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    Gastroesophageal reflux in children with asthma and the effect of antireflux treatment on asthma
    (Bilimsel Tip Yayinevi, 2009) Soyer, Tutku; Soyer, Ozge Uysal; Cakmak, Murat
    Although, the relationship between asthma and gastroesophageal reflux has been known for years, diagnosis and treatment of asthma triggered gastroesophageal reflux is still controversial. The studies that aimed to evaluate the relation of asthma and reflux and results of antireflux treatment are insufficient to explain the topic. The aim of this review is to present the results of studies about asthma, reflux and efficacy of antireflux treatment.
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    Pepsin levels and oxidative stress markers in exhaled breath condensate of patients with gastroesophageal reflux disease
    (W B Saunders Co-Elsevier Inc, 2013) Soyer, Tutku; Soyer, Ozge Uysal; Birben, Esra; Kisa, Ucler; Kalayci, Omer; Cakmak, Murat
    Aim: To evaluate the pepsin and oxidative stress markers in exhaled breath condensate (EBC) in patients with gastroesophageal reflux disease (GERD). Patients and Method: Patients with a presumptive diagnosis of GERD with recurrent respiratory and gastrointestinal problems aged between 2 and 14 years were included in the study. All patients underwent pH monitoring. Patients with a reflux index (RI) >= 4 were assessed as the reflux group, and those with an RO <4 were assessed as the non-reflux group. Pepsin levels and oxidative stress markers [NO metabolites (NOX) and total sulphydrile (TSH) levels] were measured in the EBC. Results: There were 24 patients in the reflux group [RI 17.6 (6.6-46.4)] [median, interquartile range] and 23 in the non-reflux group [RI 0.8 (0.5-1.9) (p < 0.001). Pepsin levels in the EBC were below the level of detection. The median levels of NOx in the EBC of children with reflux [13.7 mu mol/L (7.3-24.5)] were lower in than non-reflux group [21.0 mu mol/L (14.0-25.2)] (p = 0.034). There was a negative correlation between reflux index and NOX levels in EBC (rs: -0.331, p = 0.023). In contrast, there was no difference in TSH levels between the reflux and non-reflux groups [37.4 mu mol/L (30.2-44.6) vs 40.1 mu mol/L (37.4-44.9), respectively, (p > 0.05)]. Conclusion: Decreased levels of NOX in patients with GER disease suggest increased oxidative stress in airways of these patients. (C) 2013 Elsevier Inc. All rights reserved.