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Öğe Comparison of epidural ropivacaine 0.2% and ropivacaine 0.2% in combination with sufentanil 0.75 microg mL-1 for postcaesarean analgesia.(2008) Kaya T.; Büyükkoçak U.; Başar H.; Sağsöz N.Analgesic techniques after c-section must be effective producing early mobilisation to enable mothers to care effort their babies. In this study, the comparison of ropivacaine 0.2% alone, with ropivacaine 0.2%+sufentanil 0.75 microg mL-1 for patient controlled epidural analgesia (PCEA) was aimed. Fifty women (ASA-I) were enrolled in the study. All patients had combined spinal-epidural anaesthesia. Infusion of analgesic solutions was started when sensory level decreased by two dermatome levels. The patients randomly assigned, into two groups (n=25). In Group-I, ropivacaine 0.2% and sufentanil 0.75 microg mL-1, in Group-II, ropivacaine 0.2% alone were applied (bolus 1.25 mL, lockout 30 min, with 2.5 mL h-1 background infusion). Pain (Visual Analog Scale), motor blockage (Bromage scale) and sedation (Four point scale) were evaluated during 24 hours after Caesarean, using the scales of visual analogue, bromage, and four-point, respectively. Haemodynamic and respiratory parameters, side effects, total drug consumption and additional analgesic need, were recorded. Statistical analysis included student-t, chi-square, and Mann Whitney U tests. There was no difference in demographic data, sedation scores, haemodynamic and respiratory parameters, between the groups. Motor block and pain scores were significantly higher in Group-II than in Group-I at 2 and 4. h. Total drug consumption was 65.24+/-4.20 mL for Group-I and 81.1+/-6.44 mL for Group-II, (P<0.05). Four patients in Group-I and 21 patients in Group-II received additional analgesic. Pruritus was observed more frequently in Group-I. The addition of sufentanil 0.75 microg mL-1 to ropivacaine 0.2% for PCEA after Caesarean led to more effective analgesia and less motor weakness when compared to ropivacaine 0.2% alone, especially during early postoperative period.Öğe Comparison of Serum Ykl-40 and Ischemia Modified Albulmin Levels Between Pregnant Women with Hyperemesis Gravidarum and Normal Pregnant Women(NLM (Medline), 2019) Bulanık M.; Sağsöz N.; Sayan C.D.; Yeral M.İ.; Kısa Ü.Introduction: The etiopathogenesis of HG is still unclear. Aim: The aim of this study was to investigate the levels of YKL-40 protein as an inflammatory marker and evaluate the levels of IMA as an oxidative marker in hyperemesis gravidarum women. Materials and Methods: Totally 35 patients with hyperemesis gravidarum and 35 healthy pregnants were included in the study. Singleton pregnancies between 6+0 week and 13+6 weeks of gestation, with normal fetal anatomy were included in the study. Complete blood count, complete urine analyze, biochemical tests and thyroid function tests were done. Results: There was no significant difference between groups for demographical features (age, gravidity, gestational age, body mass index). Also, there was no statistically significant difference between groups for IMA levels (p>0.05). The median level of YKL-40 was higher in pregnants with hyperemesis gravidarum than normal pregnants but the difference was not statistically significance (p>0.05). Conclusion: Further comprehensive studies with more number of patients are needed to show the efficacy of YKL-40 and IMA levels for predicting hyperemesis gravidarum and even monitoring of the treatment.Öğe The comparison of the analgesic effect of dexketoprofen trometamol with lornoxicam and placebo on post-cesarean delivery pain(2012) Aykaç E.; Büyükkoçak Ü.; Köse E.A.; Sağsöz N.Objective: The aim was to compare the effect of dexketoprofen trometamol with lornoxicam and placebo on post-cesarean delivery pain. Method: Ninety patients scheduled for cesarean-section under spinal anesthesia were randomized equally into three groups. Before the surgical incision closure, 50 mg dexketoprofen trometamol (Group D), 8 mg lornoxicam (Group L) or 0.9% NaCl (Group P) was given intravenously. After the surgery all patients received intravenous tramadol via patient controlled analgesia device (bolus dose: 20 mg, lock out: 10 min.). Postoperative pain was assessed by visual analog scale (VAS). Additional analgesic doses of tramadol (20 mg, i.v) were given when the VAS value was ? 3. The time of the first analgesic requirement, VAS values at the 1, 3, 6, 12, 24 hours of the postoperative period, additional analgesic doses of tramadol, cumulative tramadol consumption, patient satisfaction, adverse effects of drugs were recorded. Results: The time of the first analgesic requirement was significantly longer and the VAS values at the postoperative first hour was significantly lower in the Group D than the Group L (p=0.01, p=0.007; respectively). The cumulative tramadol consumption and patient satisfaction was similar between the Group D and Group L. The additional analgesic consumption at postoperative first hour was significantly lower in the Group D when compared to Group L and Group P (p=0.01, p<0.001; respectively). The total additional analgesic consumption at the end of the postoperative 24 hours was lower in the Group D when compared to Group P and Group L (p=0.01, p<0.001; respectively). Conclusion: Dexketoprofen trometamol had more analgesic efficacy for postoperative pain at early postoperative period with prolonged first analgesic requirement time, decreased additional analgesic requirement, decreased VAS values in the first postoperative hour, when compared with lornoxicam.