Cytotoxicity and DNA interactions of some platinum(II) complexes with substituted benzimidazole ligands
dc.contributor.author | Ozcelik, Azime Berna | |
dc.contributor.author | Utku, Semra | |
dc.contributor.author | Gumus, Fatma | |
dc.contributor.author | Keskin, Ayten Celebi | |
dc.contributor.author | Acik, Leyla | |
dc.contributor.author | Yilmaz, Sukran | |
dc.contributor.author | Ozgungor, Adeviye | |
dc.date.accessioned | 2020-06-25T18:06:35Z | |
dc.date.available | 2020-06-25T18:06:35Z | |
dc.date.issued | 2012 | |
dc.department | Kırıkkale Üniversitesi | |
dc.description | UTKU, Semra/0000-0003-3181-9134 | |
dc.description.abstract | In the present study, four Pt(II) complexes with 2-ethyl (1)/or benzyl (2)/or p-chlorobenzyl (3)/or 2-phenoxymethyl (4) benzimidazole carrier ligands were evaluated for their in vitro cytotoxic activities against the human HeLa cervix, oestrogen receptor-positive MCF-7 breast, and oestrogen receptor-negative MDA-MB 231 breast cancer cell lines. The plasmid DNA interactions and inhibition of the BamHI restriction enzyme activities of the complexes were also studied. Complex 3 was found to be more active than carboplatin for all examined cell lines and comparable with cisplatin, except for the HeLa cell line. | en_US |
dc.description.sponsorship | Research Foundation of Gazi UniversityGazi University [02/2007-16] | en_US |
dc.description.sponsorship | We would like to thank the Research Foundation of Gazi University (02/2007-16) for financial support. | en_US |
dc.identifier.citation | closedAccess | en_US |
dc.identifier.doi | 10.3109/14756366.2011.594046 | |
dc.identifier.endpage | 418 | en_US |
dc.identifier.issn | 1475-6366 | |
dc.identifier.issue | 3 | en_US |
dc.identifier.pmid | 22299582 | |
dc.identifier.scopus | 2-s2.0-84860366858 | |
dc.identifier.scopusquality | Q1 | |
dc.identifier.startpage | 413 | en_US |
dc.identifier.uri | https://doi.org/10.3109/14756366.2011.594046 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12587/5265 | |
dc.identifier.volume | 27 | en_US |
dc.identifier.wos | WOS:000303330100012 | |
dc.identifier.wosquality | Q4 | |
dc.indekslendigikaynak | Web of Science | |
dc.indekslendigikaynak | Scopus | |
dc.indekslendigikaynak | PubMed | |
dc.language.iso | en | |
dc.publisher | Informa Healthcare | en_US |
dc.relation.ispartof | Journal Of Enzyme Inhibition And Medicinal Chemistry | |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | Benzimidazole | en_US |
dc.subject | platinum(II) complexes | en_US |
dc.subject | cytotoxic activity | en_US |
dc.subject | DNA binding | en_US |
dc.subject | gel electrophoresis | en_US |
dc.title | Cytotoxicity and DNA interactions of some platinum(II) complexes with substituted benzimidazole ligands | en_US |
dc.type | Article |
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