Cytotoxicity and DNA interactions of some platinum(II) complexes with substituted benzimidazole ligands

dc.contributor.authorOzcelik, Azime Berna
dc.contributor.authorUtku, Semra
dc.contributor.authorGumus, Fatma
dc.contributor.authorKeskin, Ayten Celebi
dc.contributor.authorAcik, Leyla
dc.contributor.authorYilmaz, Sukran
dc.contributor.authorOzgungor, Adeviye
dc.date.accessioned2020-06-25T18:06:35Z
dc.date.available2020-06-25T18:06:35Z
dc.date.issued2012
dc.departmentKırıkkale Üniversitesi
dc.descriptionUTKU, Semra/0000-0003-3181-9134
dc.description.abstractIn the present study, four Pt(II) complexes with 2-ethyl (1)/or benzyl (2)/or p-chlorobenzyl (3)/or 2-phenoxymethyl (4) benzimidazole carrier ligands were evaluated for their in vitro cytotoxic activities against the human HeLa cervix, oestrogen receptor-positive MCF-7 breast, and oestrogen receptor-negative MDA-MB 231 breast cancer cell lines. The plasmid DNA interactions and inhibition of the BamHI restriction enzyme activities of the complexes were also studied. Complex 3 was found to be more active than carboplatin for all examined cell lines and comparable with cisplatin, except for the HeLa cell line.en_US
dc.description.sponsorshipResearch Foundation of Gazi UniversityGazi University [02/2007-16]en_US
dc.description.sponsorshipWe would like to thank the Research Foundation of Gazi University (02/2007-16) for financial support.en_US
dc.identifier.citationclosedAccessen_US
dc.identifier.doi10.3109/14756366.2011.594046
dc.identifier.endpage418en_US
dc.identifier.issn1475-6366
dc.identifier.issue3en_US
dc.identifier.pmid22299582
dc.identifier.scopus2-s2.0-84860366858
dc.identifier.scopusqualityQ1
dc.identifier.startpage413en_US
dc.identifier.urihttps://doi.org/10.3109/14756366.2011.594046
dc.identifier.urihttps://hdl.handle.net/20.500.12587/5265
dc.identifier.volume27en_US
dc.identifier.wosWOS:000303330100012
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherInforma Healthcareen_US
dc.relation.ispartofJournal Of Enzyme Inhibition And Medicinal Chemistry
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBenzimidazoleen_US
dc.subjectplatinum(II) complexesen_US
dc.subjectcytotoxic activityen_US
dc.subjectDNA bindingen_US
dc.subjectgel electrophoresisen_US
dc.titleCytotoxicity and DNA interactions of some platinum(II) complexes with substituted benzimidazole ligandsen_US
dc.typeArticle

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