Öğe Comparison of uterine artery Doppler sonography, saline infusion sonography and endometrial biopsy in premenopausal patients with abnormal uterine bleeding who were found to have endometrial polyps(2010) Koç H.; Noyan V.; Yücel A.; Sağsöz N.Objective: The aim of this study was to compare uterine artery doppler sonography, saline infusion sonography and endometrial biopsy results in premenopausal patients with abnormal uterine bleeding. Material and Methods: This study was performed on 60 premenopausal patients who had abnormal uterine bleeding and whose endometrial thickness were ? 5 mm. Transvaginal ultrasonography, uterine artery Doppler sonography and saline hydrosonography were performed for each patient. Afterwards, endometrial biopsies were performed and sent to the pathology department. After the pathology results were delivered, 25 patients were included in the endometrial polyp group. Patients with abnormal uterine bleeding, who didn't have any intracavitary lesions were considered as the control group. The result for transvaginal ultrasonography, uterine artery doppler sonography and saline hydrosonography were compared with pathology results. Results: The mean uterine artery resistance index value in the endometrial polyp group was 0.63 ± 0.2 and in the control group it was 0.66 ± 0.17 (p= 0.48). The mean uterine artery pulsatility index in the endometrial polyp group was 1.75 ± 0.74 and in the control group it was 1.95 ± 0.63 (p= 0.31). The sensitivity, specificity, positive predictive value and negative predictive value of saline hydrosonography in directly visualizing endometrial polyps were 96%, 84.6%, 95.7% and 85.7%, respectively (p< 0.05). Conclusion: Uterine artery doppler sonography dose not have any additive value to conventional ultrasonography and salin hydrosonography, in differentiating endometrial polyps from patients with abnormal uterine bleeding who do not have any intracavitary lesions. Copyright © 2010 by Türkiye Klinikleri.Öğe Plasma apelin levels in patients with polycystic ovary syndrome(2012) Gören K.; Sağsöz N.; Noyan V.; Yücel A.; Çağlayan O.; Bostanci M.S.Objective: The aim of the study was to evaluate plasma apelin levels in patients with polycystic ovary syndrome (PCOS) and healthy controls. Material and Methods: Plasma apelin levels, serum lipid levels, serum hormone levels, and homeostasis model assessment-insulin resistance (HOMA-IR) values of 32 patients with PCOS and 31 healthy women forming the control group were checked. Results: Plasma apelin levels of the PCOS group (0.350±0.083 ng/ml) were significantly higher than those of the control group (0.246±0.045 ng/ml) (p<0.001). No significant correlation was detected between apelin levels and biochemical or clinical data in PCOS group. Conclusion: Plasma apelin levels were significantly higher in PCOS patients. © Copyright 2012 by the Turkish-German Gynecological Education and Research Foundation.Öğe Total and lipid bound sialic acid levels in patients with polycystic ovary syndrome(AVES, 2012) Özcan A.; Yücel A.; Noyan V.; Sağsöz N.; Çağlayan O.Objective: To evaluate serum total and lipid bound sialic acid (TSA&LBSA) levels in patients with polycystic ovary syndrome (PCOS). Material and Methods: Forty women with PCOS and 35 healthy controls were enrolled in the study. Serum TSA, LBSA, follicle stimulating hormone, lutenizing hormone, estradiol, thyroid stimulating hormone, prolactin, dehydroepiandrosterone sulphate, androstenedione, free testosterone, total testosterone, 17-OH progesterone, sex hormone binding globulin, cortisol, total cholesterol, triglyceride, high density lipoprotein and low density lipoprotein were measured in each subject. Insulin resistance was estimated by fasting insulin level, fasting glucose: insulin ratio and 75-g glucose tolerance test for 2 hours. Results: Serum TSA levels were not significantly different between the groups. Serum LBSA levels were higher in patients with PCOS compared to the control group. TSA was correlated with androstenedione and HOMA-IR in the PCOS group. Positive correlations were found between LBSA and dehydroepiandrosterone sulphate in patients with PCOS. After correction for BMI, the only existing significant correlation was between LBSA and follicle stimulating hormone. Conclusion: Serum LBSA levels, which has previously been found to be higher in cardiovascular diseases and diabetes mellitus, are elevated in PCOS. © 2012 by the Turkish-German Gynecological Education and Research Foundation.
