının tedavi sonuçları hastalar için yüz güldürücü değildir ve bu tip yaralanmaların çoğunluğu önlenebilir sebeplerden meydana gelmektedir. İş güvenliğine verilecek önem ve toplumun bu konudaki farkındalığını arttıracak eğitimler bu tür yaralanmaların oranını azaltabilir.Öğe An Adolescent Girl with an Extraordinary Crohn Disease(Springer, 2019) Gulerman, Fulya; Guven, Burcu; Celik, Cansu; Onaran, Zafer; Celikel, Banu AcarInflammatory bowel disease (IBD) is a comprehensive term used to describe diseases of the gastrointestinal tract resulting from chronic inflammatory processes. Patients with Crohn`s disease, a type of IBD, also may have extraintestinal findings. Joint symptoms and mucocutaneous involvement are the most common manifestations. Therefore, the presence of symptoms such as swollen, painful joints, aphthous stomatitis, erythema nodosum, uveitis, and pericarditis should not be avoided. A 15-year-old girl was admitted to our outpatient clinic with complaints of severe abdominal pain, nausea, vomiting and bleeding in one eye. The patient was diagnosed with acute pancreatitis and uveitis at the first evaluation, followed by bloody diarrhea and arthritis. In endoscopy, antrum, bulbus and second segment of duodenum were seen as hyperemic, nodular and edematous. In the colonoscopy, mucosa of the terminal ileum was granular and edematous. The cecum, the ascending colon, hepatic flexure, descending colon, sigmoid colon, and rectum mucosa were hyperemic, granular in appearance (cobblestone view) and lymphoid hyperplasic in appearance. The patient was diagnosed as multisystemic Crohn`s disease. The patient was followed up with prednisolone and mesalazine treatment. At the end of one-year follow-up, the symptoms of pancreatitis improved totally, but there were no response to the treatment for uveitis and arthritis, and patient developed pericarditis and bloody diarrhea continued occasionally. Infliximab, a biological agent (tumour necrotising factor alpha, TNFa blocker), was the second choice of treatment. The expected result could not be obtained and after 6 cure treatments medication was switched to adalimumab. After 6 cycles of treatment, the patient`s symptoms were completely regressed. In conclusion, it should be kept in mind that extraintestinal manifestations of IBD can occur in pediatric patients before the original signs of the disease occur. The management of these findings with new treatment modalities may result in more positive outcomes in the future.Öğe Agreement and repeatability of central corneal thickness measurements by four different optical devices and an ultrasound pachymeter(Springer, 2019) Gokcinar, Nesrin Buyuktortop; Yumusak, Erhan; Ornek, Nurgul; Yorubulut, Serap; Onaran, ZaferPurpose To compare the repeatability and agreement of central corneal thickness (CCT) measurements by spectral-domain optical coherence tomography (OCT), corneal topography (CT) with a combined Scheimpflug-Placido system, optical biometry (OB), specular microscopy (SM), and ultrasound pachymetry (UP). Methods A single observer measured CCT twice in 150 eyes of 150 subjects with each of five devices: Nidek RS-3000 Advance OCT, CSO Sirius combined Scheimpflug-Placido disc system CT, Nidek AL-Scan partial coherence interferometry-based OB, Tomey EM-3000 SM, and Reichert iPac ultrasonic pachymeter. Pachymetry values corrected by the SM device software were also recorded. Levels of agreement between devices were evaluated by Bland-Altman plots with 95% limits of agreement, and repeatability for each device was analysed with intraclass correlation coefficients. Results The mean CCTs measured by OCT, CT, OB, SM, corrected SM, and UP were 544.60 +/- 29.56, 536.19 +/- 32.14, 528.29 +/- 29.45, 524.88 +/- 32.38, 537.88 +/- 32.38, and 545.29 +/- 30.75 mu m, respectively. Mean CCT differed significantly between the devices (p<0.05) apart from between OCT and UP, and between CT and corrected SM. Mean paired differences between devices ranged between 0.68 and 20.41 mu m. Repeatability with all devices was excellent (>0.99). The range of limits of agreement was the least between OCT and UP. Conclusions Different CCT measurement techniques produce quite different results, so CCT evaluation and follow-up should be performed using the same device or devices with close compatibility.