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Öğe Cranial Magnetic Resonance Imaging Findings of Bonzai Abuse: A Case Report(2016) Burulday, Veysel; Koç, Ural; Tan, Sinan; İnal, Mikail; Alpua, MuratSentetik kannabinoidler (SK) Avrupa da Spice, ABD de K2, diğer taraftan Türkiye de Bonzai ismiyle popülerleş- mişlerdir. Çağımızın tehlikesi Bonzai, komplikasyonları ve nöroradyolojik bulguları literatürde çok bilinmeyen, son zamanlarda Türkiye de popüler olan bir bitkisel kaynaklı sentetik kannabinoid ilaçtır. Bunun sonucu olarak Bon- zai veya Bonzai ilişkili komplikasyonlar konusunda rad- yoloğun nöroradyolojik olarak farkında olması önemlidir. Biz bu olgu sunumunda, bilgisayarlı tomografide iskemi ile ilişkili olabilecek hipodens alanları olan, diğer taraf- tan magnetik rezonans görüntülemesinde T2 ağırlıklı ve FLAIR sekanslarda vazojenik ödemle uyumlu olduğu dü- şünülen Bonzai suistimali olgusunun kranial görüntüleme bulgularını sunduk. Ek olarak FLAIR görüntülemede kor- pus kallozumda sinyal artışı ve kanama odakları izlendi.Öğe Diagnostic value of strain elastography for differentiation between renal cell carcinoma and transitional cell carcinoma of kidney(Springer, 2016) Inci, Mehmet Fatih; Kalayci, Tugce Ozlem; Tan, Sinan; Karasu, Sebnem; Albayrak, Eda; Cakir, Volkan; Ozkan, FuatThe objective of our study was to prospectively evaluate the diagnostic performance of strain elastography for differentiation between renal cell carcinomas (RCCs) and transitional cell carcinomas (TCCs) of kidney. A total of 99 consecutive patients who were referred to our hospital because of a newly diagnosed solid renal mass suspicious for malignancy on radiological screenings were evaluated with sonography, including strain elastography. Strain elastography was used to compare the stiffness of the renal masses and renal cortex. The ratio of strain in a renal mass and nearby renal cortex was defined as the strain index value. Mean strain index values for RCCs and TCCs were compared, and mean strain index values between histological subtypes of RCC were also compared. Although TCCs were smaller than RCCs (p < 0.001), there were no significant differences in gender distribution and mean age of the patients, and mean probe-tumor distance between RCC and TCC. The mean strain index value +/- SD for TCC (5.18 +/- 1.12) was significantly higher than the value for RCC (4.04 +/- 0.72; p < 0.001). Mean strain index value for papillary cell carcinomas (4.09 +/- 0.45) was slightly higher than that for clear cell carcinomas (3.85 +/- 0.78): however, the difference was not statistically significant (p = 0.51). Strain elastography can be used as a valuable imaging technique for preoperative differentiation between RCC and TCC of kidney.Öğe Differentiation of benign and malignant superficial soft tissue lesions using real-time strain elastography(Tubitak Scientific & Technological Research Council Turkey, 2021) Annac, Gokce; Canyigit, Murat; Tan, Sinan; Aksam, Ersin; Sungu, Nuran; Arslan, HalilBackground/aim: To evaluate benign and malignant cutaneous-subcutaneous lesions using real-time strain elastography (RTSE) and to compare the findings with histopathologic results. Materials and methods: Over a period of 10 months, 72 patients (38 with benign and 34 with malignant cutaneous and subcutaneous lesions) were prospectively included in this study. Elasticity patterns and strain ratios were examined for each lesion. Lesions were evaluated in 4 groups as yellow-red (soft; pattern-1), green-yellow (moderate; pattern-2), blue-green (hard; pattern-3) and blue (hardest; pattern-4). The stiffness of the lesions was displayed with strain ratios by comparing of a nearby reference tissue. The recorded images were compared with histopathologic findings. Results: On sonoelastograms, considering patterns 1-2 as benign and patterns 3-4 as malignant, the sensitivity, specificity, and positive and negative predictive values for the differentiation of malignant from benign lesions were 100%, 68.5%, 74%, and 100%, respectively. Considering a cut-off value of the strain ratio as > 3.05, the sensitivity, specificity, and positive and negative predictive values were 91%, 89%, 88%, and 92%, respectively. The area under the curve (AUC: 0.972) showed the excellent ability of strain elastography to differentiate benign and malignant lesions. Conclusion: RTSE is an important imaging tool to differentiate benign and malignant superficial soft tissue lesions. Our results suggest that RTSE can be used to predict malignancy since malignant lesions are more confidentially diagnosed than benign superficial soft tissue lesions on elastograms.Öğe Evaluation Of Optic Nerve With Strain And Shear Wave Elastography In Patients With Behcet's Disease And Healthy Subjects(Elsevier Science Inc, 2017) Inal, Mikail; Tan, Sinan; Demirkan, Serkan; Burulday, Veysel; Gunduz, Ozgur; Ornek, KemalThe objective of this study was to investigate the elasticity characteristics of the optic nerve using strain and shear wave elastography in patients with Behc, et's disease and to compare the results with those of healthy volunteers. Forty-six optic nerves from patients with Behc, et's disease and 54 optic nerves from healthy volunteers were investigated prospectively in this study using strain and shear wave elastography. There was a statistically significant difference in terms of elasticity patterns between patients and healthy volunteers (p < 0.001). Elastographic images of healthy volunteers revealed most optic nerves to be type 3 (51.8%); however, type 2 (40.7%) and type 1 (7.5%) were also observed. Elastographic examination of Behc, et's disease patients revealed type 2 in 52.2%, type 1 in 43.5% and type 3 in 4.3% of patients. Statistically significant differences were observed between patients and healthy volunteers in the analysis of shear wave elastography values (p < 0.001). Receiver operating characteristic curve analysis was perfect (0.933) (95% CI = 0.885-0.980), and a cutoff value of 16.5 kPa shear had very high sensitivity and specificity for the patient group. Strain and shear wave elastography findings for the optic nerves of patients with Behc, et's disease were significantly different from those for healthy volunteers. (E-mail: inal_m@hotmail.com) (C) 2017 World Federation for Ultrasound in Medicine & Biology.