Effect of dexamethasone intravitreal implant (Ozurdex (R)) on corneal endothelium in retinal vein occlusion patients Corneal endothelium after dexamethasone implant injection
Yükleniyor...
Tarih
2018
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Bmc
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Background: To assess corneal endothelial cell changes after intravitreal dexamethasone (DEX) implant (Ozurdex (R)) injection in patients with macular edema secondary to retinal vein occlusion (RVO). Methods: Twenty-two eyes of 22 patients were assessed prospectively after intravitreal 0.7 mg DEX implant injection. Twenty-two eyes of 22 healthy volunteers served as control group. Corneal endothelial cell parameters including endothelial cell density (ECD), coefficient of variation of cell size (CV), percentage of hexagonality (Hex) and central corneal thickness (CCT) were analyzed before and 1 and 3 months after injection by specular microscopy. The results of the study were compared statistically. Results: There were 17 (77.3%) patients with branch RVO and 5 (22.7%) patients with central RVO. Mean intraocular pressure (IOP) was 14.73 mmHg before injection, 17.05 mmHg at 1 month and 17.15 mmHg at 3 months after injection. Mean IOP at 1 and 3 months were significantly higher than pre-injection value (p = 0.002 and p = 0.003, respectively). There was a statistically significant reduction in mean ECD at 3 months after injection compared to pre-injection and 1 month (p = 0.013, p = 0.009, respectively) in the injected eyes. Mean ECD showed no significant difference in the uninjected fellow eyes during the follow up (p>0.05). Mean CV and Hex did not reveal a statistically significant difference in injected and uninjected fellow eyes (p > 0.05). No significant change was observed in mean CCT values during the follow up (p = 0.8). Conclusion: Intravitreal dexamethasone implant may cause a transient reduction in corneal endothelial cell density in short term without changing cell morphology.
Açıklama
Ornek, Nurgul/0000-0003-3068-1831; Gokcinar, Nesrin Buyuktortop/0000-0001-7795-5188;
Anahtar Kelimeler
Dexamethasone implant, Retinal vein occlusion, Corneal endothelium, Specular microscopy
Kaynak
Bmc Ophthalmology
WoS Q Değeri
Q3
Scopus Q Değeri
Q2
Cilt
18
Sayı
Künye
Güler, H.A., Örnek, N., Örnek, K. et al. Effect of dexamethasone intravitreal implant (Ozurdex®) on corneal endothelium in retinal vein occlusion patients. BMC Ophthalmol 18, 235 (2018).