Öğe Antiglokomatöz Tedavi Alan Hastalar Gerçekten Glokom Hastası mı?(2017) Onaran, Zafer; Oğurel, Reyhan; Oğurel, TevfikAmaç: Glokom olmadığı halde glokom tanısı konularak yıllardır göz tansiyonu damlası kullanmak zorunda kalan hastalara nasıl tanı konduğu, hangi ilaçları kaç yıl süreyle kullandığı ve bu ilaçların hasta üzerinde olan etkileri araştırıldı.Gereç ve Yöntemler: Çalışma retrospektif olarak kullandığı glokom ilacını tekrar reçete etmeye ya da raporu bittiği için raporunu yenilemeye gelen hastalar ile glokomu olduğunu söyleyip kontrole gelen hastalar arasında yapıldı. Tüm hastalar glokomu olmayan, oküler hipertansiyonu olan ve gerçekten glokomu olan hastalar olarak 3 guruba ayrıldı. Bu hastalara rutin göz muayenesinden sonra santral kornea kalınlığı(SKK) ölçümleri, görme alanı testi ve sinir lifi analizleri yapıldı. Muayene sonrası hastalara hangi ilaçları kaç yıldır kullandıkları, yöntemler tarif edilerek hangi yöntemle göz içi basıncı (GİB) ölçüldüğü, SKK'nın ölçülüp ölçülmediği, daha önce görme alanı testi ve düzenli kontrol yaptırıp yaptırmadıkları soruldu. Hastalardan ilaçlarını kesmeleri istenerek 2 hafta sonra GİB takibine çağrıldı.Bulgular: Tüm hastalar değerlendirildiğinde hastaların yalnız %7.1'inde (8/113) gerçekten glokom mevcuttu. Hastaların ilaç kullanım süreleri ortalama 3.84±1.24 yıldı. Hastaların ortalama SKK sağlıklı gurupta 583.51±27.55 ?, oküler hipertansiyonu olan gurupta 558.12±36.80 ?ve glokomu olan hastalarda 552±23.10? idi. Hastaların yalnız 12'si(%10.6) daha önce tansiyonlarının aplanasyon tonometrisi ile ölçüldüğünü ifade etti, geri kalan tamamında ölçümler non-kontak tonometri ile yapılmıştı. Sonuç: Günlük uygulamada glokomun yanlış teşhisi yaygın bir konudur, glokom hastaları glokom kriterleri açıkça karşılanmadığında yeniden değerlendirilmelidirÖğe Autologous serum effect on corneal endothelial damage in the phacoemulsification rabbit model(Derman Medical Publ, 2017) Usta, Gülşah; Oğurel, Reyhan; Onaran, Zafer; Pekcan, Zeynep; Oğurel, Tevfik; Karsli, Birkan; Gökçinar, Nesrin BüyüktortopAim: This study used specular microscopy to evaluate the possible effects of applying autologous serum to the anterior chamber on the corneal endothelial damage created by the ultrasonic vibrations of phacoemulsification (PHACO) in rabbits. Material and Method: The study, which was approved by the Ethics Committee, involved both eyes of nine 5 month-old (about 3 kg) New Zealand genus albino male rabbits. Group 1(6 eyes) received only an application of 0.2 ml autologous serum; Group 2 (6 eyes) received only the ultrasonic vibrations for 20 seconds: and Group 3 (6 eyes) received 0.2 ml autologous serum followed by ultrasonic vibrations for 20 seconds. Measurements were made before the intervention and at the 1st and 7th days postoperatively using specular microscopy, intraocular pressure, and pachymetry metrics, and the data were compared statistically. Results: Postoperative 1st week, the cornea thickness increased from 385 mu to 445 mu in Group 2 (PHACO only) and from 398 mu to 402 mu in Group 2 (PHACO plus autologous serum). However, this difference was not statistically significant. Postoperative 1st day standard deviation (p < 0.05) and variation coefficient (p < 0.05) values of the specular microscopy parameters for Groups 2 and 3 were higher than for Group 1. Postoperative 1st week it was observed that the parameters of the three groups were similar and had returned to the preoperational values. Between the endothelial cell numbers, the cell density, the cell space average, the largest and the smallest percentage of the cell and the hexagonal cell area values, there were no statistically significant differences at the three measurement time points. Discussion: This study showed that, after the phacoemulsification process, autologous serum applied to the anterior chamber can, by positive possible effects on endothelial pump functions, reduce corneal edema without