Öğe Evaluation of the optic nerve using strain and shear wave elastography in patients with multiple sclerosis and healthy subjects(Soc Romana Ultrasonografe Medicina Biologie-Srumb, 2017) Inal, Mikail; Tan, Sinan; Yumusak, M. Erhan; Sahan, Mehmet Hamdi; Alpua, Murat; Ornek, KemalAims: Our aim was to evaluate the elasticity features of the optic nerve using strain (SE) and shear wave elastography (SWE) in multiple sclerosis (MS) patients in comparison with healthy subjects. Material and methods: One hundred and seven optic nerves from 54 MS patients and 118 optic nerves from 59 healthy subjects were examined prospectively by SE and SWE. Optic nerves were divided into three types in accordance to the elasticity designs, as follows: type 1 predominantly blue (hardest tissue); type 2 predominantly blue/green (hard tissue); and type 3 predominantly green (intermediate tissue). Quantitative measurements of optic nerve hardness with SWE were analyzed in kilopascals. Results: Elastographic images from healthy volunteers showed mostly type 3 optic nerves (61.9%); type 2 was also found (38.1%), but type 1 was not observed. Elastographic examination of MS patients showed mostly type 2 optic nerves (88%), while some type 1 (4.6%) and type 3 optic nerves (6.5%) were rarely observed. There was a statistically significant difference in terms of elasticity patterns between patients and healthy volunteers (p<0.001). Statistically significant differences were observed between patients and healthy volunteers in the analysis of SWE values (10.381 +/- 3.48 kPa and 33.87 +/- 11.64 p< 0.001). The receiver operating characteristic curve analysis was perfect (0.993; 95% confidence interval [CI]=0.971-0.999), and a cut-off value of 18.3 kPa shear had very high sensitivity and specificity for the patient group. No significant differences were observed between patients with and without previous optic neuritis. Conclusion: SE and SWE examination findings concerning the optic nerve in MS patients demonstrated remarkable differences according to the healthy group.Öğe Evaluation of thiol-disulphide homeostasis in radiation workers(Taylor & Francis Ltd, 2017) Koc, Ural; Tan, Sinan; Ertem, Ahmet Goktug; Gumus, Mehmet; Ozbek, Betul; Erel, OzcanPurpose: To evaluate thiol-disulphide homeostasis - a novel, easily calculated, readily available, and relatively cheap oxidative stress marker - in radiation workers and compare the results with healthy controls.Materials and methods: A total of 108 participants were enrolled in the study including 63 hospital workers occupationally exposed to ionizing radiation in the units of interventional radiology, interventional cardiology and nuclear medicine. A control group consisted of 45 individuals staff in the same hospital. Serum thiol-disulphide homeostasis measurement was investigated via the spectrophotometric method newly described by Erel and Neeliolu.Results: The mean serum native thiol levels of radiation workers (528.9686.42mol/l) was significantly lower than control subjects (561.05 +/- 104.83mol/l) (p=.045). The mean serum total thiol levels of radiation workers (547.70 +/- 91.50mol/l) was lower than control subjects (580.36 +/- 112.24mol/l). Nevertheless, there was no significant difference between total thiol of exposed workers and controls.Conclusions: The results show that long-term low dose ionizing radiation may lead to oxidative stress and have side-effects in antioxidant thiol groups. We may suggest supporting radiation workers by safe antioxidant nutritional formulations and following up via both physical dosimetry and biodosimetric methods.Öğe Intracranial Lesions in Children and Adolescents with Morbid Obesity(Galenos Yayincilik, 2017) Ergur, Ayca Torel; Gunes, Sevinc Odabasi; Tan, Sinan; Tandircioglu, U. AyseBackground: Intracranial lesions may affect the hypothalamo-hypophyseal axis and lead to some neuroendocrinological dysfunctions (hyperphagia, sleep disorders and hormonal dysfunctions). There is a very limited number of studies about childhood obesity and intracranial lesions. Aims: To evaluate the incidence of intracranial lesions and its role in clinical symptoms and aetiology in cases with morbid obesity who have been admitted to the paediatric endocrinology department with this complaint. Study Design: Cross-sectional study. Methods: A total of 120 cases admitted to the paediatric endocrinology department with the complaint of morbid obesity between 2002 and 2015 were included in this study. A detailed history was taken and a physical examination was performed; biochemical, hormonal parameters were evaluated. Contrast dynamic magnetic resonance imaging was performed in order to visualize cranial pathologies. Results: An intracranial lesions was detected in 16.6% of the patients and 55% of these lesions were adenoma of the hypophysis. Prolactin levels were increased in six patients but front hypophyseal hormone levels were within normal range in the rest of the patients. Growth velocity of the patients was not affected. Conclusion: In our study, the incidence of intracranial lesions in children and adolescents with morbid obesity was much higher than in the normal population. According to this data, we are of the opinion that contrast dynamic magnetic resonance imaging is helpful in children with morbid obesity for the early detection of the mass before it causes any clinical or neurological symptoms and in the prevention of future complications.Öğe Is strain elastography beneficial for isoechoic cholangiocarcinomas?(Soc Romana Ultrasonografe Medicina Biologie-Srumb, 2016) Burulday, Veysel; Koc, Ural; Tan, Sinan…
