Cytotoxicity and DNA interactions of some platinum(II) complexes with substituted benzimidazole ligands
Yükleniyor...
Tarih
2012
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Informa Healthcare
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
In the present study, four Pt(II) complexes with 2-ethyl (1)/or benzyl (2)/or p-chlorobenzyl (3)/or 2-phenoxymethyl (4) benzimidazole carrier ligands were evaluated for their in vitro cytotoxic activities against the human HeLa cervix, oestrogen receptor-positive MCF-7 breast, and oestrogen receptor-negative MDA-MB 231 breast cancer cell lines. The plasmid DNA interactions and inhibition of the BamHI restriction enzyme activities of the complexes were also studied. Complex 3 was found to be more active than carboplatin for all examined cell lines and comparable with cisplatin, except for the HeLa cell line.
Açıklama
UTKU, Semra/0000-0003-3181-9134
Anahtar Kelimeler
Benzimidazole, platinum(II) complexes, cytotoxic activity, DNA binding, gel electrophoresis
Kaynak
Journal Of Enzyme Inhibition And Medicinal Chemistry
WoS Q Değeri
Q4
Scopus Q Değeri
Q1
Cilt
27
Sayı
3
Künye
closedAccess