morphological changes, which can be confirmed with specular microscopyÖğe Bilateral non-arteritic anterior ischemic optic neuropathy following second-trimester spontaneous abortion-related haemorrhage(Elsevier Sci Ltd, 2012) Onaran, Zafer; Tan, Funda Uysal; Yilmazbas, Pelin; Onaran, YükselBilateral anterior ischemic optic neuropathy is a rare complication of massive haemorrhage and related hypotension and anaemia in young individuals. We report a 34-year-old woman with bilateral non-arteritic ischemic optic neuropathy (NAION) after a massive spontaneous abortion-related haemorrhage who presented with sudden painless visual loss in her left eye. Visual acuity was 20/20 in the right eye with only hand motion discernible in the left eye. There was a left relative afferent papillary defect (RAPD). Fundus examination revealed bilateral swollen, hyperaemic optic discs and nerve fiber layer haemorrhages. Brain MRI and magnetic resonance venography were normal. The diagnosis of bilateral NAION was made and intravenous pulse corticosteroid therapy (1000 mg/day) was administered for three days. On the sixth clay, optic disc oedema regressed bilaterally and on the third week, the visual acuity improved to 20/80 in the left eye. The visual field showed only a small spared area in the nasal region, and persistent RAPD was present. After two months, fundus examination showed a small and crowded optic disc on the right and a pale optic disc on the left. Severe acute haemorrhage is an important risk factor for NAION in healthy young individuals. In addition to correction of hypotension and anaemia, intravenous high dose corticosteroid might be beneficial for treatment. (C) 2012 Elsevier Ltd. All rights reserved.Öğe Bilateral punctum atresia and lacrimal sac fistula in a child with CHARGE syndrome(Wiley-Blackwell Publishing, Inc, 2009) Onaran, Zafer; Yimazbaş, Pelin; Örnek, Kemal…Öğe Bir olgu nedeniyle sinüzit komplikasyonu sonucu gelişen subperiostal orbita apsesinin endoskopik tedavisi(2009) Onaran, Zafer; Yılmazbaş, Pelin; Arıkan, Osman Kürşat; Ergin, AhmetAmaç: Akut sinüzit komplikasyonu olarak gelişen subperiostal orbita apselerinin tanı ve tedavisinin vurgulanması amaçlanmıştır. Yöntem: 9 yaşında erkek hasta üç gündür olan sol gözde ağrı ve şişlik şikayetleri ile kliniğimize başvurdu. Muayenede proptozis, kemozis, kapaklarda ödem ve göz hareketlerinde kısıtlılık saptanması üzerine orbital selülit tanısıyla yapılan manyetik rezonans görüntülemede sol paranazal sinüzite ek olarak subperiostal orbita apsesi tespit edildi. Sonuç: Tıbbi tedaviye cevap alınamaması üzerine endoskopik sinüs cerrahisi ile birlikte uygulanan apse drenajı ile hasta başarıyla tedavi edildi. Tartışma: Cerrahinin endike olduğu subperiostal orbita apselerinde endoskopik yaklaşım ilk seçenek olarak değerlendirilmelidir.Öğe Branch Retinal Artery Occlusion following Dental Extraction(Hindawi Ltd, 2014) Oğurel, Tevfik; Onaran, Zafer; Oğurel, Reyhan; Örnek, Nurgül; Büyüktortop Gökçınar, Nesrin; Örnek, KemalAim. To describe a case of branch retinal artery occlusion following dental extraction and to point out the ophthalmic complications of dental procedures to ophthalmologists and dentists. Case. A 51-year-old woman was referred to our clinic with painless sudden visual loss in her left eye after tooth extraction two days ago. In her left eye the best corrected visual acuity was 6/30 and fundus examination revealed peripapillary flame-shaped hemorrhages and pale retina in the upper temporal arcuate. The right eye examination was unremarkable. Conclusion. Dental procedures can lead to miscellaneous ophthalmic complications possibly due to the close proximity of the anatomic structures. Retinal arterial occlusion is a rare but serious cause of permanent visual loss among these dental procedures where the exact pathologic mechanism is still obscure.