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    Cytotoxicity and DNA interactions of some platinum(II) complexes with substituted benzimidazole ligands
    (Informa Healthcare, 2012) Ozcelik, Azime Berna; Utku, Semra; Gumus, Fatma; Keskin, Ayten Celebi; Acik, Leyla; Yilmaz, Sukran; Ozgungor, Adeviye
    In the present study, four Pt(II) complexes with 2-ethyl (1)/or benzyl (2)/or p-chlorobenzyl (3)/or 2-phenoxymethyl (4) benzimidazole carrier ligands were evaluated for their in vitro cytotoxic activities against the human HeLa cervix, oestrogen receptor-positive MCF-7 breast, and oestrogen receptor-negative MDA-MB 231 breast cancer cell lines. The plasmid DNA interactions and inhibition of the BamHI restriction enzyme activities of the complexes were also studied. Complex 3 was found to be more active than carboplatin for all examined cell lines and comparable with cisplatin, except for the HeLa cell line.