Öğe Central serous chorioretinopathy probably associated with isotretinoin in a keratoconus patient(Canadian Ophthal Soc, 2018) Buyuktortop, Nesrin; Onaran, Zafer; Ozkal, Fatma; Yumusak, Erhan; Karabulut, Ayse Anil…Öğe Çocukluk çağı glob yaralanmalarının epidemiyolojisi(2019) Oğurel, Tevfik; Oğurel, Reyhan; Onaran, Zafer; Örnek, Nurgül; Yumuşak, Erhan; Ölmez, YaşarAmaç: Kliniğimize glob yaralanması nedeniyle başvuran çocukların epidemiyolojik ve klinik özellikleri ile tedavi sonuçlarını değerlendirmek.Gereç ve Yöntemler: Bu retrospektif çalışmaya 01.01.2014 ile 01.07.2017 tarihleri arasında glob yaralanması nedeniyle başvuran 0-16 yaş arası 57 hastanın 57 gözü dahil edildi. Hastalar yaş, cinsiyet, travma nedeni, travma şekli (açık/kapalı) ve yeri, uygulanan tedavi ve görme keskinlikleri açısından değerlendirildi.Bulgular: Çalışmaya dâhil edilen 57 çocuğun 37’si (%64,9) erkek, 20’si (%35,1) kız çocuğuydu. Çocukların yaş ortalaması 7,63±4,27 yıl (1-16) idi. Çocuklar 0-5 yaş (bebek ve okul öncesi), 6-10 yaş (ilköğretim) ve 11-16 yaş (ortaöğretim) olmak üzere üç yaş grubuna ayrıldı. En fazla yaralanma vakası %42,1 (n=24) oranı ile 6-10 yaş grubundaki çocuklar arasında idi. Bunu 0-5 yaşları arasındaki (%33,3, n=19) ve 11-16 yaşları arasındaki (%24,6, n=14) çocuklar izledi. Tüm yaş grupları karşılaştırıldığında travmaya maruz kalan erkek sayısı kızlardan istatistiksel olarak anlamlı derecede yüksekti (p=0,02). Hastaların 26’sı (%45,6) açık, 31’i (%54,4) kapalı glob yaralanması ile hastanemize başvurmuştu.Sonuç: Çoğu göz yaralanması basit tedbirlerle önlenebilirken, travmaya maruz kalan çoğu çocuk psikososyal gelişimlerini ciddi şekilde engelleyebilecek görme bozukluğu yaşayabilmektedir. Basit, koruyucu tedbirler uygulandığı takdirde kazaların büyük bir kısmının önlenebileceği bilinmelidir.Öğe The comparison of the relationships about the presence of branch retinal vein occlusion and endothelial functions between diabetic and non-diabetic patients(Lippincott Williams & Wilkins, 2019) Demir, Vahit; Dogru, Mehmet Tolga; Onaran, Zafer; Kandemir, Huseyin; Alp, CaglarObjectives The aim of this study was to investigate the endothelial functions in both patients with diabetics and non-diabetics with branch retinal vein occlusion by using pulse wave analysis and flow-mediated dilatation methods. Patients and methods This cross-sectional study included a total of 136 participants (47 diabetic patients with branch retinal vein occlusion, 43 non-diabetic patients with branch retinal vein occlusion, and 46 otherwise healthy subjects). Evaluation of endothelial functions was performed by flow-mediated dilatation and pulse wave analysis methods. Stiffness index, reflection index (RI), and pulse propagation time were calculated. Results The mean stiffness index and RI were significantly higher in the diabetic branch retinal vein occlusion group compared with the non-diabetic branch retinal vein occlusion and the healthy controls (for stiffness index: 11.5 +/- 2.8 vs. 10.1 +/- 2.5 and 8.3 +/- 2.0, P < 0.001; and for RI: 75.1 +/- 11.7 vs. 65.4 +/- 8.4 and 60.2 +/- 18.8, P < 0.001, respectively), whereas the pulse propagation time was significantly lower in the diabetic group (156.4 +/- 32.3 vs. 174.4 +/- 46.5 and 205.0 +/- 58.5, P < 0.001, respectively). There was a significant negative correlation between visual acuity and stiffness index (r = -0.512, P < 0.001). Besides, there was also a significant positive correlation between visual acuity and pulse propagation time (r = 0.398, P < 0.001). Conclusion This study demonstrated that the stiffness index and RI values were higher in patients with branch retinal vein occlusion compared to the healthy subjects. Copyright (C) 2019 Wolters Kluwer Health, Inc. All rights reserved.Öğe Corneal and conjunctival sensitivity in rosacea patients(Elsevier Science Bv, 2016) Ornek, Nurgul; Karabulut, Ayse Anil; Ornek, Kemal; Onaran, Zafer; Usta, GulsahPurpose: To assess corneal and conjunctival sensitivity in rosacea patients. Methods: A total of 55 patients with rosacea and 37 control subjects participated in the study. Corneal and conjunctival sensitivity was determined by Cochet-Bonnet esthesiometer. Subjective symptoms of ocular dryness were evaluated using Ocular Surface Disease Index (OSDI). Schirmer's I test (ST), tear breakup time (tBUT) and ocular surface staining with fluorescein were carried out to measure objective signs. Results: The mean corneal and conjunctival sensitivity did not differ significantly between rosacea patients and controls (all p > 0.05). Schirmer's I test and tBUT were significantly reduced (p = 0.004 for OD and p < 0.001 for OS) and grade of ocular surface staining was significantly high (p = 0.018 for OD and p = 0.038 for OS) in rosacea patients. Corneal and conjunctival sensitivity did not show significant correlation with ST, tBUT, ocular surface staining (Oxford Schema), duration of rosacea and OSDI score. Conclusions: Corneal and conjunctival sensitivity did not change significantly in rosacea.Öğe Corneal thickness and endothelial changes in long-term hydroxychloroquine use(Taylor & Francis Ltd, 2019) Oğurel, Tevfik; Özer, Murat Atabey; Akbulut, Yaprak; Gökçınar, Nesrin Büyüktortop; Onaran, Zafer; Üreten, KemalObjective: To determine possible associations between long-term HCQ use and corneal changes in patients who used HCQ for at least 3 years. Materials and methods: The study included 62 healthy controls and 62 consecutive patients who used HCQ for the treatment of rheumatologic disease and were referred to the ophthalmology department between August 2018 and November 2018 for HCQ retinal toxicity screening. Central corneal thickness (CCT), corneal endothelial cell density (ECD), the coefficient of variation (CV) of cell size, and the percentage of hexagonal cells (HEX%) were measured to evaluate changes in the cornea. Results: The mean age of the patient group and control group was 50.10 +/- 10.91 and 50.53 +/- 10.67 years, respectively. The mean ECD was 2742 +/- 347 (cells/mm(2)) in the patient group and 2875 +/- 188 cells/mm(2) in the control group. There was a significant difference between groups (p = 0.01). The mean CCT was 567.05 +/- 32.35 mu m in the patient group and 540.15 +/- 38.50 mu m in the control group. CCT was significantly higher in the patient group compared with control group (p < 0.001). There was no significant difference between groups in terms of mean CV and HEX values (p > 0.05). Conclusions: Patients using long-term HCQ demonstrated lower ECD and higher CCT than the control group. However, the CV of cell sizes and the HEX % values were not significantly different from the controls.Öğe Decreased choroidal thickness in vitiligo patients(Bmc, 2018) Demirkan, Serkan; Onaran, Zafer; Samav, Guzin; Ozkal, Fatma; Yumusak, Erhan; Gunduz, Ozgur; Karabulut, AyseBackground: Vitiligo is a disease characterized by depigmented macules and patches that occur as a result of the loss of functional melanocytes from the affected skin through a mechanism which has not been elucidated yet. Destruction of pigment cells in vitiligo may not remain limited to the skin; the eyelashes, iris, ciliary body, choroid, retinal pigment epithelium and meninges may also be affected. This study aims to compare the choroidal thickness of patients with and without vitiligo using optical coherence tomography (OCT). Methods: Spectral-domain optical coherence tomography (SD-OCT) (Retina Scan Advanced RS-3000 NIDEK, Japan) instrument (with lambda = 840 nm, 27,000 A-scans/second and 5 mu m axial resolution) was used for the imaging. Statistical analysis was performed using SPSS 21.0 software package. Results: In all values except optic nevre area measurements, the choroidal thickness of all vitiligo patients was found out to be thinner compared to the control group. Conclusions: In vitiligo, the choroidal thickness may be affected by the loss of melanocytes.Öğe Doğumsal persistan pupiller membranın Nd:Yag lazer ile tedavisi(2011) Onaran, Zafer; Örnek, Kemal; Yılmazbaş, PelinPersistan pupiller membran (PPM) pupiller aralığı örterek görme problemlerine yol açabilen gelişimsel bir ön segment anomalisidir. PPM tedavisinde midriazis ve kapama tedavisini içeren konservatif yaklaşımın yanında cerrahi ve Nd:YAG lazer tedavileri uygulanmaktadır. Bu yazıda 25 yaşında bir hastada Nd:YAG lazer ile tedavi edilen bilateral PPM olgusu sunulmaktadırÖğe Effect of 1% brinzolamide and 0.5% timolol fixed combination on intraocular pressure after cataract surgery with phacoemulsification(Ijo Press, 2013) Örnek, Kemal; Büyüktortop, Nesrin; Örnek, Nurgül; Oğurel, Reyhan; Erbahçeci, İnci Elif; Onaran, ZaferAIM: To evaluate the effect of brinzolamide-timolol fixed combination on intraocular pressure (IOP) after cataract surgery. METHODS: The study included 92 eyes of 87 patients who underwent cataract surgery and intraocular lens implantation. Patients scheduled for phacoemulsification were assigned to 1 of 2 groups. The treatment group received 1 drop of brinzolamide-timolol fixed combination immediately after surgery, and the control group received no treatment. The IOP was measured preoperatively and at 2h and 24h postoperatively. RESULTS: The mean IOP change was lower in the treatment group than in the control group at 2h postoperatively. The difference between the mean IOP values of the two groups at 2h postoperatively was found to be statistically significant. Twenty-four hours after the surgery, the mean IOP change was still higher in the control group when compared to the treatment group. CONCLUSION: The fixed combination brinzolamide timolol can effectively reduce IOP after cataract surgery.Öğe Effect of dexamethasone intravitreal implant (Ozurdex (R)) on corneal endothelium in retinal vein occlusion patients Corneal endothelium after dexamethasone implant injection(Bmc, 2018) Güler, Hatice Ayhan; Örnek, Nurgül; Örnek, Kemal; Gökçınar, Nesrin Büyüktortop; Oğurel, Tevfik; Yumuşak, Mehmet Erhan; Onaran, ZaferBackground: To assess corneal endothelial cell changes after intravitreal dexamethasone (DEX) implant (Ozurdex (R)) injection in patients with macular edema secondary to retinal vein occlusion (RVO). Methods: Twenty-two eyes of 22 patients were assessed prospectively after intravitreal 0.7 mg DEX implant injection. Twenty-two eyes of 22 healthy volunteers served as control group. Corneal endothelial cell parameters including endothelial cell density (ECD), coefficient of variation of cell size (CV), percentage of hexagonality (Hex) and central corneal thickness (CCT) were analyzed before and 1 and 3 months after injection by specular microscopy. The results of the study were compared statistically. Results: There were 17 (77.3%) patients with branch RVO and 5 (22.7%) patients with central RVO. Mean intraocular pressure (IOP) was 14.73 mmHg before injection, 17.05 mmHg at 1 month and 17.15 mmHg at 3 months after injection. Mean IOP at 1 and 3 months were significantly higher than pre-injection value (p = 0.002 and p = 0.003, respectively). There was a statistically significant reduction in mean ECD at 3 months after injection compared to pre-injection and 1 month (p = 0.013, p = 0.009, respectively) in the injected eyes. Mean ECD showed no significant difference in the uninjected fellow eyes during the follow up (p>0.05). Mean CV and Hex did not reveal a statistically significant difference in injected and uninjected fellow eyes (p > 0.05). No significant change was observed in mean CCT values during the follow up (p = 0.8). Conclusion: Intravitreal dexamethasone implant may cause a transient reduction in corneal endothelial cell density in short term without changing cell morphology.Öğe Elevated Tear Human Neutrophil Peptides 1-3, Human Beta Defensin-2 Levels and Conjunctival Cathelicidin LL-37 Gene Expression in Ocular Rosacea(Taylor & Francis Inc, 2019) Gokcinar, Nesrin Buyuktortop; Karabulut, Ayse Anil; Onaran, Zafer; Yumusak, Erhan; Yildiran, Fatma Azize BudakPurpose: To investigate the role of innate immunity in ocular rosacea. Methods: Thirty-two patients with ocular rosacea patients (group-1) and 28 healthy volunteers (group-2) who served as controls were enrolled in the study. Tear function parameters were assessed, conjunctival impression cytology was performed and tear samples were collected. Human-neutrophil-peptides (HNP) 1?3 and human-beta-defensin-2 (hBD-2) levels were measured in tears by using ELISA tests. Cathelicidin leucin-leucin-37 (LL-37), hBD-2, human-beta-defensin-9 (hBD-9) gene expression levels were measured in the conjunctival impression cytology samples using real-time polymerase chain reaction. Results: Tear HNP1-3 (p?=?0.024), hBD-2 (p?
